Evolution/HIV/drug resistance/soft sweeps/clinical data/SFSU/inclusivity in computing. Fall 2020 at @IBED_UvA.
She/her. Videos https://t.co/hDx00vMlfv
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Apr 21, 2022 • 13 tweets • 6 min read
I am excited to share the first chapter of an online, video-based R course for biologists. It is meant for beginners and focuses on data analysis of tabular data (what fits in an excel file). @Ryan_Fergusson7 and I made the videos. (1/n)
@Ryan_Fergusson7 The first video: R Basics with Pleuni - 1 - Why R for Biology? vimeo.com/700604380
What to expect from this class. Introducing myself (Pleuni Pennings) and Ryan Fergusson. (2/n)
Nov 12, 2020 • 19 tweets • 4 min read
This week I learned about ME/CFS when I sent a 2-line email to my PhD advisor Joachim Hermisson. Me: “Hope you & your family are well. Could you send me your recent NatRevGen paper?” His reply: “Sure, paper attached. We are not well. One of my daughters is very sick.” 1/n
In a few more back and forth emails, I learned that his daughter has very severe ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). She is so sick that she is in bed in a dark room 24hours a day. She is a teenager.2/n
May 11, 2020 • 6 tweets • 3 min read
I have now heard of 4 #COVID19 outbreaks in choirs and I am worried that choirs will not be back for a long time. Here a story on @BBCNews about a choir with a link to a traveller from Wuhan mid December: bbc.com/news/health-52… (1/n)
This one in Washington State early March reported by @RichReadReports in the @latimes 45 of 60 singers tested positive for #covid19, 2 died. latimes.com/world-nation/s… 2/n
Mar 31, 2020 • 17 tweets • 5 min read
1/ Here is day 3 of your twitter #SARSCoV2 genetics / translation course ;-)
On day 1 we saw how the virus used a polyprotein that can be cleaved into proper proteins, and on day 2 we saw how the virus can make our ribosome slip and read through a stop codon.
2/ Today, we’ll see how all the open reading frames on the last third of the #SARS-CoV2 genome get translated which will create the important structural proteins such as the famous S spike and the essential E envelope, M Membrane and N Nucleoprotein.
Mar 30, 2020 • 14 tweets • 7 min read
1/ Yesterday, I wrote about how SARS-CoV2 makes our ribosome translate its first 11 proteins – today, I'll write about how it does the next 5 proteins. All this to prep for the Genetics class I am teaching at @SFSU@SFStateBIO
2/ These first 11 proteins take up a little over 13,000 nucleotides and end with a stop codon, but #SARSCoV2 has 30,000 so how does it read the other 17,000? It's first key trick to translate beyond the stop codon is to "shift frame".
Mar 29, 2020 • 13 tweets • 5 min read
I like doing science to take my mind off of the pandemic. Plus, I need to prep my genetics class for next week. And against advice from smart people, I will talk to my students about coronavirus to remind them of “normal” genetics. (thread) 1/2/ A lot of this info is from this video: @brittaspen @hhmi
h/t @vscooper and @elsanchez09
And from viralzone.expasy.org/30?outline=all…
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