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Scientists love big challenges. And this is the biggest one yet.
The #COVID19 vaccine challenges, reviewed by Michael Diamond and Theodore Pierson @WUSTLmed
cell.com/action/showPdf… @cellhostmicrobe
Here, Dennis Burton, my brilliant vaccinologist colleague and friend @scrippsresearch & Laura Walker adimab.com
lay out the design rationale w/ some optimism + prudent caution
cell.com/action/showPdf… @cellhostmicrobe @CellPressNews
I could've highlighted every word
For more on the rapid progress on #SARSCoV2 vaccines this thread/subthread
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Eric Topol
@EricTopol
Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍
cell.com/cell/fulltext/…
There have been 2 prior reports (both @ScienceMagazine) isolating neutralizing antibodies, each from a single patient w/discovery of key epitopes +cryo-EM structure. This report goes well beyond those w/ sc-RNA seq of B cells *60* patients, model efficacy, best nAb paper to date
Here are the links to the 2 prior @ScienceMagazine papers:
science.sciencemag.org/content/sci/ea…
science.sciencemag.org/content/early/…
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
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Eric Topol
@EricTopol
What's the chances that these 13 serology tests given EUA approval by @US_FDA (as of today) have anywhere close to 100% specificity claimed?
Zero.
csb.mgh.harvard.edu/covid @WeisslederLab
Or how about the 75 #COVID19 tests the @US_FDA has given EUA approval?
Where are the data for accuracy?
Oh, I, see it's "NA"
This is frankly pathetic, FDA. You have given us test anarchy.
And you shutdown @UWMedicine
That is shameful.
BTW, NA=not ascertainable
These tests w/ limited data -> commercial runway to be used widely-> potential misinformation
Example: false negative rate @AbbottGlobal (used by @WhiteHouse) may be as high as 50%. Now, after release March 27, FDA investigating:
latimes.com/science/story/…
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Eric Topol
@EricTopol
That people can have #COVID19 without symptoms is one of the most challenging aspects of preventing spread.
A recent preprint meta-analysis says the rate is 16% medrxiv.org/content/10.110…
But we (@danieloran and I) believe it is >30%.
scripps.edu/science-and-me…
Which is right?
1/x
It's unclear. But first let's review the meta-analysis.
They found 460 studies and winnowed it down to 5 (1%), for various reasons 2/x
The only 5 included are here. These are rated for different biases, but not included was whether they're of a representative population (1/5?)
A goal was to have some follow-up of the people to be sure that they weren't actually pre-symptomatic, which is the big confounder
3/x
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