AstraZeneca just halted their vaccine because of an adverse reaction. This is a really BIG deal. An important thread about the latest on reactogenic vaccines for #Covid19 from first party sources, along with upcoming public health issues on vaccines that are coming now fast. 1/
People need to know all current coronavirus vaccines are what’s called “reactogenic” vaccines—all are “expected“ to cause adverse reactions, especially excessive immunological responses, associated signs, symptoms. Pain and fever. Much more w these candidates than flu vaccines 2/
How do we distinguish an adverse reaction and do active surveillance? With the disinformation / misinformation that comes w/ vaccines. To build active surveillance for adverse reactions will require enormous resources—i.e. what’s normal vs what is not in course of it “working” 3/
Because of what we’re seeing they do seem to be more reactogenic than what people are used to. So called Grade 3 reactions - hospitalized - Moderna’s caused this too. CDC/NIH, other orgs who will be vocal alongside this may be viewed as controlled by public / private sector. 4/
Even when we have vaccines that work, what is the national health plan? Who gets immunized when and where? Will we have a National sciences report where they recommend? Will be interesting to see who puts this in practice. Applies in U.S. and everywhere. 5/
Wonder if it’ll be decided by NHS. So far the US federal response to anything Covid19 related has been appallingly lacking, which is the sad part of this whole pandemic. Good ppl muzzled. Robust public health communication is the job of a unified federal approach, *not* states 6/
In the *end* the politicians will be right about the disease: that we’ve been victorious. But I really hate to see public health history being made like this. For those annoyed by that too the future will show the truth, regardless of what people find politically advantageous. 7/
Maybe reactogenic is in part a good thing, because your immune system is in overdrive. And it’ll be fine. TBD. But it’s gonna be much more than what people are used to. Meaning effective vaccines are going to hit some people very hard for coronavirus. 8/
When people see that a disease is bad, people will tolerate a lot. So to some extent people who are afraid will go in and get a vaccine. But the most newsworthy news prior to AZ’s news today for adverse reactions was the person from Moderna. 103 fever. Very bad reaction. 9/
The truth is that some doctors in this space thought this was amazing in itself because some thought biggest risk was that coronavirus vaccines weren’t going to work *at all*. But the administration figureheading CDC...says they’re gonna roll out November, that’s just INSANE 10/
You have to believe we are further out - on getting a vaccine - when you see these major adverse reactions in phase 3 trials like AstraZeneca. And when they do complete much more testing in further phases, all of these undiscussed issues I highlighted above, they still apply. 11/
I’m still so amazed by how many people think this is less than the flu. I wonder how many people will see that risk calculation differently going forward when they see more pain and suffering and see - and finally believe - real numbers like this attached. 12/
https://twitter.com/zorinaq/status/1303245440880537601
Vaccine trust and confidence and public information—it’s a big topic. What should we anticipate as they start being rolled out? It’s really a huge concern. There will clearly be nation-state interference - bots will throw discord (not just in one way or the other, in both). 13/
We will only see this truly ramped up when vaccines are available. But people need to know now this is going to more than a flu vaccine. Reactogenic vaccines - by their nature - are going to cause a polarization people have not yet seen with Covid19. /End
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