@MBVanElzakker Hey just to explain why Mike’s comment resonates w/ me, I’m not against adenovirus vectors (AAVs), but I hope b/c they are very new, and b/c no current vaccine uses them…that we are extremely careful moving them forward
@MBVanElzakker 2/ There is some concern over long-term safety of AAVs. Eg: here, in dogs w/ hemophilia treated w/ AAVs 10 yrs earlier, AAV-associated DNA integrated in the genome of the dogs’ liver cells, sometimes near genes affecting cancer growth: sciencemag.org/news/2020/01/v…
@MBVanElzakker 3/ Also, adenoviruses are sometimes described as fairly innocuous by teams working on vaccine development but adenoviruses have been found in tumors (nature.com/articles/s4158…) in the Alzheimer’s brain (pubmed.ncbi.nlm.nih.gov/29937276/) 
@MBVanElzakker 4/ …and are some the first viruses to expand in immunocompromised patients w/ HIV: ncbi.nlm.nih.gov/pmc/articles/P…
@MBVanElzakker 5/ So we need to understand that adenoviruses may contribute to serious human chronic disease, and carefully attenuate them for vaccine development w/ that knowledge in mind
