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jesse veenvliet Profile picture
jesse veenvliet
@jvveenvliet
proud papa | group leader @teamstembryo @mpicbg | re- and deconstructing (st)embryos | #stembryogenesis | solves problems in lab & climbing hall | views mine
Apr 16 • 15 tweets • 5 min read
📢 Out in @CellStemCell! Our @teamstembryo tour de force led by @RyanSavill4 & @VillarongaAlba! @mpicbg @PoLDresden

#gastruloids with a sweet tooth form better trunk-like-structures: doi.org/10.1016/j.stem….

B2B w/ @KStapornwongkul @LabTrivedi: doi.org/10.1016/j.stem…

(1/n) Image We can guide pluripotent stem cells to self-organise into stem-cell-based embryo models (SEMs). This opens many new possibilities for both basic biological discovery and translational purposes. There’s a reason why @naturemethods proclaimed SEMs Method of the Year 2023!

(2/n) Image
Mar 5, 2020 • 12 tweets • 12 min read
We’re proud to present our #preprint, where we induce embryo-like morphogenesis in #gastruloids, resulting in the generation of trunk-like-structures (#TLS) with #somites flanking the #neuraltube @MPI_MolGen w/ @adrianobolondi . A short summary (1/12) biorxiv.org/content/10.110… #Gastruloids are a fantastic culture system, but lack proper morphogenesis, e.g. neural cells do not form a neural tube and presomitic mesoderm does not condense into somites. Can we induce proper embryo-like morphology by mechano-chemical manipulation? Yes, we can! (2/12)