Not sure which is more surprising:
1. Finally a breakthrough in treating pancreatic cancer, or
2. The treatment is chloroquine.
1. Finally a breakthrough in treating pancreatic cancer, or
2. The treatment is chloroquine.
Chloroquine is an inhibitor of autophagy, the mechanism a celll uses to clear proteins it doesn’t want. What’s novel here is what happens when you combine it with immune checkpoint inhibitors, but I couldn’t resist 😉
Autophagy is the means by which pancreatic cancer cells limit the amount of MHC class I molecules on their surface, so they can hide from the immune system. Inhibiting autophagy exposes the the cancer cells, like lifting an invisibility cloak 👍
Do not combine with disinfectants.
