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Bertoletti Lab Profile picture
Bertoletti Lab
@bertoletti_lab
Immunologists hunting HBV @dukenus. Developing TCR-T cell therapy against viral-related cancers and studying HBV-host-immunity. Tweets by Nina Le Bert
Jan 27, 2022 • 5 tweets • 1 min read
Are antibodies the only selection force that shaped SARS-CoV-2 variants? Or can T cells also play a role? Recent works showed substantial preservation of the ability of T cells to recognize SARS-CoV-2 VOCs, suggesting that T cells might not play a role in viral evolution. Our new manuscript challenges this interpretation that is also undermining the importance of T cells on viral control. Our data confirmed that global vaccine- and infection-induced Spike-specific T cells largely tolerate a wide number of mutations present in VOCs.
Nov 27, 2021 • 13 tweets • 3 min read
So, there is a new variant Omicron (B.1.1.529)
30AA substitutions, 3 deletions, 1 insertion in the Spike protein
Great concern about escaping Spike-specific antibodies!
This is important; but what about T cells? They might not protect from infection, but likely from disease: 🧵 Premise: T cells recognize short parts of viral proteins (~9-14AA) on the surface of infected/antigen-presenting cells. Everyone has its own T cell repertoire recognizing many different regions of Spike. Some might be affected by mutations: What we know about T cells and Omicron?
Mar 4, 2021 • 6 tweets • 4 min read
Our new study is now out @JExpMed showing that asymptomatic infection induces a strong and balanced #Tcell response: Key to controlling #SARSCoV2 infection without getting #COVID19? bit.ly/3014aNv
Big thank you to everyone involved! Our collaborators @nus_sling followed asymptomatic men living in a SARS-CoV-2 affected dormitory longitudinally. Serology testing allowed us @dukenus and @mysgh to define their time of infection.
Nov 28, 2020 • 5 tweets • 3 min read
Our new pre-print is out @biorxiv_immuno! We studied #SARSCoV2 specific #Tcells in asymptomatic infection. Two important messages: Within the first month after infection, the magnitude and pattern of the SARS-CoV-2 specific T cell response was similar to COVID-19 patients; however, their frequency seems to decrease slightly faster. Image
Jul 15, 2020 • 5 tweets • 5 min read
Our paper about #SARSCoV2-specific #tcell immunity in cases of #COVID19 and #SARS, and uninfected controls is now out, peer-reviewed and published in @nature! nature.com/articles/s4158…

3 take-home messages:
(1/5) 1) Infection with #SARSCoV2 induces virus-specific T cells

2) Patients recovered from #SARS 17 years ago still possess virus-specific memory T cells displaying cross-reactivity to #SARSCoV2
(2/5)