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Thank you @PlzSolveCFS for including me this video that helps people better understand the devastating and debilitating disease #ME/CFS: m.youtube.com/watch?v=LPUxt3… Image
2/ A growing body of evidence indicates thst #ME/CFS involves neuroinflammation, possibly connected to the activity of #viral pathogens capable of persisting in the central nervous system (CNS): frontiersin.org/articles/10.33…
3/ There have been dozens of #ME/CFS #outbreaks over the years, many connected to #enteroviruses, coxsackie #viruses and even respiratory viruses (w/ enterovirus found in the brain of patients via autopsy in some cases) Image
4/ Since #ME/CFS symptoms can begin after #infection w/ a respiratory virus, better studying the illness may inform #COVID-19 research as well, especially b/c in some cases Coronaviruses can enter the CNS: pubmed.ncbi.nlm.nih.gov/24619619/
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#ME #viral #outbreaks #enteroviruses #viruses #infection #COVID

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Amy Proal
@microbeminded2
Hey! I have some thoughts on the paper below that attempts to position #ME/CFS as an “autoimmune disease” by associating 2 SNPs with very small odds ratios to differences b/t infectious & noninfectious disease onset (OR=0.54 & OR=0.64): frontiersin.org/articles/10.33…
2/ The team didn’t study the #ME/CFS immune response itself, but instead measured several common #SNPs associated w/ certain “autoimmune” conditions in their ME/CFS subjects. For example SNPs in the gene PTPN22 (connected to #Crohn’s, type 1 #diabetes etc)
3/ PTPN22 is a gene that, in simple terms, plays a role in regulating B and T cell activity. It’s actually just a gene that impacts the immune response (there doesn’t HAVE to be anything “autoimmune”-inducing about PTPN22 activity)
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Amy Proal
@microbeminded2
This study found that Epstein Barr #Virus (EBV) IgM antibody seropositive #COVID-19 patients had a 3.09-fold increased risk of fever compared to EBV seronegative patients. Inflammatory markers like C-reactive protein were also higher in the EBV+ patients: researchsquare.com/article/rs-215…
2/ The study is a small, but good example of the how already-acquired persistent #pathogens can influence how a person responds to a new #infection: the existing pathogen(s) might cause additional symptoms or influence how the #immune system can respond to the new infection
3/ For example this study found that persistent Cytomegalovirus (CMV) infection caused ~10% of all T cells in CMV+ individuals to be directed against that virus. Could harboring CMV then change how the adaptive immune system responds to COVID-19?: ncbi.nlm.nih.gov/pmc/articles/P…
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Amy Proal
@microbeminded2
I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients
2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”
the-scientist.com/news-opinion/l…
3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”
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