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Laurie Garrett Profile picture
@Laurie_Garrett
Sep 17, 2021 • 12 tweets • 11 min read • Read on X
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Hearings today @US_FDA on @pfizer application to give 3rd doses of #COID19 #vaccines . Much rests on the Israeli findings. Two reps of their MOH presented details, which are significant because Israel's mass vax is abt 3 months ahead of Europe & UK & USA.
MORE
2/ Israel 1st rolled out mass vax in December, and the impact against routine forms of #COVID19 was excellent. It seemed that a standard @pfizer #vaccine protocol worked beautifully.
BUT, MORE
3/ But then, Israelis told @US_FDA , the #DeltaVariant slammed Israel and #COVID19 incidence in all age groups, including among fully vaccinated, soared. The question was why.
MORE
4/ The soar in #COVID19 incidence after 2-dose vaccination in Israel could have been caused directly by #DeltaVariant or cld mean the @pfizer #vaccine protection was waning, weakening.
MORE
5/ It was urgent that Israel figure out why #COVID19 was soaring despite mass 2-dose vaccination, because projections showed that by Sept., if unabated, the epidemic would overwhelm the nation's medical capacity. If waning immunity was key, a 3rd dose might stop it.
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6/ The Israelis were convinced that the efficacy of the @pfizer #vaccine was waning over time, especially in people over 60 years of age. They felt there was a clear decrease 6 mos after full vax.
MORE
7/ So in July Israel started a mass 3rd-dose vax campaign, initially targeting the >60 yr old population. This chart shows levels of protection against #COVID19 infection, starting on the left w/only 2 doses & then weeks after 3rd dose.
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8/ The 3rd dose ushered a bug drop in #COVID19 hospitalization rates in >60 yr olds. TEN-FOLD decline.
MORE
9/ The incidence of new #SARSCoV2 infections plummeted after 3rd dose administration to Israelis >60 yrs of age.
MORE
10/ As the Israelis lowered the ages on people targeted with 3rd doses of @pfizer #COVID19 #vaccine they saw an impact on the epidemic overall -- the reproductive rate (Ro) dropped radically, they told science advisors to @US_FDA this morning.
MORE
11/ The Israelis told the @US_FDA mtg this morning that the overall impact on Israeli society of widespread use of a 3rd dose of @pfizer #COVID19 #vaccine has been dramatic.
MORE
12/ This summarizes Israel's analysis of 3-dose #COVID19 immunization with the @pfizer #vaccine.
The @US_FDA scientific advisory board is meeting all day. Stay tuned.

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More from @Laurie_Garrett

Laurie Garrett Profile picture
Sep 23
Donald Trump is now addressed the UN General Assembly. He notes the teleprompter isn't working and, "whoever is responsible for this teleprompter is in big trouble."
He reads from printed text on the podium.
"This is the Golden Age of America." Image
2/ His remarks open by listing his accomplishments domestically since taking office. "In my first term I built the best economy in the history of the world...and this time it's even better."
"The number of illegal aliens entering our country has reached zero...If you come illegally into the U-S you're going to jail...or perhaps further. You know what that means."Image
3/Trump at UNGA
Says the U.S. was a laughing stock, but not anymore. My administration has negotiated one historic trade agreement after another."
I have ended 7 un-endable wars. I ended 7 wars. " Cambodia/Thailand, Congo/Rwanda, Armenia/Azerbaijian, Albania/Kosovo.
"And I did it in just 7 months. There's never been anything like it."
The UN "did nothing. I never even received a phone call from the U-N."Image
Read 18 tweets
Laurie Garrett Profile picture
Sep 22
Canadian PM Mark Carney is addressing the Council on Foreign Relations right now. He opened by describing the very positive relationship Canada and the US shared -- until now.
And looking at Trump impacts on the global geopolitical landscape.
"So, what do we do about it? We think we can thrive for three reasons"
1.) we have what the world wants:
- energy
- we are top % in world's critical minerals
- we are a leading developer of AI and quantum talent
- we have sophisticated pension funds and investors
- we have a govt that can act decisively
2.) Our public square is loud, diverse and free
3.) We recognize what's going on. A rupture. Sharp change.
- build strength at home, cut taxes, increased X-province trade, doubling defense spending, especially in AI
- defend out values
- build alliances abroad
- diverse trade agreements, espec. w/EU
- joining SAFE -- EU defense
- comprehensive approach w/Mexico trade
- we are largest contributor per capita to Ukraine
- support 2-state solution in ME
- forming buyers' clubs for REEs & critical minerals

