Just published @CellCellPress
"SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" cell.com/cell/fulltext/… by @karolinskainst
"SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19" cell.com/cell/fulltext/… by @karolinskainst
Unique, full spectrum study of acute and convalescent patients, family members exposed but seronegative, healthy unexposed
SARSCoV2 specific T cells present even in asymptomatic individuals, mild cases, and antibody-negative family members exposed
Important findings!
SARSCoV2 specific T cells present even in asymptomatic individuals, mild cases, and antibody-negative family members exposed
Important findings!
The dissociation of antibody (its absence) and a robust T cell response is noteworthy.
It reinforces how much we miss by focusing on antibodies out of convenience, since T cells response is only assessed in research labs
Connects w yesterday's case report 👇
Virus -, Ab -, skin +
It reinforces how much we miss by focusing on antibodies out of convenience, since T cells response is only assessed in research labs
Connects w yesterday's case report 👇
Virus -, Ab -, skin +
and goes back to the when we don't measure thread
A tipoff from April were the 2 patients reported without antibodies (X-linked agammaglobulinemia) who fully recovered from covid
onlinelibrary.wiley.com/doi/epdf/10.11…
onlinelibrary.wiley.com/doi/epdf/10.11…
More good news on #SARSCoV2 immune response, beyond T cells. Neutralizing antibodies from prior infection did the job: in a boat outbreak involving over 100 people, all those with antibodies did not manifest symptoms and were protected from reinfection.
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
