Tom Bollyky Profile picture
Jul 1, 2020 18 tweets 12 min read
6 months into #COVID19, our best measures of pandemic preparedness have not been correlated w/fewer deaths

In fact, nations w/higher JEE, GHSI, and #UHC scores have had *higher* death rates, even accounting for age structure & timing of 1st case

why? 1/
#COVID19 has revealed that we don't yet understand how best to measure countries' capacity to respond effectively to severe pandemic threats

this admittedly wonky thread is based on new @ThinkGlobalHlth post looking at JEE, GHSI & #UHC in this pandemic 2/
thinkglobalhealth.org/article/all-be…
First a bit of background on the different measures of pandemic preparedness 3/
Following the 2014–16 Ebola epidemic in West Africa, @WHO & partners developed Joint External Evaluation (JEE) process to monitor countries’ adoption and implementation of the core capacities under the International Health Regulations 4/

who.int/ihr/procedures…
More than one hundred nations have undertaken voluntary Joint External Evaluations

This super helpful @ResolveTSL tool combines the results into a single score for each country, based average score of 19 preparedness areas measured by JEE 5/ preventepidemics.org/map/
Another metric, the 2019 Global Health Security (GHS) Index go beyond JEE.

It's a comprehensive assessment & benchmarking tool that measures country capacity to rapidly respond to & mitigate spread of an epidemic 6/
ghsindex.org/about/
Universal health coverage (UHC), a measure of access to quality health services and protection from hardship, is another metric for which many have advocated as a potential means of improving #globalhealth security 7/
gh.bmj.com/content/bmjgh/…
But when you look at a consistent measure of performance none of our metrics have done well

This figure compares JEE readyscore w/cumulative reported, age-standardized #COVID19 deaths per 100k people in 50 days following date of first death in that country

No correlation 8/
The same is true of the Global Health Security Index

This figure shows overall GHS Index score, but we ran same comparison on more specific indicators from index, such as the “Rapid Response to and Mitigation of the Spread of an Epidemic”

Got similar results 9/
#UHC has so far not fared any better

Several countries that acted quickly to contain #COVID19, (eg South Korea & Taiwan) have high levels of universal health coverage. But same is true for many that have struggled in this pandemic, including Italy and United Kingdom 10/
Note: the UHC data we use comes from here 11/

thelancet.com/journals/lance…
One answer is that JEE, the Global Health Security Index, and measures of #UHC are not meant to predict health outcomes

They are important tools for identifying gaps in capacity and mobilizing financial and political support to fill those gaps 12/
Francis Fukuyama argues in @ForeignAffairs: capacity is 1 of 3 essential ingredients to nations’ success in #COVID19 pandemic—effective leadership and a government that citizens trust and listen to must also be in the mix

That insight rings true 13/ foreignaffairs.com/articles/world…
But in that formulation, you would expect capacity to be necessary, but not sufficient for success against #COVID19

At least as measured by JEE, GHSI, & UHC, that has not *so far* been case. Look at Vietnam 14/
My coauthors --Joe Dieleman, Sawyer Crosby @IHME_UW & @samckiernan -- and me are not first to observe this disconnect between capacity & #COVID19 performance

@udnore, Ahmed Razavi, & @DrEmeruemJnr wrote this on the GHS Index in @GlobalHealthBMJ 15/ gh.bmj.com/content/5/4/e0…
Independent Oversight and Advisory Committee for the @WHO Health Emergencies Program (h/t @JeremyKonyndyk) observed this too on JEE 16/

who.int/about/who_refo…
The contribution of this @ThinkGlobalHlth post is visualizing that disconnect with regard to #COVID19 deaths, extending analysis to #UHC, and accounting for national differences in population age-structure and the timing of the epidemic 17/

thinkglobalhealth.org/article/all-be…
To end this long thread:

#COVID19 suggests as we scale up investments & create funds to help countries prepare for future epidemics, we also need to think more a/b how we measure preparedness & combine w/efforts to foster readiness & implementation 18/18
thinkglobalhealth.org/article/all-be…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Tom Bollyky

Tom Bollyky Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @TomBollyky

Oct 29, 2021
Developing safe & effective vaccine faster in a pandemic?

Helps but benefits only nations that can manufacture

Ensuring every region can make + administer vaccines as fast as rich nations?

Priceless.

