Thread Reader helps you read and share Twitter threads easily!
I'm @ThreadReaderApp a Twitter bot here to help you read threads more easily. To trigger me, you just have to reply to (or quote) any tweet of the thread you want to unroll and mention me with the "unroll" keyword and I'll send you a link back on Twitter 😀
— Thread Reader App (@threadreaderapp) November 25, 2017
X thread is series of posts by the same author connected with a line!
From any post in the thread, mention us with a keyword "unroll"
@threadreaderapp unroll
Follow @ThreadReaderApp to mention us easily!
Practice here first or read more on our help page!
Recent
@JamesSurowiecki The Biden-Harris Administration was most certainly not “unprepared.”
Any competent professional knows that, if you release undocumented foreign nationals into the United States, you only inspire more to hire criminal human traffickers and undertake the dangerous journey.
1/
Any competent professional knows that, if you release undocumented foreign nationals into the United States, you only inspire more to hire criminal human traffickers and undertake the dangerous journey.
1/
@JamesSurowiecki @threadreaderapp please unroll
🧵 Thread: How the U.S. can legally exit IOM — step‑by‑step
🇺🇸 The U.S. joined IOM under an executive agreement, authorized by law (see 22 U.S.C. § 2601). law.cornell.edu/uscode/text/22…
🇺🇸 The U.S. joined IOM under an executive agreement, authorized by law (see 22 U.S.C. § 2601). law.cornell.edu/uscode/text/22…
📄 IOM’s governing document — the IOM Constitution — allows any member state to withdraw by giving written notice to the IOM Secretary‑General. publications.iom.int/system/files/p…
📆 Once that notice is delivered, membership ends at the close of the next financial year (per the Constitution’s exit provisions). publications.iom.int/system/files/p…
Quick Decode: OKC Thunder
1.
Before they were the Oklahoma Thunder they were the Seattle SuperSonics.
Microsoft Co-founder Paul Allen was one of only two votes against the move, this is important context for decoding the team because if we look at the move...
1.
Before they were the Oklahoma Thunder they were the Seattle SuperSonics.
Microsoft Co-founder Paul Allen was one of only two votes against the move, this is important context for decoding the team because if we look at the move...
2.
09/02/2008 Google Chrome Launch: Takes on Microsoft Internet Explorer (Billed As Fastest)
09/03/2008 Seattle SuperSonics Become Oklahoma City Thunder
FAST = Thunder
If it were only this I wouldn't have made the connection, but it's a hypothesis to test, and the first win...
09/02/2008 Google Chrome Launch: Takes on Microsoft Internet Explorer (Billed As Fastest)
09/03/2008 Seattle SuperSonics Become Oklahoma City Thunder
FAST = Thunder
If it were only this I wouldn't have made the connection, but it's a hypothesis to test, and the first win...
3.
Until 2025 their biggest wins were 2012
05/21/2012 Google Chrome Overtakes Internet Explorer as World's Top Browser
05/21/2012 OKC Thunder Wins Conference Semifinals Against Lakers
06/06/2012 Google/Facebook/Yahoo World IPv6 Launch
06/06/2012 OKC Thunder Wins Conference Title
Until 2025 their biggest wins were 2012
05/21/2012 Google Chrome Overtakes Internet Explorer as World's Top Browser
05/21/2012 OKC Thunder Wins Conference Semifinals Against Lakers
06/06/2012 Google/Facebook/Yahoo World IPv6 Launch
06/06/2012 OKC Thunder Wins Conference Title
Enhance your mitochondrial function and your health will improve.
After all, mitochondrial dysfunction is implicated in a host of health conditions ranging from chronic fatigue, low testosterone, depression, bipolar disorders and neurodegenerative diseases all the way to cardiovascular issues, diabetes and even sleep apnea.
Here's how to power up your cells for better health (a 5-minute read that will help move you towards the right direction)🧵
After all, mitochondrial dysfunction is implicated in a host of health conditions ranging from chronic fatigue, low testosterone, depression, bipolar disorders and neurodegenerative diseases all the way to cardiovascular issues, diabetes and even sleep apnea.
Here's how to power up your cells for better health (a 5-minute read that will help move you towards the right direction)🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*
First, what are mitochondria?
Mitochondria are subcellular organelles that likely originated from ancient α-proteobacteria engulfed by eukaryotic cells.
These organelles produce the vast majority of cellular energy through adenosine triphosphate (ATP), which is needed to power every cell's biochemical reactions.
They also modulate processes like cell signaling, calcium homeostasis and apoptosis.
So it’s really no wonder that mitochondrial dysfunction is implicated in a host of health conditions.
