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Elegant, extensive #3D structural biology of #SARCoV2's polymerase, cryo-EM mapping its replication machinery, and remdesivir binding, published @CellCellPress today
cell.com/cell/fulltext/…
This work follows on unparalleled velocity of high quality structural biology of #SARSCoV2 and neutralizing antibodies (from patients). It will help in drug, antibody and vaccine devp't. If you can't keep all the "NSPx's straight, the @NEJM figure might help!
Yet another paper @nature today
nature.com/articles/s4158… on the #SARSCoV2 polymerase!
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Eric Topol
@EricTopol
On the day that the United States reached the 100,000 death toll by @JHUSystems:
All in < 90 days. (February 28th was the 1st)
The country stands alone in the world —not just on this graph of loss of American lives—but also as the only country with no plan.
Most of the 1st 100,000+ deaths were unnecessary.
First there was no testing capacity for 60 days
So No #TestTraceIsolate to get ahead of it.
Then there was delayed stay-at-home, mitigation.
Now another 100,000 deaths are projected in 90 days
With no national, coordinated plan
The next 100,000 deaths projection.
Where are we?
Without: leadership, massive testing & tracing capability, any accountability
With: premature reopening
Watching the loss of our fellow Americans as if we're in the 3rd world. Helpless. It's beyond belief.
Read 3 tweets
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Eric Topol
@EricTopol
A cruise to Antartica
217 passengers + crew
128 (59%) test positive for #COVID19 infections
But only 24 (19%) became symptomatic
The other 104 (81%) remained without symptoms
Another cohort showing the high frequency of asymptomatic infections
thorax.bmj.com/lookup/doi/10.… @ThoraxBMJ
A hospital in the UAE screening its patients with cancer, without #COVID19 symptoms
7 of 85 (8%) were positive. But they all subsequently developed symptoms. Highlights presymptomatic admixture and also screening in high-risk patients
@JAMAOnc
jamanetwork.com/journals/jamao…
fixed link: thorax.bmj.com/content/early/…
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Eric Topol
@EricTopol
The success of Japan with a *unique strategy*, emphasizing attention to super-spreader venues and the 3 C's (closed spaces, crowds, and close-contact settings). Little testing, no lockdown.
sciencemag.org/news/2020/05/j… @NewsfromScience @ScienceMagazine
Whatever they did in Japan worked a lot better than the US, like ~2 orders of magnitude better
@OurWorldInData
Japan's performance (or model) is also working better than Sweden's (and the other Nordic countries), per million people
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