Our new pre-print is out @biorxiv_immuno! We studied #SARSCoV2 specific #Tcells in asymptomatic infection. Two important messages:
https://twitter.com/biorxiv_immuno/status/1332508555417686017
Within the first month after infection, the magnitude and pattern of the SARS-CoV-2 specific T cell response was similar to COVID-19 patients; however, their frequency seems to decrease slightly faster. 
We studied the functionality of SARS-CoV-2 specific T cells in a slightly unconventional, but maybe more meaningful way, by stimulating them with SARS-CoV-2 peptides directly in whole blood.
Unsupervised clustering completely separated the cytokine secretion profiles of symptomatically and asymptomatically infected individuals, especially shortly after infection.
Stimulation of SARS-CoV-2-specific T cells in whole blood of asymptomatic donors induced secretion of high levels of IFN-γ and IL-2 with a proportional secretion of IL-10 and pro-inflammatory cytokines (IL-6, TNF-α and IL-1β).
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