Our next paper: Abnormal #thyroid function is common in #takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study onlinelibrary.wiley.com/doi/full/10.11…
In this study, we compared patients with #takotsubo syndrome (#TTS) with age- and sex-matched normal subjects from the #NHANES collective and with patients affected by acute coronary syndrome (#ACS) from the AQUA FONTIS study (@StudyAqua). Main outcome measure was serum #FT4. 
With artificial intelligence / machine learning we identified two clusters of #thyroid function in #TTS and three clusters in the whole population. #AI #ML pubmed.ncbi.nlm.nih.gov/33179374/
From a physiological perspective, the two clusters represent a dual etiology of high or high-normal FT4 in TTS, impending primary #thyrotoxicosis and a high set point of #thyroid #homeostasis, corresponding to type 2 #allostatic load. #Thyroid_Allostasis onlinelibrary.wiley.com/doi/10.1111/jo…
#FT4 was elevated or high-normal in #TTS, #SPINA_GT was high in a significant subgroup, #FT3 and #SPINA_GD were relatively low. #TSH and markers for the set point (#TTSI and #TFQI) had a remarkable high dispersion, as demonstrated in binomial testing. doi.org/10.1111/joim.1…
In summary, normal #thyroid function seems to be the exception rather than the rule in #takotsubo syndrome. #Stress #cardiomyopathy has a dual etiology, an increased set point of thyroid function (stress type, #allostatic load) and increased #SPINA_GT. pubmed.ncbi.nlm.nih.gov/33179374/
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