Hearings today @US_FDA on @pfizer application to give 3rd doses of #COID19 #vaccines . Much rests on the Israeli findings. Two reps of their MOH presented details, which are significant because Israel's mass vax is abt 3 months ahead of Europe & UK & USA.
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2/ Israel 1st rolled out mass vax in December, and the impact against routine forms of #COVID19 was excellent. It seemed that a standard @pfizer #vaccine protocol worked beautifully.
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3/ But then, Israelis told @US_FDA , the #DeltaVariant slammed Israel and #COVID19 incidence in all age groups, including among fully vaccinated, soared. The question was why.
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4/ The soar in #COVID19 incidence after 2-dose vaccination in Israel could have been caused directly by #DeltaVariant or cld mean the @pfizer #vaccine protection was waning, weakening.
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5/ It was urgent that Israel figure out why #COVID19 was soaring despite mass 2-dose vaccination, because projections showed that by Sept., if unabated, the epidemic would overwhelm the nation's medical capacity. If waning immunity was key, a 3rd dose might stop it.
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6/ The Israelis were convinced that the efficacy of the @pfizer #vaccine was waning over time, especially in people over 60 years of age. They felt there was a clear decrease 6 mos after full vax.
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7/ So in July Israel started a mass 3rd-dose vax campaign, initially targeting the >60 yr old population. This chart shows levels of protection against #COVID19 infection, starting on the left w/only 2 doses & then weeks after 3rd dose.
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8/ The 3rd dose ushered a bug drop in #COVID19 hospitalization rates in >60 yr olds. TEN-FOLD decline.
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9/ The incidence of new #SARSCoV2 infections plummeted after 3rd dose administration to Israelis >60 yrs of age.
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10/ As the Israelis lowered the ages on people targeted with 3rd doses of @pfizer #COVID19 #vaccine they saw an impact on the epidemic overall -- the reproductive rate (Ro) dropped radically, they told science advisors to @US_FDA this morning.
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11/ The Israelis told the @US_FDA mtg this morning that the overall impact on Israeli society of widespread use of a 3rd dose of @pfizer #COVID19 #vaccine has been dramatic.
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12/ This summarizes Israel's analysis of 3-dose #COVID19 immunization with the @pfizer #vaccine.
The @US_FDA scientific advisory board is meeting all day. Stay tuned.
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