1/ Here’s the 3-week *retrospective* RCT mentioned by @foundmyfitness & Dr.Fahey
females drank 600μmol glucoraphanin (GR) + 40μmol sulforaphane (SF) daily, showing no goitrogenic effects or immune responses against it - contrary to what @CarnivoreMD claims
2/ in other of Dr.Fahey’s papers he averages GR’s bioavailability to 10%, so lets go with that: 40 SF + (600 GR x 0.1) = 100μmol SF in the drink
100μmol SF/daily didn’t interfere with the thyroid in 26 women (TSH, fT4, TG TPO- & TG-antibodies), 45 if you add placebo group
3/ they were 7yrs older (48 vs 41) & had a 0.8 higher TSH (4.6 vs 3.8, but neither of these differences seems to matter. these women didn’t see goitrogenic activity because too little SF made it to the tissue, not because SF isn’t a goitrogen
the dose makes the poison
4/ in the lungs however we sees lots of SF. concentration appear tissue dependent
the authors caution
“In the meantime, it may be prudent to evaluate the thyroidal safety of plant-based food supplements on a case-by-case basis...
5/ "...because the effects may vary depending on the plant used and the preparation of the extract, and therefore it may not be safe to draw conclusions from previous studies using different approaches”
should Patrick lab-test her extracts & recommend her followers do so too?
6/ returning to tissue dependent concentrations SF, lets look at the lungs where it has a chance to shine pubmed.ncbi.nlm.nih.gov/27832073/
its hormetic anti-oxidant action doesn’t lead to better breathing in an RCT of COPD patients. mechanism doesnt guarantee better hard endpoints here
7/ Fahey comes from the perspective that “The effectiveness of high consumption of plant-based diets in reducing the risk of cancer and many other chronic diseases is widely recognized” ncbi.nlm.nih.gov/pmc/articles/P…
in the video Fahey also says that the carnivore diet makes no sense
8/ he argues our dental anatomy screams omnivory. that we can eat like that doesn't mean we're omnivores. chimpanzees spend 48% of their day chewing foods, we spend 5%. our masticatory apparatus is way smaller. we also cook/process food
1.88M views for "A Mom Tried Keto Diet For 30 Days. This Is What Happened When Things Went Wrong"
"Based on the comments, an incredible amount of people missed what actually happened here...
2/ "She had a tumor in her pancreas that caused a chronically elevated level of insulin, which was constantly pushing her blood sugar below the normal range. Going keto forced her body to rely entirely on the glucose it produces itself, which your body is normally able to do..."
3/ "without problems, especially after it has adapted to using ketones for fuel for most things. Due to the chronic hyperinsulinemia, her body was not able to function normally. Going keto actually revealed an underlying medical condition that otherwise might have gone unnoticed"
3/ “Linoleic acid (LA), the major omega-6 fat in the modern diet, is the most fattening fat [ncbi.nlm.nih.gov/pmc/articles/P…]. Its flexible and delicate polyunsaturated nature is to blame. More saturated fats - rigid and robust - like the monounsaturated oleic acid or the totally
2/ the in vitro study does indeed show, as you say, that LA strongly inhibits viral replication and thus strongly drops viral load. the caveat being that this occurs at non-physiological levels that are x2-5 higher than plasma values (per my back of the envelope estimation)
3/ the n3 rat study shows that high-dose fish oil dampened inflammation too much, increasing mortality. this is analogous to when people take too much anti-inflammatories for pain, but eventually end up with paradoxically worse pain (possibly due to interference with resolvins?)