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Millions of people are popping PPIs for acid reflux without realizing the damage they're causing.
These things were designed for short-term use. We're talking 4-8 weeks max.
Yet people stay on them for years.
Here's what they're actually doing to your body:
These things were designed for short-term use. We're talking 4-8 weeks max.
Yet people stay on them for years.
Here's what they're actually doing to your body:
This post will cover:
- How PPIs actually work in your body
- The nutrient deficiencies they cause (and why)
- The gut issues that follow
- Effects on your bones and kidneys
- What's actually contributing to reflux in the first place
Let's get into it.
(NOT MEDICAL ADVICE)
- How PPIs actually work in your body
- The nutrient deficiencies they cause (and why)
- The gut issues that follow
- Effects on your bones and kidneys
- What's actually contributing to reflux in the first place
Let's get into it.
(NOT MEDICAL ADVICE)
How PPIs Actually Work
PPIs are prodrugs. This means they're inactive when you swallow them.
They travel to your stomach lining and accumulate in the parietal cells. Once they hit the acidic environment inside these cells, they activate and get to work.
The activated PPI forms a covalent bond with your proton pumps. This is an irreversible bond. Those specific pumps are now out of commission.
Your stomach can only make acid again once it synthesizes brand new pumps. This takes roughly 36-72 hours.
PPIs are prodrugs. This means they're inactive when you swallow them.
They travel to your stomach lining and accumulate in the parietal cells. Once they hit the acidic environment inside these cells, they activate and get to work.
The activated PPI forms a covalent bond with your proton pumps. This is an irreversible bond. Those specific pumps are now out of commission.
Your stomach can only make acid again once it synthesizes brand new pumps. This takes roughly 36-72 hours.
THREAD ๐งต | A US power crisis is unfolding โ and almost no one is connecting the dots to #silver
1/
The US is heading toward a power crisis.
By 2028, peak electricity demand is expected to exceed available generation.
By 2033, the shortfall could reach 175 gigawatts โ a level that threatens grid stability itself.
This is not speculation. These are planning numbers.
The US is heading toward a power crisis.
By 2028, peak electricity demand is expected to exceed available generation.
By 2033, the shortfall could reach 175 gigawatts โ a level that threatens grid stability itself.
This is not speculation. These are planning numbers.
2/
Whatโs driving this surge in demand?
โก AI data centers
โก EV adoption
โก Factory reshoring
โก Electrification of everything
Electricity demand is accelerating faster than generation can be built. And reserves are shrinking.
Whatโs driving this surge in demand?
โก AI data centers
โก EV adoption
โก Factory reshoring
โก Electrification of everything
Electricity demand is accelerating faster than generation can be built. And reserves are shrinking.
1).
โA Utah man who is deaf is suing the U.S. Department of Homeland Security (@DHSgov) and several members of the @realDonaldTrump administration, saying he U.S. Immigration and Customs Enforcement agents injured him when they apprehended him at a Taylorsville bus stop.
โA Utah man who is deaf is suing the U.S. Department of Homeland Security (@DHSgov) and several members of the @realDonaldTrump administration, saying he U.S. Immigration and Customs Enforcement agents injured him when they apprehended him at a Taylorsville bus stop.
2).
In a suit filed in U.S. District Court in Utah, Arturo Ruvalcaba accused the agents of not working to communicate with him when he tried to tell them he couldnโt understand their demands.
In a suit filed in U.S. District Court in Utah, Arturo Ruvalcaba accused the agents of not working to communicate with him when he tried to tell them he couldnโt understand their demands.
3).
He said in the complaint that the agents became ยปphysically aggressiveยซ, hurt his arm and put him in handcuffs โ and only released him when they found his green card.โ
Dec. 13, 2025
๐ฟ๐๐ ๐พ๐๐๐ ๐ท๐๐๐ ๐ฟ๐๐๐๐๐๐ (@sltrib) archive.ph/xXfpq
He said in the complaint that the agents became ยปphysically aggressiveยซ, hurt his arm and put him in handcuffs โ and only released him when they found his green card.โ
Dec. 13, 2025
๐ฟ๐๐ ๐พ๐๐๐ ๐ท๐๐๐ ๐ฟ๐๐๐๐๐๐ (@sltrib) archive.ph/xXfpq
1. Watch #Dhurandhar on the big screen.I watched it today & came away thoroughly impressed at the finesse & execution of @AdityaDharFilms. With a brilliant cast where none is dispensable,a tightly written script & a scintillating background score, 214 minutes isnt long enough.
2. Highlights of the content- The candid depiction of the geopolitical challenges Bharat is faced with,the civilizational conflict at the heart of it,the fifth columnists within Bharat who aid the enemy, and the difficult terrain that patriots have to navigate to protect Bharat.
3. The cast- @ActorMadhavan, Akshaye Khanna, @bolbedibol, @RanveerOfficial, @duttsanjay, @rampalarjun are obviously the standouts. Of these,Akshaye Khanna, @RanveerOfficial & @bolbedibol are absolutely brilliant. However, Akshaye Khanna dominates every scene he is in & how!
