“The light at the end of this long, dark tunnel is growing brighter”, says @DrTedros at @who #covid19 presser. "There is now real hope that vaccines – in combination with other tried and tested public health measures – will help to end the #COVID19 pandemic.”
@DrTedros @WHO No vaccines have ever been developed this fast and the ”scientific community has set a new standard for vaccine development”, says @drtedros. "Now the international community must set a new standard for access."
@DrTedros @WHO "The urgency with which #covid19 vaccines have been developed must be matched by the same urgency to distribute them fairly”, says @drtedros. “There is now a real risk that the poorest and most vulnerable will be trampled in the stampede for vaccines."
@DrTedros @WHO To ensure mass procurement and delivery of vaccines as well as tests and treatments, the ACT-Accelerator needs $4.3 billion immediately and a further $23.8 billion next year, says @drtedros. “This isn’t charity, it’s the fastest and smartest way to end the #covid19 pandemic”.
@DrTedros @WHO "The real question is not whether the world can afford to share #covid19 vaccines and other tools”, says @DrTedros. “It’s whether it can afford not to."
@DrTedros @WHO Q about Oxford/AZ vaccine.
"I think we need to wait to see the results both on the efficacy and the safety”, says @doctorsoumya. "The AstraZeneca vaccine is also being currently trialed in many other countries, and eventually we should have data on about 60,000 patients or so."
@DrTedros @WHO @doctorsoumya "Remember we have to cover a huge number of people, billions and billions of people”, says @doctorsoumya. “We will need all the manufacturing capacity in the world to be able to do that."
@DrTedros @WHO @doctorsoumya Advantage of vaccine is stability at 2-8 degrees, says @doctorsoumya. “That of course has huge logistical advantages for transporting and delivering this vaccine to cities and towns and villages and rural areas around the world, and we hope there will be more vaccines like that."
@DrTedros @WHO @doctorsoumya Q about Christmas.
There is a tradeoff says @DrMikeRyan between "a little bit more freedom over the Christmas period, which generates a sense of confidence and a sense of joy in the community, which people need right now” and allowing virus to spread more easily again.
"There is no safe or unsafe decision. There is only higher and lower risk of the situation getting better or worse, depending on what you do", says @DrMikeRyan.
“The science is clear, the policy is not clear.”
@DrMikeRyan Q about mission to investigate #covid19 origin.
“The international team has been brought together”, says @DrMikeRyan. Names have been communicated to member states and will be publicly released. Thanks the team for allowing WHO to release their names. “That’s not an easy choice.”
@DrMikeRyan “We’ve all received our fair share of hate mail and threats”, says @DrMikeRyan. “There has been a level of attack and abuse to people involved in international science. It is not an easy space to be in right now, let me be clear about that."
@DrMikeRyan “It takes courage to be a scientist”, says @DrMikeRyan "I used to think it only took brains, but now you need to be brave and courageous as well to do science in the face of the anti-science movements that we see and the ideologic politics that has come into this process."
@DrMikeRyan Origins mission has a phase 1 with short term studies to understand how the virus started circulating in Wuhan and then longer-term studies in phase 2 building on this, explains @mvankerkhove. (Terms of reference are here: who.int/publications/m…)
@DrMikeRyan @mvankerkhove "The international team will travel to China”, says @mvankerkhove. "That is being discussed amongst the international team and the Chinese counterparts. And that will be arranged in due time."

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More from @kakape

25 Nov
This new paper on #sarscov2 transmission delves into the data from Hunan province and it is really interesting and the kind of data I would love to see more of. So a short thread science.sciencemag.org/content/early/…
The authors used a dataset of 1,178 infected individuals and their 15,648 close contacts identified in Hunan province between January 16 and April 3 and reconstructed most likely transmission chains.
Superspreading:
The paper confirms previous work showing high overdispersion (so small minority of people leading to most onward transmission): “We find that 80% of secondary infections can be traced back to 15% of #SARSCoV2 infected individuals”.
Estimate k at 0.3 Image
Read 8 tweets
24 Nov
Another week, another sad record.

Last week @WHO recorded the highest weekly numbers yet in this pandemic:
More than 4 million new cases
More than 67,000 new deaths Image
@WHO The good news is that the rapid increase in global case numbers has slowed down.

The deaths are still catching up, however. In the last four weeks reported deaths were:
45,051
54,835
59,699
67,221
@WHO The countries reporting the most cases last week:
US: >1.1 million cases (+14%)
India: >280,000 (-8%)
Italy: >230,000 (-3%)
Brazil: >200,000 (+17%)
France: >170,000 (-16%)

That mirrors the global situation with cases decreasing in Europe and increasing in the Americas.
Read 6 tweets
24 Nov
Some new data came out today on the “other” #covid19 vaccine, Russia’s Sputnik V:
Press release claims efficacy of
91,4% - 28 days after 1st shot
95% - 42 days after 1st shot

Apart from usual caveats it is important to note that this comes from analysis of just 39 infections: Image
My colleague @sciencecohen wrote about the first batch of results earlier this month and why they didn’t pass the “smell test" sciencemag.org/news/2020/11/r…
@sciencecohen In press conference Kirill Dimitriev, CEO of Russian Direct Investment Fund, says vaccine will be produced in lyophilized form to be stored at 2-8 degrees C.
Vaccine to be delivered internationally from January 2021 for up to 500 million people that year. Less than $10 per shot.
Read 4 tweets
23 Nov
A lot of questions about why lower first dose of Oxford vaccine should lead to better protection.
In press briefing just now, @ajpollard1 said: “We think that by giving a smaller first dose, that we're priming the immune system differently we're setting it up better to respond.”
“What we don't know at this moment is whether that difference is in the quality, or the quantity of the immune response”, he says. More work to do he adds. “We've already started some work this morning to try to answer some of those questions.”
Sarah Gilbert says lower first dose may mimic natural infection better. “we're a group of academics, so we're delighted to have something more academic to study on this.”
Read 4 tweets
23 Nov
Another day, another press release of important #covid19 vaccine results:
This time Oxford/AstraZeneca trial with more than 20,000 participants in UK and Brazil

70% efficacy
but:
62% after two doses given a month apart
90% if first shot is half-dose

astrazeneca.com/media-centre/p…
Vaccine can be stored and distributed more easily because it only requires normal refrigeration (2-8 degrees C)
Submission for regulatory approval being prepared now
Up to 3 billion doses could be manufactured in 2021
Data „suggest that this half dose and full dose regimen could help to prevent transmission of the virus, evidenced by lower rates of asymptomatic infection in the vaccinees, with further information to become available when trial data are next evaluated.“
ox.ac.uk/news/2020-11-2…
Read 4 tweets
22 Nov
Finally finished @deerbrian‘s book on Andrew Wakefield. Not easy finding time to read a book this year as a science journalist, but this one was a must: The inside story of uncovering one of the biggest scientific frauds of the 20th century (a friend calls it ‚journalism porn‘).
I thought I already knew most of the story behind the MMR scare, Wakefield‘s infamous, retracted Lancet paper and his anti-vax crusade. But - as usual - it turns out that the complexities and texture of real life are way more surprising and satisfying in full technicolor detail.
The book does a great job explaining all the things that were wrong with Wakefield’s work but also some aspects that I had never really understood incl. for instance Wakefield’s re-emergence as a “filmmaker”.
Read 8 tweets

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