Very proud: @Christoefur11 got his first (and well-deserved!) first-author paper published today! Yes, we are still doing some #HCV research! Found four host genes determining #virus replication efficiency in #Huh7 cells!
Read more below… 1/4
mdpi.com/1999-4915/12/1…
2/4:
In a nutshell: THAP7 can increase replication (#replicon & #infection) more than 10x in low passage Huh7! Fine balance between NR0B2 (= SHP) and FXR important for optimal #bileacid and #cholesterol #metabolism: HCV down by 2 log when too much NR0B2 around!
3/4:
Fun fact: this paper is an important piece of @Christoefur11’s PhD thesis, but it also (finally!!) concludes the PhD thesis of his PI @MarcoBinderHD 😅! On the hunt for HCV host factors 2003-2007 in Volker Lohmann's lab– basic data for current paper were done back then!
4/4:
And very impressed with @VirusesMDPI – super friendly editorial staff, blazing turnaround times! Handed in revised manuscript Dec 18, accepted & proofs Dec 28, published Dec 29! „Open reviews“ policy– read reviewers reports! German Society for Virology (GfV) partner journal!
OMG, @Friedemann1, just realized we forgot to acknowledge
you for the beautiful Rift reporter! Shame on me 🥺… this was the last experiment we added for the revision and I simply forgot to update the acknowledgements :( So now at last: THANK YOU!!
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