When it comes to the structure of these double-membrane organelles, it’s a good idea to be aware of the following.
We have the:
-Outer membrane that is highly permeable due to porins such as voltage-dependent anion channels that allow small molecules and ions to pass freely.
-Inner membrane that is less permeable, with selective transporters, that houses the electron transport chain (ETC) and ATP synthase.
-Intermembrane space that is the region between the membranes.
This one is enriched with protons during ATP synthesis, creating a gradient essential for energy production through chemiosmosis.
-Mitochondrial matrix that is the innermost compartment, containing mitochondrial DNA (mtDNA), 70S ribosomes and enzymes for metabolic pathways like the Krebs cycle.
First, what are mitochondria?
Mitochondria are subcellular organelles that likely originated from ancient α-proteobacteria engulfed by eukaryotic cells.
These organelles produce the vast majority of cellular energy through adenosine triphosphate (ATP), which is needed to power every cell's biochemical reactions.
They also modulate processes like cell signaling, calcium homeostasis and apoptosis.
So it’s really no wonder that mitochondrial dysfunction is implicated in a host of health conditions.
When it comes to the structure of these double-membrane organelles, it’s a good idea to be aware of the following.
We have the:
-Outer membrane that is highly permeable due to porins such as voltage-dependent anion channels that allow small molecules and ions to pass freely.
-Inner membrane that is less permeable, with selective transporters, that houses the electron transport chain (ETC) and ATP synthase.
-Intermembrane space that is the region between the membranes.
This one is enriched with protons during ATP synthesis, creating a gradient essential for energy production through chemiosmosis.
-Mitochondrial matrix that is the innermost compartment, containing mitochondrial DNA (mtDNA), 70S ribosomes and enzymes for metabolic pathways like the Krebs cycle.
Now let’s dive a bit deeper into their main functions.
Let's start with ATP production.
Our cells require, well, energy in order to run properly.
Mitochondria produce ATP through oxidative phosphorylation in the ETC.
How?
In a nutshell, electrons from NADH (complex I) and FADH₂ (complex II) pass through complexes III and IV, pumping protons into the intermembrane space. The resulting proton gradient drives ATP synthase to convert ADP and inorganic phosphate (Pi) into ATP.
If you have no idea what these are, ATP production happens primarily through three stages:
-Glycolysis (happens in the cytoplasm)
-The citric acid cycle (or the Krebs cycle (happens in the mitochondrial matrix))
-Oxidative phosphorylation (happens across the mitochondrial inner membrane)
Glycolysis is anaerobic (no oxygen needed) and takes one glucose molecule breaks it into two 3-carbon pyruvate molecules through a 10-step enzymatic process (glucose gets two phosphates added whcich uses 2 ATP and gives us fructose-1,6-bisphosphate which splits into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, then the former also converts to G3P, so we get two G3Ps and each one is then oxidized (loses electrons to NAD⁺ and forms 2 NADH (these basically “carry” energy)).
Finally phosphates are transferred to ADP making 4 ATP total (only 2 were used). After some shuffling, you’re left with 2 pyruvate.
Now, we take these 2 pyruvate molecules and each one is converted to acetyl-CoA by pyruvate dehydrogenase. This process releases CO₂ and generates 2 NADH.
For each acetyl-CoA, the following happens: Acetyl-CoA and oxaloacetate get together to form citrate which reshuffles into isocitrate, then isocitrate loses CO₂ and electrons, forming α-ketoglutarate and 1 NADH.
Now that the first oxidation is done, we move to the second one were α-Ketoglutarate drops another CO₂, yielding succinyl-CoA and 1 NADH.
Now in this critical step, succinyl-CoA transfers a phosphate to GDP (making GTP, which converts to 1 ATP).
The oxidations don’t stop here and succinate becomes fumarate (1 FADH₂), then malate, then oxaloacetate (1 NADH), completing the loop.
Let's start with ATP production.
Our cells require, well, energy in order to run properly.
Mitochondria produce ATP through oxidative phosphorylation in the ETC.
How?
In a nutshell, electrons from NADH (complex I) and FADH₂ (complex II) pass through complexes III and IV, pumping protons into the intermembrane space. The resulting proton gradient drives ATP synthase to convert ADP and inorganic phosphate (Pi) into ATP.
