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Why do so many people sail thru #SARSCoV2 infection, without or only mild symptoms?
Work/testing to date has focused on B cells-> antibodies
But there's also a T cell story of response to other coronaviruses, suggested by a new @CellCellPress paper today
cell.com/action/showPdf…
After being antibody-centric, the role of T cells, and their significance, for taking on #SARSCoV2, is getting spotlighted
sciencemag.org/news/2020/05/t… @ScienceMagazine w/ @angie_rasmussen
medrxiv.org/content/10.110…
That 2 patients could recover from pneumonia without ability to make antibodies, but with a solid T cell repose, further emphasizes the role of cellular immunity in combatting #SARSCoV2
onlinelibrary.wiley.com/doi/epdf/10.11…
via @rfsquared
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Eric Topol
@EricTopol
Why have active cigarette smokers been consistently shown to have relative protection from #COVID19?
A new paper @Dev_Cell shows a substantial increase of ACE2 expression that is dose-dependent, by @JSheltzer @CSHL @joans @Google and colleagues
cell.com/action/showPdf…
Some have questioned my assertion of cigarette smoking offering relative protection
There are several references, but here is the latest @TheLancet and many more like this
thelancet.com/pdfs/journals/…
Let me add I’d be the last person in the world to support cigarettes or find anything that supports their use. There’s a paradox here with the new @Dev_cell paper. Others have suggested nicotine interactions. A lot more to learn on this topic
Read 4 tweets
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Eric Topol
@EricTopol
The historic, botched operation
@NewYorker,masterful by Barry Bliss
Correction: I botched Barry's last name. It's Blitt.
The operation failed.
And so did the drug.
@PostOpinions
Read 4 tweets
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Eric Topol
@EricTopol
Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍
cell.com/cell/fulltext/…
There have been 2 prior reports (both @ScienceMagazine) isolating neutralizing antibodies, each from a single patient w/discovery of key epitopes +cryo-EM structure. This report goes well beyond those w/ sc-RNA seq of B cells *60* patients, model efficacy, best nAb paper to date
Here are the links to the 2 prior @ScienceMagazine papers:
science.sciencemag.org/content/sci/ea…
science.sciencemag.org/content/early/…
This work will accelerate nAbs and vaccine devp't.
I think nAbs have the best short term shot for making an Rx difference
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