Thread by @YDrshivaji

W Maharashtra
#covid19 has reached hinterland in tier 2 /3 cities & beyond becoming uncontrollable as all beds in different designated centers are occupied full with covid19 person
Admitted either due to breathlessness requiring oxygen or comorbidities abound requiring vigilance

Pandemic Decipher
1/25
covid19 is an attack on our distorted might In our #Variedresponse most will overcome, some would suffer protracted misery & sadly unlucky few, FEW won't survive

We must empathize, urgently mitigate & strive best to protect humanity as we face this menace

2
Pertinently this virus is a #Stresstest to physiological, psychological & immunological competency, challenging each individual until present time
Testing our multisystemic resilience, developmental journey, comorbidities, immune memory & subjecting us to scrutiny of viability

3
#Comorbidities are myriad inflictions that one carries or develops & affects ones competency to any insult outside our comfort zone, those inflictons burden our survival mechanisms as we fight to withstand, endure & cope while facing impending threat challenging life to hilt

4
Evolutionary Renin Angiotensin Aldosterone System is the prime component to HPA axis handles #Stressresponse RAAS sustains our agility to survive, regulates normal vessel tone HTN reflects chronic derangement, puzzle to peripheral vascular resistance inflicting end organ damage

5
#Paradigmshift
There's obvious indifference, massive social derangement, to any discerned mind How eager, prepared we are & intend to act counts

Skepticism derails scientific wisdom vital to potential sway each wield & collectively we must usher prevention control to survive

6
This pandemic attacks vulnerable Reality haunts to once Ambitious, Elite, Type A High Achiever but now consumed #domiciled to multiple comorbidities being burdened jeopardizing own physiology, yearning relief & now plans to amend health as clock is ticking away

7
Food abundance is an evolutionary journey from hunter gatherers until our #Spoiltchoices patronize processed food
We delegate physical tasks to prefer sedentary life comforts Our food habit patterns & vices initiate pathological derangement & cause moribund systemic changes

8
Virus binds ACE2 Receptor & cofactors @ progenitor cells Clara-club, Pneumoctye2 & endothelial cell at lungs, myriad vessels to initiate inflammatory response, hijack #RAASSCoV2Axis system on cells, down regulate on purpose to replicate & spread by droplet from one host to next

9
Evolutionary drive to succeed engenders purpose to strive more Our ambition perpetuates #Stress as we get consumed inflicting collateral damage while achieving fleeting success Our relevance is linked to eminent status, enduring goals to achieve hierarchy in race against time

10
Choices cities offer attract all, spares none, to sustainence first, burdens many with preclinical health implications & comorbidities segregates vulnerable from resilient Thriving cities are epicenter to globalization some among the presymptomatic cases become #superspreaders

11
#Reiterate
Simple task to #Containment is challenged due to conditioning, dereliction of duty, trust deficit by overconfident, rebellious, wilfully ignorant & polarized as they avoid wearing a mask, hand washing or follow social distancing thus viral contagion causing mayhem

12
Many nation states are unprepared unable to comprehend the consequences as we move along new learning curve facing overwhelmed medical systems with glaring inadequacies while chaos derails efforts As new information collates to existing guidelines causing #Confusion to masses

13
Nation states vigilant with cohesive, cooperative population, proactive approach & prudent economic sense will prevail in #Crisis
While ones with unfair economic burden, social divide, vulnerable system, huge underprivileged & dependent VICTIM population might face long wrath

14
Virus spares none from childhood to infirm attacks #faultlines VICTIMS of circumstances affecting individual, family & economy Society's VICTIMS of unfairness suffer the most
Virus finds even match in resilient subject those having reserves to overcome crisis without turmoil

15
Fast pace indulgence erodes functional might to organ systems with added #liabilities as lifestyle stress, chronic oxidative damage, proinflammatory states, ⬇️lung Compliance, COPD, CKD, CAD, CVD, metabolic endocrine syndromes accelerates aging Obesity HTN DM are most targeted

16
covid19 patient faces #ostracisation
irrespective of status, risk suffering emotional neglect, isolation & oblivion Barrier disease creates can shatter personal moral Avoidance & shunning is a sad reality to patient care reflecting infectivity & prevailing fear to the disease

17
Viral pathophysiology in lungs is a spectrum➡️ alveolo-capillary membrane targeted, alveolar damage, surfactant loss, capillary stasis precipitating thrombosis
Varied lung dysfunction decompensatation progresses to system dysfunction, systemic shock #MODS thus risk to life

18
#Supportivetreatment is mainstay assisting & fine tuning respiratory efficiency with NFO2 & steroids Not a single drug really has passed double blind #RCT against covid & approved Comorbidity & system reserves of individual person ultimately decide disease course & prognosis

19
Hope our effort works with #vaccination same as those who recovered from natural infection Post vaccination ones exposed to virus might respond as per innate & acquired immune memory Very fact those prone with disregulated immune might & sensitized system will remain at risk

20
covid19 is a puzzle yet to decipher, medical scientists are focusing on #Missinglinks trying their best with objective findings as a team work to defend vulnerable & fight covid head on as moral duty beyond responsibility by offering most relevant care to the present context

21
Health fraternity is overwhelmed with burnout trying best to save lives, virus attacks healthcare staff, doctors & enforcers #Highriskproviders loose life in the line of duty, despite this frontline workers put collaborative effort to manage patients with evolving consensus

22
#Leaders are expected to focus, empower & act in this carnage with earnest priority to save lives over economy A TASK to unprepared system as social divide, moral decline & trust deficit foster anarchy which ails society, brunt is being faced by commoner VICTIMS of situation

23
Contextually there are too many social variables introcept, amend mistakes, prioritize family, contribute as citizen, restrict casual movement, control lifestyle needs, shun desires inciting stress #Moralobligation to citizens is to be vigilant & protect SELF first

24
Viral inflicton is beyond social construct, overcome ignorance, have gratitude to where we are, prioritize life pursuits #Responsibility is to respect health Contentment is to recognize freedom #Focus on compassionate relationship, emulate moral values to instill upbringing

25
As citizen now is time to rise, forget differences, work unitedly in the hour of crisis to protect vulnerable, alleviate their suffering, be supportive & SEEK EARLY HELP This challenge expects us to amicably mould & entrust faith on able #MEDICALLEADERS to control pandemic