If you have no idea what these are, ATP production happens primarily through three stages:
-Glycolysis (happens in the cytoplasm)
-The citric acid cycle (or the Krebs cycle (happens in the mitochondrial matrix))
-Oxidative phosphorylation (happens across the mitochondrial inner membrane)
Glycolysis is anaerobic (no oxygen needed) and takes one glucose molecule breaks it into two 3-carbon pyruvate molecules through a 10-step enzymatic process (glucose gets two phosphates added whcich uses 2 ATP and gives us fructose-1,6-bisphosphate which splits into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, then the former also converts to G3P, so we get two G3Ps and each one is then oxidized (loses electrons to NAD⁺ and forms 2 NADH (these basically “carry” energy)).
Finally phosphates are transferred to ADP making 4 ATP total (only 2 were used). After some shuffling, you’re left with 2 pyruvate.
Now, we take these 2 pyruvate molecules and each one is converted to acetyl-CoA by pyruvate dehydrogenase. This process releases CO₂ and generates 2 NADH.
For each acetyl-CoA, the following happens: Acetyl-CoA and oxaloacetate get together to form citrate which reshuffles into isocitrate, then isocitrate loses CO₂ and electrons, forming α-ketoglutarate and 1 NADH.
Now that the first oxidation is done, we move to the second one were α-Ketoglutarate drops another CO₂, yielding succinyl-CoA and 1 NADH.
Now in this critical step, succinyl-CoA transfers a phosphate to GDP (making GTP, which converts to 1 ATP).
The oxidations don’t stop here and succinate becomes fumarate (1 FADH₂), then malate, then oxaloacetate (1 NADH), completing the loop.
I didn’t expect AI to beat my own moving-average knowledge.
But then I tested Grok3’s EMA slope idea…
And the results were honestly insane.
The base strategy came from my Breakout Trading Formula.
It worked, but it wasn’t good enough for Nasdaq.
AI suggested a slope filter using EMA(25) and its value 25 bars ago.
On the main timeframe it looked weak.
So I switched to daily data, instantly better.
Then I ran every scenario:
> Positive slope
> Negative slope
> Rest mode
Positive slope barely helped.
Negative slope made things worse.
Rest mode showed signs of life.
But the daily filter removed too many trades.
So I dropped from daily - 240-min.
Still needed tuning.
Then I expanded the slope range.
And suddenly the whole strategy came to life:
Slope between –15 and +15 delivered:
> $59,000 net profit
> $4–5k drawdown
> 12:1 profit/drawdown ratio
> $255 average trade
Neighbor values like 10 and 20 also worked - a sign of robustness.
AI gave the seed… but trading experience finished the job.
Watch the video and get the free resource in the comments.
But then I tested Grok3’s EMA slope idea…
And the results were honestly insane.
The base strategy came from my Breakout Trading Formula.
It worked, but it wasn’t good enough for Nasdaq.
AI suggested a slope filter using EMA(25) and its value 25 bars ago.
On the main timeframe it looked weak.
So I switched to daily data, instantly better.
Then I ran every scenario:
> Positive slope
> Negative slope
> Rest mode
Positive slope barely helped.
Negative slope made things worse.
Rest mode showed signs of life.
But the daily filter removed too many trades.
So I dropped from daily - 240-min.
Still needed tuning.
Then I expanded the slope range.
And suddenly the whole strategy came to life:
Slope between –15 and +15 delivered:
> $59,000 net profit
> $4–5k drawdown
> 12:1 profit/drawdown ratio
> $255 average trade
Neighbor values like 10 and 20 also worked - a sign of robustness.
AI gave the seed… but trading experience finished the job.
Watch the video and get the free resource in the comments.
Full demo of how I turned the slope filter into a real Nasdaq weapon.
It is almost impossible to get even Google’s gemini to be able to write an Onegin stanza that conforms to the rules of the form & expresses anything coherent at all. Try it yourself— it required for me 20 passes with me flagging every single failure & explaining the nature of the failure. In the end it was still a dogshit poem.
I think this proves that Alexander Pushkin was more of a genius polymath than the greatest chess player of all time. Chess was easier to solve. Writing Eugene Onegin is a miracle.
The thing with an Onegin stanza is that it is far more technical than any other sonnet, as it requires a specific quatrain to quatrain alteration of the variance of masculine & feminine end rhymes— & feminine end rhymes in English are determined by the cadence of speech & so cannot be determined by any abstract rule other than “reading it aloud in time”
For those confused... today is a "Holy Shit we need US Dollars" Day. Nothing more complicated than that....
Bonds down, Stocks Down, Gold/silver/BTC flat/down. Commodities down.
It's a mild deflation day as we begin another leg of the unwind of the Yen Carry Trade.
The EU has begun selling their stock of USTs... you can see it in the internal US Yield Spreads. (see chart).
/1
Bonds down, Stocks Down, Gold/silver/BTC flat/down. Commodities down.
