We’ve reached another sad milestone in this pandemic.
The US has surpassed a record of more than 60k Covid-19 hospitalizations for the 2nd consecutive day. (1/12)
But there is some glimmer of hope - a smaller percentage of people are dying now from Covid-19 than in the spring. (2/12)
cnn.com/videos/health/…
One study of the @nyulangone health system found that in the spring, 25.6% of hospitalized Covid-19 patients wound up dying. By the summer, that rate had dropped by more than 2/3rds to 7.6%. (3/12)
journalofhospitalmedicine.com/jhospmed/artic…
In England, the fatality rate was around 6% in June. By mid-August it fell to 1.5%. (4/12)
cebm.net/covid-19/covid…
Keep in mind, this measure isn’t perfect. It’s the # of deaths divided by the # of confirmed cases. At the beginning of the pandemic, the # of confirmed cases was lower because we weren’t testing as much. So death rates in the spring may have been artificially high. (5/12)
Even after accounting for that difference, it is still clear that death rates are significantly lower now. But, why? (6/12)
Part of this is because we’re seeing a drop in the average age of patients -- younger patients are more likely to have less severe disease. Today the #CDC notes more than half of new cases are in people who are under 50. (7/12)
covid.cdc.gov/covid-data-tra…
But it is also because we are now better at treating Covid-19. In the spring, one doctor described his only tools as a ventilator and a patient's own immune system. But as we learned more about this disease, it turned out that ventilators weren’t always the answer (8/12)
With Covid-19 the lungs fill up with mucus. Too much oxygen pushed into the lungs can damage already delicate lung tissue - causing leaks, swelling & other damage. Instead, doctors positioned patients on their stomachs or sides - known as proning. (9/12)
cnn.com/2020/04/14/hea…
We also developed better tools to deal with this new disease - drugs like remdesivir, monoclonal antibody treatments, blood thinners, and steroids are now all used as treatments for patients infected with Covid-19. (10/12)
cnn.com/videos/health/…
This is good news but as the number of newly infected people continues to grow, significant deaths will sadly follow, even at a lower death rate. (11/12)
According to @IHME_UW we could lose 2,250+ people a day by mid Jan. The advanced treatments can help treat, but the old, ancient measures can prevent it in the first place. #WearAMask #BeKind (12/12)

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More from @drsanjaygupta

9 Nov
I want to take a moment to explain the big vaccine news today. #Pfizer is reporting early data showing their vaccine is “more than 90%” effective in preventing COVID-19. I spoke with #Pfizer’s CEO @AlbertBourla today, as the news broke early this morning (1/10)
Remember – this is an early read from a group of independent experts, not #Pfizer itself. Who are these experts? They’re known as the data safety monitoring board. (2/10)
cnn.com/videos/health/…
What we know: out of nearly 44,000 trial participants, 94 were infected during the trial period. Here is the key finding: more than 90% of the infected cases occurred in the placebo group. Fewer than 10% of the infections occurred among those who had received the vaccine. (3/10)
Read 10 tweets
5 Oct
DAY #4 President Trump hospitalization. There's still a number of unanswered questions about the president's health. Here's what Trump's doctors have told us so far. (1/20)
cnn.com/2020/10/03/pol… Image
Dr. Sean Conley read a prepared statement Saturday morning saying Trump was diagnosed 72 hours ago, meaning Wednesday morning. Dr. Conley later changed the timeline to say the diagnosis was Thursday night. (2/20) Image
So, the timeline is still unclear, but we also don’t know the last time the president had a negative test. This is a critical detail. It allows the contact tracing of people he may have infected - and gives a clearer picture of where he is in his own disease course. (3/20)
Read 20 tweets
3 Oct
After announcing a positive Covid-19 test early Friday morning, President Trump ended the day at Walter Reed National Military Medical Center, where we are told he’ll remain for “the next few days.” (1/12)
The White House said this was being done out of an “abundance of caution.” We know, however, that he developed progressive symptoms over the day, including a fever and fatigue. Mild symptoms can turn severe quickly, especially in a vulnerable individual. (2/12)
Take the case of Boris Johnson, UK’s Prime Minister. He was diagnosed with Covid-19 back in April. He also only reported mild symptoms at first, but more than a week later was hospitalized, including three nights in the ICU.(3/12)
Read 12 tweets
13 Sep
Most people on the planet want a vaccine right now and we got some news this week that the process is speeding along. Getting a vaccine approved (or authorized) quickly will be critical, but how fast is too fast? Let’s take a look.(1/20)
cnn.com/2020/09/13/hea…
Remember EUA - stands for Emergency Use Authorization - and permits the FDA to allow the use of unapproved drugs and products to manage a public health emergency. These terms are important. These products would be “authorized” but not yet “approved.”(2/20)
fda.gov/emergency-prep…
For this pandemic - hundreds of EUAs have been issued for diagnostic tests but just two are currently being used for therapeutics - the antiviral remdesivir and convalescent plasma - donated antibodies from Covid-19 survivors. (3/20)
Read 20 tweets
25 Aug
I spoke to FDA head @SteveFDA about the decision to issue an EUA (emergency use authorization) for convalescent plasma to treat those currently infected. While promising, it’s been controversial because many say the data is inadequate. (1/11)
cnn.com/2020/08/23/hea…
Dr. Hahn told me “he should have better explained the data.” Here’s what he (incorrectly) said on Sunday night: Use of convalescent plasma reduced the risk of death by 35% and that meant if 100 people got coronavirus, 35 would survive. (2/11)
whitehouse.gov/briefings-stat…
Last night he aimed to clarify that by telling me and then tweeting: “What I should have said better is that the data show a relative risk reduction not an absolute risk reduction.” This is a fundamental difference and important to understand. (3/11)
Read 11 tweets
16 Aug
One of the questions I am getting more than any other: Am I going to send my children back to school? My three teen/pre-teen girls want to go back to school and miss their friends like many others. But there is a lot to consider when making this decision. (1/20) Image
At least 63 of 101 of the largest school districts in the country have decided to start the year with virtual learning, but our school is offering both in-person and virtual options, which leaves the decision to us. (2/20)
On one hand, our school has taken major steps to follow the CDC recommendations and is even offering testing for students. I personally visited the school to understand every safety precaution. But, all of this only works if students are diligent. (3/20)
cnn.it/2CqKWbS
Read 20 tweets

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