Anthropic literally dropped the Prompt Guide to 10x your Claude Opus/Sonnet 4.5
10 best practices you should know. Bookmark this. ๐
10 best practices you should know. Bookmark this. ๐
1. Be Painfully Specific
Say exactly what you want (format, tone, length, audience). Claude 4 follows instructions literally.
Say exactly what you want (format, tone, length, audience). Claude 4 follows instructions literally.
2. Tell It Why You Want It
A one-line reason ("this is for execs / this must be legally safe / this goes into a deck") improves results fast.
A one-line reason ("this is for execs / this must be legally safe / this goes into a deck") improves results fast.
The UCP has made 2025 one of the darkest years for Albertaโs democracy.
Albertans can turn on the lights in 2026.
By simply being Albertan.
Let me explain. ๐งต
Albertans can turn on the lights in 2026.
By simply being Albertan.
Let me explain. ๐งต
Populists donโt just win by mobilizing their base โ they win by convincing everyone else that their base is bigger and more mainstream than it actually is. Thatโs the core of the populist playbook: make a small, loud group look universal so everyone else stays quiet.
Two social dynamics make this work: pluralistic ignorance (people privately disagree but think theyโre alone) and the spiral of silence (when people think theyโre alone, they stay quiet). The quieter most of us are, the more it looks like โeveryoneโ backs illiberal moves.
For context: Epsteinโs Zorro Ranch had just three bedrooms.
2/
The blueprints tell a different story. I will break it down in Part 2 of my Zorro ranch series on substack (link in bio) itโs free
The blueprints tell a different story. I will break it down in Part 2 of my Zorro ranch series on substack (link in bio) itโs free
3/
From this angle you can see the walking path/maze is an engineered flat surface and is almost roof level with the main compound.
From this angle you can see the walking path/maze is an engineered flat surface and is almost roof level with the main compound.
Nigeriaโs FIRSโFrance tax partnership: facts, context, and why it is not โslaveryโ
Breakdown:๐
In recent weeks, Nigeriaโs tax cooperation with France, anchored through the Federal Inland Revenue Service (FIRS, has attracted intense public debate with so many people...
Breakdown:๐
In recent weeks, Nigeriaโs tax cooperation with France, anchored through the Federal Inland Revenue Service (FIRS, has attracted intense public debate with so many people...
With no or little understanding about the partnerships calling it "modern slavery." One thing about Nigerians is that, a lot of people speak so much confidently on a subject they do not understand and instead of asking questions,
They assume and draw their inferences on the matter filled with own biase which drives misinformation, and put fear into people.
Kiddo analyzed several months of Swear Jar P&L and asked if I'd like to purchase swear words in advance
I'm going to stop swearing one day, and two towns over some grade schooler isn't going to be able to make his monthly Minecraft nut
This isn't a top. The top will be in when these guys (obviously Goldman alt accounts) offer me credit default swaps on my own CDO
NATO chief Mark Rutte warns Russia could wage war against the alliance "on the scale our grandparents and great-grandparents endured" โ referencing World War-level conflict. He says Russia could be ready to use military force against NATO within five years โ Reuters. 1/
In a Berlin speech, Rutte warned that too many NATO allies don't feel the urgency of Russia's threat and are "quietly complacent." He urged rapid increases in defense spending and production: "The time for action is now." 2/
"We are Russia's next target," Rutte declared. "Conflict is at our door. Russia has brought war back to Europe. And we must be prepared." He warned that allies wrongly believe time is on their side โ it's not. 3/
Andreas Halvorsen has one of the most unconventional backgrounds for a hedge fund manager.
He led a Norwegian Navy SEAL team before joining Tiger Global, then launched Viking Global in 1999.
In 2008, Viking lost just 1.9%. Today, Viking is a $50B+ fund.
Letโs dive in!
He led a Norwegian Navy SEAL team before joining Tiger Global, then launched Viking Global in 1999.
In 2008, Viking lost just 1.9%. Today, Viking is a $50B+ fund.
Letโs dive in!
Andreas grew up in Norway and graduated from the Norwegian Naval Academy where he led a SEAL team. But he wanted more so he moved to the US and got his MBA from Stanford.
In 1992, he joined Julian Robertson's Tiger Management where he became Director of Equities.
In 1992, he joined Julian Robertson's Tiger Management where he became Director of Equities.
In October 1999, he left Tiger to co-found Viking Global with fellow Tiger colleagues David Ott and Brian Olson.
They launched with $520M, right before the dot-com crash. The experience made protecting downside a core tenet of their process.
They launched with $520M, right before the dot-com crash. The experience made protecting downside a core tenet of their process.
Why were you in Tel Aviv? And when was that?
Why Tel Aviv though? Seems awfully specific and there are tons of other destinations.
Lol, were you following Jared Kushner around?