It's a mild deflation day as we begin another leg of the unwind of the Yen Carry Trade.
The EU has begun selling their stock of USTs... you can see it in the internal US Yield Spreads. (see chart).
/1
Over the past 3+ years, it's been different vibe... whenever there was a sell off of the long-end of the YC you would see a simultaneous move into 1/2/3 yrs.
Now you aren't seeing it. The YC inversion in the belly of the curve is going away. I've argued that this was a manipulated situation based on massive EU/BoE buying and selling. Previously, when Yellen was Treas. Sec. you saw the same thing but with her biasing issuance to sell the same story.
Now the "US Recession" story is ending. We were in a recession... now we're beginning to come out of it. And the need for USDs overseas is beginning to overwhelm markets.
Note this same Yield spread series from April-May 2025.
/2
Now you aren't seeing it. The YC inversion in the belly of the curve is going away. I've argued that this was a manipulated situation based on massive EU/BoE buying and selling. Previously, when Yellen was Treas. Sec. you saw the same thing but with her biasing issuance to sell the same story.
Now the "US Recession" story is ending. We were in a recession... now we're beginning to come out of it. And the need for USDs overseas is beginning to overwhelm markets.
Note this same Yield spread series from April-May 2025.
/2
When you factor that into what's happening in the JGB market -- big long-end sell off -- you get more of the picture.
The Yen Carry Trade is going away.
But it's putting upward pressure on the EUR/JPY while the ECB and BoE have both cut all year far more than the Fed.
They gorged themselves on USTs during the high interest rate years and are now beginning the sell cycle as rates come down.
Let's see who buys these. Nothing is interesting in the UST 10 and 30 year markets until we get to 4.25% and 5%
But for Germany trading now > 2.8% which Lagarde has defended for more than 3 years(!) what is she going to do? She can't cut. And She can't raise.
Neither can Bailey at the BoE. Nor Carney at the BoC.
The SNB is already back to the zero-bound, turning the CHF into the carry currency. Does Swittzerland have the same capacity to liquefy European markets as Japan did?
Don't let the Japan bears sell you a pig in a poke. Japan is normalizing... and the one is most exposed to this is Europe, not the US.
The Yen Carry Trade is going away.
But it's putting upward pressure on the EUR/JPY while the ECB and BoE have both cut all year far more than the Fed.
They gorged themselves on USTs during the high interest rate years and are now beginning the sell cycle as rates come down.
Let's see who buys these. Nothing is interesting in the UST 10 and 30 year markets until we get to 4.25% and 5%
But for Germany trading now > 2.8% which Lagarde has defended for more than 3 years(!) what is she going to do? She can't cut. And She can't raise.
Neither can Bailey at the BoE. Nor Carney at the BoC.
The SNB is already back to the zero-bound, turning the CHF into the carry currency. Does Swittzerland have the same capacity to liquefy European markets as Japan did?
Don't let the Japan bears sell you a pig in a poke. Japan is normalizing... and the one is most exposed to this is Europe, not the US.
On Thu 11 December, @AuditorGenAB releases 8 reports, incl:
• annual audit GoA books
• performance audit: access to post-secondary ed
• performance audit: AHS public performance reporting
• travel, meal & hospitality expenses
• mine financial security program assessment
🍿
• annual audit GoA books
• performance audit: access to post-secondary ed
• performance audit: AHS public performance reporting
• travel, meal & hospitality expenses
• mine financial security program assessment
🍿
@AuditorGenAB @TheBreakdownAB @cspotweet @RobBreakenridge @Lorian_H @reportrix @LukaszukAB @alanna_smithh @ByMatthewBlack @PfParks @JMeddings Aside from folks I tagged, I wonder if @politicalham @MBellefontaine @BradenMannsYYC @maxfawcett @jennAA2014 @kasza_leslie @FionaMattatall @UbakaOgbogu @AndieWinnipeg @andrew_leach would be interested in those audit reports.
I have huge deadline Sun 14 Dec, but will have a peek.
I have huge deadline Sun 14 Dec, but will have a peek.
@threadreaderapp unroll please
ETFs made my wife and I millionaires in 7 years.
But there's 8,754 to choose from.
Here are 10 ETFs that can make you a millionaire in 2026:
But there's 8,754 to choose from.
