1/ Covid (@UCSF) Chronicles, Day 237

California hit its millionth case today. A milestone like that might seem an odd occasion to highlight the state as a national model for its Covid response. But I will.

Here's @nytimes piece marking millionth case tinyurl.com/y4e4zxnp
2/ I’m quoted in Times piece: “We’re so huge that this number can make it seem like we’re doing badly – & we are beginning to surge like the rest of the country – but in point of fact we are doing comparatively well.”

That, & what the U.S. can learn from CA, is today's topic.
3/ While CA’s numbers are going in the wrong direction, when compared to the Midwest we’re doing OK – at least not so badly that we can’t turn this thing around. The figure shows CA's per capita case rate, plotted against several Midwestern states.
4/ In other words, the Midwest may well have reached that moment of exponential growth when the entire region needs to resort to a complete shutdown. But in CA, we should be able to manage our surge with less extreme measures. We’ll come back to that after we review the numbers.
5/ @UCSFHospitals, we have 11 Covid patients, 4 on vents (Fig on L). Test positivity rate is 2.4%: 4.24% for patients with symptoms, and 0.5% for asymptomatic patients (Fig on R). All of these are worse than a few weeks ago, but represent non-exponential, manageable growth.
6/ In SF, cases = 71/day, ~2x our lowest, though only half of our summer highs (Fig L). Deaths have not begun to tick up; still 153 total. Test positivity rate 1.49%, up from low of 0.8%. 39 hospitalized patients, up from low of 21 but a far cry from summer peak of 114 (Fig R).
7/ New cases of Covid in CA are ~6K/day. That’s up from 3,500 last mth, but only 4% of today’s jawdropping U.S. total of 150,000. (Note that CA makes up 12% of U.S. population.) CA’s Covid deaths are now ~50/d, also a small fraction (3.5%) of bleak U.S. total of 1,400 deaths/day.
8/ I often look at per-capita death rates as an overall measure of how a state/region is doing. It reflects both how well its doing at preventing infections, as well as preventing pts w/ Covid from dying. CA’s death rate is 46/100K population, ~40% below the U.S. rate of 74/100K.
9/ This means that, if the U.S. had CA’s rate, we would have had 150,000 U.S. deaths from Covid, 92K fewer than the 242K actual deaths. And, as I’ve said before, if the U.S. had SF’s mortality rate (17/100K), we’d have had 56K deaths, & ~186K dead Americans would still be alive.
10/ While CA has done better than the overall nation, there has been significant regional variation. For example, LA’s Covid death rate (72/100K) is about the same as the U.S.’s average of 74/100K. And LA’s case rate (3,268/100K) is equivalent to the national rate (3,238/100K).
11/ As Joe Biden maps out a nat'l strategy for Covid, he’d do well to take some lessons from CA. Given CA’s size & diversity, Biden’s relationship with the states has some analogy to Gov. Newsom’s relationship w/ CA’s mayors & country chiefs. Because, if you think about it…,
12/ ...CA is really like a mid-sized country. CA’s population of 39M would make it the world's 37th largest country, just above Canada. And CA’s gross state product of $3.2 trillion would make it the 5th largest economy in the world, just below Germany and above the UK & France.
13/ So, just as President Biden won’t be able to enact a “national shutdown” (a sledgehammer approach suggested today by Biden task-force member @mtosterholm tinyurl.com/yy2yzhgy), CA has not enacted a one-size-fits-all response to Covid. Rather, the state has created...
14/ ... guidelines tinyurl.com/yxfwfa3t under which the counties operate. Counties are free to be more stringent than the state’s guidelines (which is what SF is doing – wisely, in my view – by closing indoor dining tomorrow tinyurl.com/yy9l3th8), but they can’t do less.
15/ CA has also taken the lead in doing things that counties can’t do for themselves, such as procuring & distributing PPE safelymakingca.org and testing covid19.ca.gov/get-tested/, as well as setting up a robust contact tracing program. tinyurl.com/y57moetj
16/ In other words, CA has taken advantage of its central authority & scale to enact a real plan: providing guidance, helping in areas in which coordination is important, & absorbing some of the political heat. It’s what a competent federal response should have been, but wasn’t.
17/ CA has avoided being overwhelmed by Covid, a major factor in its success (vs. NY in spring & Midwest now). The key has been to keep cases below level that creates vicious spirals: so many sick patients & staff that hospitals get overwhelmed & mortality rates rise; so much...
18/ …testing demand that folks can’t get tests or results take a week (rendering them worthless); so many cases that contact tracers can’t keep up. While CA has had an awful lot of cases, we’ve never hit these thresholds, which has kept the pandemic manageable & death rate down.
19/ Why has CA been generally successful? While our politics is not exactly monolithic, our leaders & people have been generally supportive of reasonable public health measures, and there’s been relatively little “give me liberty…” pushback. The hope is that the Biden team…
20/ … will create national guidelines that permit a modest amount of local flexibility, successfully promote mask-wearing (perhaps helped by the new CDC guidance tinyurl.com/y67jbypj that masks not only prevent infections in others but in the mask wearer too)...
21/ … and convince people & local politicians that, while the pressure to open up the economy is real and understandable, there can be no recovery when the virus is surging. tinyurl.com/y5jsrjoe Obviously, the politics make this brutally hard, but the Biden team has to try.
22/ Will CA continue to do OK? CA skated thru Surge 1, then things soured in June tinyurl.com/ybaoq9yf. CA’s regions varied in their ability to right the ship – Bay Area snapped back quickly, while SoCal was more badly hurt. I won’t be surprised if we see that pattern again.
23/ The vaccine news this week (90% efficacy) is terrific, and points to the possibility of a return to something approaching normal by next summer. But, while there’s a light at the end of the tunnel, we’re only half-way through the tunnel. CA has experienced plenty of tragedy…
24/ … but, notwithstanding today’s grim million-case milestone, our experience also carries some lessons for the rest of the country as we start the hard work of rolling out a national plan – unforgivably, nearly a year too late – that has a fighting chance of success. /end