Here's how via @JHSPH_CHS @JenniferNuzzo & me et al
bit.ly/3EwEA5n
The COVID-19 pandemic has highlighted some strengths and some significant gaps and weaknesses in this global pandemic R&D and response ecosystem 2/

centerforhealthsecurity.org/our-work/publi…
On one hand, pre-pandemic research into mRNA vaccines & public investment in COVID-19 vx R&D paid off hugely

Not one but several highly effective COVID-19 vaccines were developed, trialed & brought to market in 1 year

Previous record was 4 years (mumps) 2/
h/t @OurWorldInData
Read 23 tweets
Sep 24, 2021
Countries have pledged to donate 1.9B COVID vaccines but delivered 1.1B

@samckiernan @serena_tohme combed govt websites, COVAX docs & media reports to identify the 61 nations that have pledged, where doses are going & which nations have yet to deliver 1/
thinkglobalhealth.org/article/billio…
The US has most outstanding, but that is misleading as President Biden just this week added 500m to US total pledged donation by 1.1B COVID vaccine doses

Team Europe on the other hand...
2/
thinkglobalhealth.org/article/billio…
Team Europe (EU Norway + Iceland) added 50M to its total pledge of 500m COVID vaccine doses

While Team Europe has administered 561M doses at home, it's donated just 33.8M doses - 6.8% of total pledge

W/in Team Europe, Germany has most undelivered

UK hasn't been much better 3/
Read 11 tweets
Jun 9, 2021
Maximizing potential benefit of vaccine donations depends on doses going where they can do the"most good" but there's no consensus on where that would be

Murray @IHME_UW @RCReinerJr & I propose an approach that prioritizes epidemiology over geopolitics 1/
thelancet.com/journals/lance…
This week's summit in Cornwall, UK should be the time when G7 leaders finally act on their promises to send surplus COVID-19 vaccine supplies to the many other countries where they remain scarce #G7UK

But how will those vaccine donations be allocated? 2/
bloomberg.com/news/articles/…
COVAX has been criticized by @ZekeEmanuel @GovindPersad & others for its population-based allocation scheme that does not direct most of its early vaccine supplies to the settings at the greatest risk of otherwise having high COVID-19 death rates 3/
nytimes.com/2021/05/24/opi…
Read 9 tweets
Mar 27, 2021
Recent US pledge of 2.5 M vaccine doses to Mexico is notable:

-It's the largest single bilateral pledge of doses so far in this crisis

- It's going to a nation in great need

- It came from a democracy

Here's me in @TheAtlantic on why that matters 1/
theatlantic.com/ideas/archive/…
So far, 14 countries have donated a total of 22.5 million doses to 97 nations

Most donations outside of Asia-Pacific have been too small (150k doses or less) to meet local or global demands

2/
thinkglobalhealth.org/article/politi…
Vaccine donations are distributing fewer doses than COVAX (22.5 million v. 32 million) but they are going to more countries (97 v. 60).

Yet, many of those donations are not going to the poorer nations most in need of doses 3/

thinkglobalhealth.org/article/politi…
Read 8 tweets
Jan 20, 2021
President-elect Biden has set a goal of vaccinating 100 million Americans (30% of the population) in 100 days.

It is an ambitious, achievable goal.

Here is what that will require, via @JenniferNuzzo, Sid Baccam @IEMNews, and me in the @nytimes 1/
nytimes.com/2021/01/20/opi…
Primary constraint on vaccinating more Americans so far has not been supply

Despite production shortfalls, US still distributed close to enough doses to vaccinate average of 1M people daily

Bigger hurdles have been administration & demand 2/
covid.cdc.gov/covid-data-tra…
Reaching 1 million people per day requires expanding beyond vaccinating small number of individuals on scheduled-basis to doing more mass vaccination

After 9/11, federal gov't thought through how to vaccinate many Americans in a short time 3/
liebertpub.com/doi/pdf/10.108…
Read 10 tweets
Dec 30, 2020
Good news! Vaccine is relatively cheap, easy to produce & store, well tolerated. 3B doses projected in 2021

Haven't seen submission or decision, but MHRA reportedly approved 2 dose regimen (62% effective) & is encouraging a 1-dose regimen to speed access
Results published in Lancet indicate say this a/b 1 dose regimen

It will be interesting to see public response and distribution strategy for regimen w/lower efficacy than Pfizer/Moderna options & uncertainty about duration of protection
thelancet.com/journals/lance…
Apparently, Oxford/AstraZeneca has not even filed a submission package with EMA yet. FDA decision isn't coming soon either.

This is such an important vaccine for global access and so much is strange about how its sponsors have pursued it
reuters.com/article/us-hea…
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(