Article says 97% of new drugs tested for cancers never make it to market 👉 IMO key to better #cancer therapies will require widespread recognition of the tumor #microbiome/virome...+ the fact that pathogens in such communities can drive changes in #tumor gene expression
Good example of the trend 👉 “Our study demonstrates that #pancreatic adenocarcinoma (PDAC) #microbiome composition, which cross-talks to the gut microbiome, influences the host immune response and natural history of the disease.” cell.com/cell/fulltext/…
Or 👉 “...these data indicate that microbial DNA is present in the #breast and that #bacteria or their components may influence the local immune microenvironment. Our findings suggest a previously unrecognized link between dysbiosis and breast cancer”: journals.plos.org/plosone/articl…
Or 👉 “Overall, our data support a model in which the #bacteriophage community modulates the bacterial community and, through those interactions, indirectly influences the bacteria driving colorectal cancer progression”: mbio.asm.org/content/9/6/e0…
Or👉 “These data suggest that endogenous #microbiota promote the crippling immune-suppression characteristic of [pancreatic ductal adenocarcinoma (PDA)] and that the microbiome has potential as a therapeutic target in the modulation of disease progression”:cancerdiscovery.aacrjournals.org/content/early/…
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