1/ Here’s the 3-week *retrospective* RCT mentioned by @foundmyfitness & Dr.Fahey
females drank 600μmol glucoraphanin (GR) + 40μmol sulforaphane (SF) daily, showing no goitrogenic effects or immune responses against it - contrary to what @CarnivoreMD claims
lets jump in
females drank 600μmol glucoraphanin (GR) + 40μmol sulforaphane (SF) daily, showing no goitrogenic effects or immune responses against it - contrary to what @CarnivoreMD claims
lets jump in
https://twitter.com/foundmyfitness/status/1331727517527404545
2/ in other of Dr.Fahey’s papers he averages GR’s bioavailability to 10%, so lets go with that: 40 SF + (600 GR x 0.1) = 100μmol SF in the drink
100μmol SF/daily didn’t interfere with the thyroid in 26 women (TSH, fT4, TG TPO- & TG-antibodies), 45 if you add placebo group
100μmol SF/daily didn’t interfere with the thyroid in 26 women (TSH, fT4, TG TPO- & TG-antibodies), 45 if you add placebo group
3/ they were 7yrs older (48 vs 41) & had a 0.8 higher TSH (4.6 vs 3.8, but neither of these differences seems to matter. these women didn’t see goitrogenic activity because too little SF made it to the tissue, not because SF isn’t a goitrogen
the dose makes the poison
the dose makes the poison
4/ in the lungs however we sees lots of SF. concentration appear tissue dependent
the authors caution
“In the meantime, it may be prudent to evaluate the thyroidal safety of plant-based food supplements on a case-by-case basis...
the authors caution
“In the meantime, it may be prudent to evaluate the thyroidal safety of plant-based food supplements on a case-by-case basis...
5/ "...because the effects may vary depending on the plant used and the preparation of the extract, and therefore it may not be safe to draw conclusions from previous studies using different approaches”
should Patrick lab-test her extracts & recommend her followers do so too?
should Patrick lab-test her extracts & recommend her followers do so too?
6/ returning to tissue dependent concentrations SF, lets look at the lungs where it has a chance to shine pubmed.ncbi.nlm.nih.gov/27832073/
its hormetic anti-oxidant action doesn’t lead to better breathing in an RCT of COPD patients. mechanism doesnt guarantee better hard endpoints here
its hormetic anti-oxidant action doesn’t lead to better breathing in an RCT of COPD patients. mechanism doesnt guarantee better hard endpoints here
7/ Fahey comes from the perspective that “The effectiveness of high consumption of plant-based diets in reducing the risk of cancer and many other chronic diseases is widely recognized” ncbi.nlm.nih.gov/pmc/articles/P…
in the video Fahey also says that the carnivore diet makes no sense
in the video Fahey also says that the carnivore diet makes no sense
8/ he argues our dental anatomy screams omnivory. that we can eat like that doesn't mean we're omnivores. chimpanzees spend 48% of their day chewing foods, we spend 5%. our masticatory apparatus is way smaller. we also cook/process food
9/ 5% chewing time is only possible with a nutrient & calorie dense animal food diet! thepaleodiet.com/are-humans-car…
@foundmyfitness & Fahey are right about the paper's data, but omitted
-Retrospective nature
-Author's acknowledging SF as a goitrogen
-Author's cautionary calls
@foundmyfitness & Fahey are right about the paper's data, but omitted
-Retrospective nature
-Author's acknowledging SF as a goitrogen
-Author's cautionary calls
8/
6/
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