MORE
Carney/2
"Old Multilateralism" -- how we used to work.
Now, substantial change underway, espec. for REEs, essential minerals, energy.
When you think about Canada, think of a strong soveriegn nation.
We understand what's going on. We have the resources the world needs. We're a reliable partner...with any part of the world.
Carney/3
LIVE now Carney is talking on stage w/CFR Pres. Froman
Q - 2/3rds Canadian population lives w/in 100 km of US border -- how much can you reorient economy?
Carney: 1st, recog. the need to do it. To be masters in our own house.
Don't want to look at Truth Social daily to see changes in US poilicy
MORE
Read 21 tweets
Laurie Garrett Profile picture
Aug 31
On Friday, when most of America wasn't paying attention, heading out for the holidays, Trump signed an Exec Order transferring ALL control over foreign aid from State to OMB.
This will destroy American overseas programs. Here's why (MORE)whitehouse.gov/presidential-a…
2/US programs for everything from #famine relief & #HIV care to safe pregnancy efforts & building electricity grids have won America friends in the world & saved 100s of millions of lives. They were nested in the State Dept so our diplomats on the ground can oversee them.
MOREImage
Image
3/ By moving foreign aid out of State & into OMB, programs for saving starving children, rescuing families from catastrophes, teaching kids to read, stopping epidemics -- ALL of that now falls under the control of Russell Vought.
Who is Vought?
MOREtrumpwhitehouse.archives.gov/people/russell…Image
Read 22 tweets
Laurie Garrett Profile picture
Jul 19, 2024
As #JoeBiden hunkered down in Delaware & Party leaders scrambled to figure out how #Democrats can win the election, I kept thinking of March 31, 1968. On that day the White House put out word of a mysterious speech LBJ would give from the Oval Office.
MORE
@BeschlossDCImage
2/
 In a world without Internet or 24-hour news cycles the buzz in Washington about the event failed to reach the American people until that night. America assumed LBJ’s address would be about the widening war in Vietnam. On live television, a very haggard-looking LBJ began:
MORE Image
3/
 "Good evening, my fellow Americans:
Tonight, I want to speak to you of peace in Vietnam and Southeast Asia.
No other question so preoccupies our people. No other dream so absorbs the 250 million human beings who live in that part of the world."
MORE Image
Read 16 tweets
Laurie Garrett Profile picture
Jul 9, 2024
While #Trump claims no direct connection to #Project2025 it's clear han no #Republican in national power has denounced the Heritage Foundation 887-page manifesto. I put a few hours into scrutinizing the Project's plans for @HHSGov & health agencies. (pages 449-502)
🧵unfolds: Image
2/Health & Human Services @HHSGov must “respect for the sacred rights of conscience” for Federal workers & healthcare workers broadly who object to #Abortions contraception, gender reassignment & other issues.
“Radical actors inside & outside govt are promoting..."
MORE Image
3/ “...harmful identity politics that replaces biological sex w/subjective notions of 'gender identity' & bases a person’s worth on his or her race, sex, or other identities. This destructive dogma, under the guise of 'equity,' threatens American’s fundamental liberties..."
MORE Image
Read 17 tweets
Laurie Garrett Profile picture
Jul 5, 2024
When a society attacks its toiling scientists, ranking the opinions of quacks, religions & charlatans above those of scientific insight and discovery, it is a sorrowful time.
Scientists who have been persecuted for their work...
MORE
2/
 -Muhammad ibn Zakariyā Rāzī or Rhazes of Baghdad (860 - 932 AD) beaten into blindness for introducing medical advances from non-Arab countries
MOREImage
-Michael Servetus (1511-1553) made discoveries in blood circulation. Burned at the stake by Calvin in Geneva
-Henry Oldenburg (1619-1677) promoted sharing scientific insights, labelled a spy, held in the Tower of London
MOREImage
Image
Read 11 tweets

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