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More from @Bob_Wachter

9 Nov
Covid (@UCSF) Chronicles, Day 237

Didn't plan to tweet today, but can’t resist a few quick takes on @pfizer vaccine news tinyurl.com/yygwoxwf

90% efficacy is far better than even most optimistic projections. An election analogy: these are CA results, rather than PA. (1/16)
The 90% is for preventing symptomatic disease (ie, fever, cough). But we don’t know yet how well this vaccine prevents severe symptoms that lead to hospitalizations, ICU admissions, & death. That’ll be key. It seems likely it will, but that still needs to be demonstrated. (2/16)
Now that the efficacy data are out, the next big question is safety. The need to wait two months to observe at least half the volunteers is the reason the vaccine won’t be ready to be considered by @US_FDA for an Emergency Use Authorization (EUA) until later this month. (3/16)
Read 16 tweets
9 Nov
Covid (@UCSF) Chronicles, Day 236

1/ I don’t know any scientists or clinicians who aren’t thrilled about Biden’s victory tinyurl.com/y43cwpln The only way to defeat Covid is by being frank about the challenges while following the science & evidence. Biden will do all of that.
2/ Biden is set to introduce his Covid team tomorrow, led by Obama's surgeon general @vivek_murthy, & @DavidAKesslerMD, former FDA head (& ex-@UCSF dean) tinyurl.com/y2rwyaks I know both well & am confident that they’ll be excellent leaders. (Role of M. Nunez-Smith still TBD.)
3/ Biden’s decision to announce this task force as his first major act as Prez-elect is important & strategic. He knows that if he doesn’t get the pandemic under control there’s little else he will achieve as #46.

And, it goes without saying that the administration’s success…
Read 25 tweets
6 Nov
Covid (@UCSF) Chronicles, Day 233

1/ Today was an amazing @UCSF Dept. of Medicine grand rounds. We discussed the election and its impact on Covid & healthcare with an all-star crew: @KBibbinsDomingo, @ASlavitt, and @ZekeEmanuel. The 1 hour video is here:
2/ I’d normally tweet a long summary of the chat, but I’ll be honest: between obsessively watching cable (how does @JohnKingCNN stay awake?) & refreshing this addictive swing-state calculator (tinyurl.com/y5e3lecj try it!), I don’t have the energy. So just a few take-aways.
3/ I hope you’ll find the time to watch the far-ranging discussion. We covered how a President Biden (now a near-certainty, as both PA and GA are poised to flip) will and should handle the transition and the early days of his presidency, both in terms of healthcare and Covid.
Read 14 tweets
3 Nov
Covid (@UCSF) Chronicles, Day 230

1/ @NateSilver538 & team @538politics tell us that Biden has a 90% chance of winning. If he does, many things will change, but when it comes to the unmitigated disaster that is the scourge of Covid , it’s important to avoid magical thinking.
2/ A Biden administration won’t be able to turn this thing around on a dime. So today, after an overview of the state of the pandemic (SF and then the broader nation), I’ll give you my take on how a Biden administration may approach Covid in its initial days.
3/ Let’s start with the view from SF. Given porous borders, with the rest of the U.S. surging it would be shocking to see no uptick in our numbers. So my real question is not whether we’re seeing a few more cases – we are. It’s whether the uptick is manageable, or out of control.
Read 25 tweets
28 Oct
Covid (@UCSF) Chronicles, Day 224

1/ When I walk or drive around SF, I see evidence of why Covid cases & deaths are the lowest of any big city in the U.S. Masking is near universal, Ubers & Lyfts have their windows wide open, & there are pop-up outdoor eating spaces everywhere.
2/ So, as we enter a 3rd wave that's blanketing the nation, I’ll focus today on San Francisco – specifically the question of whether SF can continue its remarkable Covid success in the face of a national surge, one far more geographically distributed than the prior two waves.
3/ I’ll go out on a limb and say yes… and hope that I’m not proven wrong.

History is with us: when all of California began to surge in June, SF was able to turn it around – whereas much of the rest of CA didn’t and was hit far harder. Ditto for the southern states.
Read 21 tweets
27 Oct
Note that as hospitals get overwhelmed – as appears to be happening in many regions – the welcome fall in mortality rates we've seen since March may erode. While some of the mortality improvements can be explained by proven benefits of dexamethasone (+/- remdesivir) and... (1/3)
... changing demographics (younger & healthier patients), much of it was due to improvements in hospital care and less overwhelmed MD and nursing staffs. If hospitals get hammered, as they were in NY in the spring, I'd expect an uptick in these mortality rates, sadly. (2/3)
Today's curves (cases top; deaths bottom) show the huge surge in cases & usual lag in deaths (though deaths starting to rise). Whether these curves ultimately rise in sync will hinge on whether hospitals & ICUs can avoid being overwhelmed. Current situation isn't promising. (3/3)
Read 4 tweets

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