Finishing up 2 weeks on inpatient (non-COVID, largely) service. Reflecting back, particularly in light of my friend David Weinstock's perspective on being a physician scientist involved in clinical care; nejm.org/doi/full/10.10…
My two cents
1. I had a great experience being an inpatient leukemia attending the last two weeks. Great colleagues, really touching interactions with patients and their families, and I learned a lot as always.
2. There is no doubt my clinical skills are not the same as they were out of residency/fellowship. I do 4-6 weeks of service a year, which is not the same as my clinical/clinical investigator colleagues.
3. That being said, I feel very comfortable on the wards, partially because my care is focused on a set of diseases (acute leukemias almost exclusively) I know well and which I am up to date on changes to clinical practice.
4. I also have the best damm clinical colleagues in the world on the @sloan_kettering leukemia service including people like @MarkGeyerMD Aaron Goldberg Jae Park Eytan Stein Anthony Mato Lindsay Roeker. They know things I don't know and teach me new things each rotation.
5. I also have the pleasure to round with a set of spectacular team members inc. a fellow from our program, the best APPs, superb residents, and pharmacists who constantly show us why having pharmacists on rounds is best innovation I have seen in my career WRT clinical care
6. There are plenty of things I do not know, but others do. There are things I know and see in our patients WRT leukemia care that I know and the others do not. We are a team, and I am a member of that team.
7. We have a weekly conference where all patients are reviewed by our whole group, and I email/talk/text with my clinical colleagues constantly. This is key.
8. I believe I can bring value to the care team, and that I am not out of touch with clinical leukemia care. It is harder to do than it was when I was right out of fellowship and less ensconced in the lab, but worth it.
9. I think every physician scientist will make different decisions on whether to continue limited clinical work as part of their career. I chose to continue, for a clear set of reasons.
10. First, I find value in being a doctor and part of our leukemia service, never more than during the pandemic. I get a lot of personal value out of the experience.
11. Second, I love to teach, and I find opportunities to teach residents, fellows, and APPs/pharacists about leukemia biology and therapy all the time (including dedicated teaching sessions).
12. Third, it continues to markedly impact my science and the work my lab does. We study leukemia, and the mechanisms at play in this disease, and not the other way around. Keeps me and the group grounded and centered on our primary mission.
13. Fourth, I have the chance to work with the best and brightest trainees, and in some cases initiate relationships which then continue in the lab. Some of my best lab members have been clinical fellows I met on the wards, and it clicked for us to work together.
14. Fourth, future investigators need role models who are primarily clinical, clinical investigators/trialists, and lab-based physician investigators. They need to see the paths we choose so they can forge their own path.
15. I am not sure if my feelings on this will change over time. It is harder each time to keep up with the evolving clinical literature, to devote the time away from lab to clinical duties, and to deal with the exhausting amount of paperwork/EMR/insurance crap we all deal with.
16. These are my thoughts, and my own personal perspective. I think there has to be room for everyone's view on this. I welcome other's views and hope to learn from listening to how others manage their balance...

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More from @rosslevinemd

16 Dec
Now that we have all seen some light at the end of the tunnel, how do we approach 2021 as PIs? Some thoughts on the next 6-9 months
1. Everyone is tired and weary; mentally, physically and emotionally. Whether from delays/shutdowns relating to lab/clinical research, home schooling/child-care challenges, a F&^|G pandemic->its been exhausting for everyone.
2. Everyone needs to rest and recharge, and no one (should be) going anywhere for a vacation. Don't underestimate the impact of that on our collective psyche
Read 17 tweets
28 Oct
OK tweeps, today is the day, our work on single cell analysis of clonal evolution and myeloid transformation is out, led by the best in the biz, @lindemilesphd and @bowman_rl
nature.com/articles/s4158…
1. First things first; thanks to everyone who helped us with this awesome story; @thedoctorisvin, Chris F. and Minal P. in @CHM, @Levinelab (Tiff!), @duruthy & @MissionBio, @SaraMeyerLab, @RaajitRampal , @kellybolton, @ahmetz, Michael Bowman, Adam Abate and team->thank you!
2. Please also see awesome paper by @DrKTakahashi and co at @NatureComms and preprint by Adam Abate on DNA/protein sc sequencing/tech dev. All together the collective work is so cool!
Read 22 tweets
28 Oct
Mark, so wonderful to see your work, leadership, and mentorship recognized.
1. You are the consummate scientist, and you and your group's contributions to cancer epigenetics, leukemia biology, epigenetic therapies, and immune-oncology are original, impactful, and greatly influence how we think about cancer biology and do our own work.
2. You're an amazing mentor, institutional/international leader, and colleague.
Read 6 tweets
26 Oct
Part 2 of an awesome week of great collaborative studies coming out; the Beat AML Master Trial! An amazing effort led by Amy Burd @LLSResearch , John Byrd @OSUCCC_James , Brian Druker @OHSUNews and myself @SloanKettering.

nature.com/articles/s4159…
1.This study started in a small hotel conference room at ASH 2015; a group of us got together and wondered if it was time for a genomic-guided clinical trial in AML. The LLS and their CEO @LouisJDeGennaro saw the possibility, and challenged us to make it happen
2.After a year of discussions including Sunday AM calls, many conversations with our amazing colleagues at the FDA, and lots of discussions with academic and industry partners->we decided to move forward and make it happen
Read 13 tweets
11 Mar
PIs. ask yourself and your lab some important questions today.
1. If someone can do their job at home (or part of their job), are you letting them do it?
2. Did you freeze down aliquots of your ongoing cell culture experiments in case you have to stop ongoing experiments?
3. Is your animal colony tightly maintained, and can a "skeleton" crew of people from the lab take turns maintaining it if needed?
4. If anyone in your group has child-care responsibilities due to school closures etc->is it clear they should go home immediately?
Read 7 tweets
22 Jan
One of the hardest things to figure out as a PI, especially a young PI, is "when to hold em and when to fold em" with respect to appealing/revising a paper with tough reviews. A few thoughts
1. Don't ever figure this out alone, or even just within your lab. Ask peers, mentors and THE EDITOR if the revision is feasible
2. If there are experiments suggested by reviewers which you feel are not reasonable or out of scope, discuss with the editor before you begin revising (and not 6 months later!)
Read 9 tweets

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