Here are 10 ETFs that can make you a millionaire in 2026:
1. Total US Stock Market: $VTI
Top 10 Holdings:
- NVIDIA
- Microsoft
- Apple
- Amazon
- Meta Platforms Class A
- Broadcom
- Alphabet Class A
- Alphabet Class C
- Berkshire Hathaway Class B
- Tesla
10 year annual return: 14%
Best year: 33.45%
Worst year: -36.9%
Top 10 Holdings:
- NVIDIA
- Microsoft
- Apple
- Amazon
- Meta Platforms Class A
- Broadcom
- Alphabet Class A
- Alphabet Class C
- Berkshire Hathaway Class B
- Tesla
10 year annual return: 14%
Best year: 33.45%
Worst year: -36.9%
2. Total International: $VXUS
Top 10 Holdings:
- Taiwan Semiconductor
- ASML Holding
- Nestle
- Samsung Electronics
- Novo Nordisk
- Toyota Motor
- Shell PLC
- AstraZeneca
- LVMH
- HSBC Holdings
10 year annual return: 8%
Best year: 27.46%
Worst year: -16.09%
Top 10 Holdings:
- Taiwan Semiconductor
- ASML Holding
- Nestle
- Samsung Electronics
- Novo Nordisk
- Toyota Motor
- Shell PLC
- AstraZeneca
- LVMH
- HSBC Holdings
10 year annual return: 8%
Best year: 27.46%
Worst year: -16.09%
On December 2, 2025, FAIR filed a federal civil rights complaint with the U.S. Department of Education’s Office for Civil Rights against North Thurston Public Schools (NTPS) in Lacey, Washington. The complaint alleges violations of Title VI and Title VII of the Civil Rights Act of 1964 for sponsoring racially segregated staff events, despite being informed by FAIR of the legal violations one year earlier.
In November 2024, FAIR sent a detailed letter to NTPS Superintendent Troy Oliver explaining that the district’s planned “Educators of Color” event violated federal civil rights law. Our letter cited Supreme Court precedent including Students for Fair Admissions v. Harvard and explicitly urged the district to ensure all employees could attend regardless of race.
NTPS ignored FAIR’s guidance. On November 12, 2025, the district’s Equity and Languages Department sent an email inviting only “staff of color” to a December gathering. This time, the district attempted to conceal the discriminatory nature by avoiding public flyers and relying on a restricted email list and word-of-mouth among selected employees.
@dhanyarajendran 1 Thread:
Here is the truth that i have put together so people understand facts from fiction, that a fraudulent case fought by the mighty has been defeated, that Dharma won in the end . Now Dileep will talk as he was silent for 8 yrs as case was subjudice ! Wait for that
Here is the truth that i have put together so people understand facts from fiction, that a fraudulent case fought by the mighty has been defeated, that Dharma won in the end . Now Dileep will talk as he was silent for 8 yrs as case was subjudice ! Wait for that
@dhanyarajendran 2
Truth on Actor Dileep’s fake fraudulent case:
The court has acquitted Dileep of all charges related to conspiracy and destruction of evidence in the 2017 actress assault case because the prosecution could not prove his guilt beyond reasonable doubt over an eight‑to‑nine‑year
Truth on Actor Dileep’s fake fraudulent case:
The court has acquitted Dileep of all charges related to conspiracy and destruction of evidence in the 2017 actress assault case because the prosecution could not prove his guilt beyond reasonable doubt over an eight‑to‑nine‑year
@dhanyarajendran 3
Truth on Actor Dileep’s fake fraudulent case:
trial. However, several other accused, including Pulsar Suni, have been convicted of abduction, sexual assault and related offences, and will be sentenced separately.
What the court actually decided
A Kerala sessions court in
Truth on Actor Dileep’s fake fraudulent case:
trial. However, several other accused, including Pulsar Suni, have been convicted of abduction, sexual assault and related offences, and will be sentenced separately.
What the court actually decided
A Kerala sessions court in
ALERT: Former FBI agents file suit alleging "unlawful retaliation" against Kash Patel & FBI.. for firings over their kneeling response during DC unrest after George Floyd murder
Suit: "As a result of their tactical decision to kneel, the mass of people moved on without escalating to violence"
Suit: "As a result of their tactical decision to kneel, the mass of people moved on without escalating to violence"
The dozen fired FBI agents are seeking a court order to restore their jobs and provide backpay
Suit: "Plaintiffs were among the FBI personnel deployed during this period and saw the potential for violence first-hand" .. they say the kneeling was a de-escalation tool
Suit: "Plaintiffs were among the FBI personnel deployed during this period and saw the potential for violence first-hand" .. they say the kneeling was a de-escalation tool
FBI agents lawsuit (MORE): "Plaintiffs had been informed that the purpose of the deployment was to show a visible law enforcement presence, and they wore vests marked 'FBI' and carried their firearms. But they were not properly prepared or instructed to conduct crowd control operations"
