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Samuel Bakhoum Profile picture
Samuel Bakhoum
@Samuel_Bakhoum
#Physician_Scientist @MSKCancerCenter #Chromosomal_Instability, #aneuploidy, and #cancer co-founder @VolastraTx views expressed are my own
Dec 28, 2020 • 16 tweets • 15 min read
(1/n) A brief #tweetorial highlighting the key aspects of our recent paper in #Cancer Discovery ⁦@CD_AACR⁩ on how cancers with #Chromosomal_Instability evade immune surveillance prompting #metastasis #ScienceTwitter cancerdiscovery.aacrjournals.org/content/early/… We’ve previously shown that CIN can drive #metastasis through the generation of chronic #inflammation arising from persistent activation of #cGAS #STING signaling. However it wasn’t clear how cells eschewed the immune stimulating effect of this pathway. nature.com/articles/natur…