Now that we have all seen some light at the end of the tunnel, how do we approach 2021 as PIs? Some thoughts on the next 6-9 months
1. Everyone is tired and weary; mentally, physically and emotionally. Whether from delays/shutdowns relating to lab/clinical research, home schooling/child-care challenges, a F&^|G pandemic->its been exhausting for everyone.
2. Everyone needs to rest and recharge, and no one (should be) going anywhere for a vacation. Don't underestimate the impact of that on our collective psyche
3. No one is going to be doing academic travel for at least another 6 months, meaning no in person connections with dear friends, colleagues, and collaborators. My bet is fall 2021 is the slow ramp up of academic travel
4) So what do we do? My plans/thoughts
5) Painful as Zoom-a-thons are->keep/initiate joint zoom lab meetings (email me if u want to do one with us), collaborative discussions, evening zoom drinks/coffee/dessert with friends from science and non-science.
6) Set an example for your lab and take time off over the holidays, and tell us all what you did during your staycation! I have Netflix (Cobra Kai with the kids, Mandalorian), some long runs, and walks outside in NYC (and maybe in parks in NY area) planned!
7) Make scientific, profession and personal plans for you and for the lab in 2021. Make sure all are involved in the process
8) Get something for everyone in your lab as a holiday gift (we are doing lab swag, on order!), plan a lab zoom happy hour/seamless shared wings/pizza party, do some holiday oriented fun stuff!
9) When your number is up->get vaccinated.
10) Find 2 colleagues in your field you have never collaborated with and who you admire->initiate a meeting and tell them why you think their work is cool and one way you could collaborate!
11) Change one thing in how your office/home set up is arranged->monitor placement/new monitor, chair cushion, new microphone. Just to keep it fresh!
12) Find one new way to give back your expertise->give a lecture to HS students, write a tutorial on how to do the killer experiment in your lab, nominate people for awards who have long deserved recognition. or do a bunch of things like this!
13) Find one new scientific question to address in 2021 and sketch out with your lab how to do it->and then do it!
14) Do a lab logo contest, or name a lab mascot, or something else to give your group new character.
15) Order lunch/take-out from one new place every 2 weeks in your neighborhood
Add your ideas! just some of mine....
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Finishing up 2 weeks on inpatient (non-COVID, largely) service. Reflecting back, particularly in light of my friend David Weinstock's perspective on being a physician scientist involved in clinical care; nejm.org/doi/full/10.10…
My two cents
1. I had a great experience being an inpatient leukemia attending the last two weeks. Great colleagues, really touching interactions with patients and their families, and I learned a lot as always.
2. There is no doubt my clinical skills are not the same as they were out of residency/fellowship. I do 4-6 weeks of service a year, which is not the same as my clinical/clinical investigator colleagues.
OK tweeps, today is the day, our work on single cell analysis of clonal evolution and myeloid transformation is out, led by the best in the biz, @lindemilesphd and @bowman_rl nature.com/articles/s4158…
2. Please also see awesome paper by @DrKTakahashi and co at @NatureComms and preprint by Adam Abate on DNA/protein sc sequencing/tech dev. All together the collective work is so cool!
1. You are the consummate scientist, and you and your group's contributions to cancer epigenetics, leukemia biology, epigenetic therapies, and immune-oncology are original, impactful, and greatly influence how we think about cancer biology and do our own work.
2. You're an amazing mentor, institutional/international leader, and colleague.
Part 2 of an awesome week of great collaborative studies coming out; the Beat AML Master Trial! An amazing effort led by Amy Burd @LLSResearch , John Byrd @OSUCCC_James , Brian Druker @OHSUNews and myself @SloanKettering.
1.This study started in a small hotel conference room at ASH 2015; a group of us got together and wondered if it was time for a genomic-guided clinical trial in AML. The LLS and their CEO @LouisJDeGennaro saw the possibility, and challenged us to make it happen
2.After a year of discussions including Sunday AM calls, many conversations with our amazing colleagues at the FDA, and lots of discussions with academic and industry partners->we decided to move forward and make it happen
PIs. ask yourself and your lab some important questions today. 1. If someone can do their job at home (or part of their job), are you letting them do it? 2. Did you freeze down aliquots of your ongoing cell culture experiments in case you have to stop ongoing experiments?
3. Is your animal colony tightly maintained, and can a "skeleton" crew of people from the lab take turns maintaining it if needed?
4. If anyone in your group has child-care responsibilities due to school closures etc->is it clear they should go home immediately?
One of the hardest things to figure out as a PI, especially a young PI, is "when to hold em and when to fold em" with respect to appealing/revising a paper with tough reviews. A few thoughts
1. Don't ever figure this out alone, or even just within your lab. Ask peers, mentors and THE EDITOR if the revision is feasible
2. If there are experiments suggested by reviewers which you feel are not reasonable or out of scope, discuss with the editor before you begin revising (and not 6 months later!)