📍DEVASTATING ANIMATION—Containment measures 🆚 #COVID19 case surges and hospitalizations 🏥 by state.
Hospitals are now almost full nationwide and ICU beds will soon run out. Please don’t do anything to risk spreading the virus over the holidays. Please stay safe everyone. 🙏
BREAKING—Oxford/Astrazeneca vaccine is 70% effective overall. But one of its dosing regimens of low-then-high yields 90% effectiveness.
Oxford #COVID19 vaccine cheaper than the Pfizer & Moderna vaccines, and does *not* does not require freezing transport. bbc.com/news/health-55…
2) When volunteers were given two "high" doses the protection was 62%, but this rose to 90% when people were given a "low" dose followed by a high one. Not clear why yet.
The 90% effectiveness data was "intriguing" and would mean "we would have a lot more doses to distribute."
3) There were also lower levels of asymptomatic infection in the low followed by high dose group which "means we might be able to halt the virus in its tracks," Prof Pollard said.
In the UK there are 4 million doses ready to go, with another 96 million to be delivered.
CRITICAL—a negative coronavirus test is **NOT** a ticket to freely socialize without precautions—many are dangerously misguided that it is. It does not negate quarantining, masking & distancing. Here is why 🧵. #COVID19news.yahoo.com/no-negative-co…
2) There is a virus buildup time — called incubation time—until one usually shows symptoms & viral load high enough to the reliably detected. Usually incubation is 5-6 days, but can be 1-14 days or longer. But if you test too early before viral load builds up, you’ll test neg.
3) This does not mean testing is bad—if anything we need more frequent testing. But you can test negative 4 days straight and then positive on day 5. That’s what happened to WH staff K-McEnany and S-Miller—4 negatives before 5th positive. Most people don’t have that luxury.
3) Further, noted earlier that the Pfizer & Moderna vaccines both showed better antibody binding & neutralization in vaccinated people in their P1 trials, than convalescent natural infected survivors.
Hence, another reason vaccine better than Scott Atlas’s “herd”. #COVID19
📍Reinfection worry re-emerging—another documented reinfection case - this time of a 21 year old women in South Korea. There are now officially 26 confirmed reinfections and 1 death, and 572 suspected reinfections of #COVID19. Infection is rare but not blue moon rate it seems.
3) notably, it was two different virus strains. “The spike protein D614G substitution that defines the clade “G” emerged in reinfection, while mutations that characterize the clade “V” (ie, nsp6 L37F and ORF3a G251V) were present at initial infection.” academic.oup.com/cid/advance-ar…
BREAKING—FDA has granted emergency use authorization for @Regeneron’s monoclonal antibody cocktail REGEN-COV2 (Casirivimab and imdevimab), the same drug given to Trump when he was infected with #COVID19. Only for mild/moderate cases—not hospitalized. 🧵 fda.gov/news-events/pr…
2) There are a lot of rules and FDA stipulations for REGEN-COV2 cocktail use though— cannot be used if patient on oxygen (Trump was) or hospitalized. Children must be 12 or old and weigh 40 kg or more.
3) And it’s only for those mild/moderate with “high risk of progressing to severe #COVID19”—and thus need to be defined carefully what constitutes high risk of progressing: