Our next paper: Abnormal #thyroid function is common in #takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study onlinelibrary.wiley.com/doi/full/10.11…
In this study, we compared patients with #takotsubo syndrome (#TTS) with age- and sex-matched normal subjects from the #NHANES collective and with patients affected by acute coronary syndrome (#ACS) from the AQUA FONTIS study (@StudyAqua). Main outcome measure was serum #FT4. Image
With artificial intelligence / machine learning we identified two clusters of #thyroid function in #TTS and three clusters in the whole population. #AI #ML pubmed.ncbi.nlm.nih.gov/33179374/ Image
From a physiological perspective, the two clusters represent a dual etiology of high or high-normal FT4 in TTS, impending primary #thyrotoxicosis and a high set point of #thyroid #homeostasis, corresponding to type 2 #allostatic load. #Thyroid_Allostasis onlinelibrary.wiley.com/doi/10.1111/jo… Image
#FT4 was elevated or high-normal in #TTS, #SPINA_GT was high in a significant subgroup, #FT3 and #SPINA_GD were relatively low. #TSH and markers for the set point (#TTSI and #TFQI) had a remarkable high dispersion, as demonstrated in binomial testing. doi.org/10.1111/joim.1… Image
In summary, normal #thyroid function seems to be the exception rather than the rule in #takotsubo syndrome. #Stress #cardiomyopathy has a dual etiology, an increased set point of thyroid function (stress type, #allostatic load) and increased #SPINA_GT. pubmed.ncbi.nlm.nih.gov/33179374/ Image

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More from @drjwdietrich

26 Oct
Tweetorial on our new paper, part 1: #Thyrotropin (#TSH) concentration is elevated in post-traumatic stress disorder (#PTSD), reflecting an elevated #setpoint of #pituitary-#thyroid feedback control. doi.org/10.3389/fendo.…
2 | TSH correlates to #allostatic load, measured by #SIQALS 2 score. Although #TSH rises, #FT4 and #FT3 concentration don't go down. Therefore, TSH doesn't reflect #hypothyroidism, but an increased setpoint due to type 2 #allostasis. frontiersin.org/articles/10.33…
3 | #Jostel's TSH index (#JTI) correlates to the #SIQALS 2 score for type 2 #allostatic_load in a large dataset of the #NHANES collective. This supports an elevated reference input (set point) of #thyroid #homeostasis in chronic #stress. doi.org/10.3389/fendo.…
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