Very happy to see announcement to re-open elementary schools in NYC. When preventative measures are in place, transmission in schools has been low. Unfortunately only subset of children will be able to return (minorities lose again).
Thread @elizashapiro
nytimes.com/2020/11/29/nyr…
The importance of in-person school for young children's learning has been a recurring them of the pandemic. It was beautifully laid out in article by @meiralevinson @mugecevik @mlipsitch
nejm.org/doi/full/10.10…
A key question early in pandemic was whether schools would be hotspots for transmission of SARS-CoV-2, as they are for influenza. Early papers suggested children were much less likely to be infected, but these studies had flawed methodology.
Subsequent data showed mixed results w/ children often having lower infection but sometimes showing similar exposure. But few studies were done when schools were open so questions remained how schools would impact transmission.
Substantial transmission was documented in several schools (mostly high schools) that were open without preventative measures, leading to fears by parents & teachers that in-person schools would put them at risk.
npr.org/sections/coron…
However, infection in primary schools & schools with preventative measures in place has been remarkably lower leading to calls from many that schools should be kept open.
nytimes.com/2020/10/19/nyr…
Thus it's been frustrating for parents& epidemiologists to repeatedly see schools closed for in-person learning, especially when restaurants or bars are still open. I'm guessing this is b/c restaurants/bars have stronger lobbying power & teachers have often argued for closing.
Hybrid learning (a few days in-person; a few virtual) has also been a huge struggle for parents, teachers & kids. Kids sometimes mix pods b/w school & home days increasing risk. Teachers sometimes double-taught. Parents had trouble working leading to lost employment (esp. women).
So, this announcement to have in-person learning for primary schools in NYC is welcome. But it won't serve all children & will leave minorities disproportionately impacted b/c they didn't previously sign up for in-person learning & aren't allowed to opt-in now.
Article doesn't say why parents can't opt-in for their students now, but one issue faced by huge number of schools is how to keep key preventative measure - 6' distancing - in place in schools where there is no room to do so w/ full classes. Hybrid learning was 1 poor option.
Possible solutions for this issue - using unused spaces (e.g. gyms) - aren't sufficient in most schools. Outdoor tents have also been proposed in fair-weather places but aren't widely adopted (cost? space?). I haven't seen good cheap solutions for crowded schools - do they exist?
If not, $$ should be allocated to this very important issue. Maybe schools will get help from Biden-Harris?

In meantime, it's not clear what will happen to young kids who didn't sign up for in-person classes in earlier & can't switch now. @elizashapiro - any info?
Will classes be taught remotely & in-person simultaneously? This is tough for teachers & students but any other approach requires double teaching. I haven't seen good solutions for this either. Please suggest some if they exist.
One possibility I haven't seen proposed & haven't seen data on is whether masks & ventilation might be enough to keep transmission low w/out increased distancing. This would get around classroom capacity issue. Is there data to support this as being sufficient? @apsmunro
Otherwise, a return to in-person learning cannot benefit all kids & will widen gap between kids in learning. This is not a solution we should accept.

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More from @DiseaseEcology

1 Dec
Why haven't data been released from vaccine trials on viral loads to assess reduced infectiousness? Since trials include testing cases for SARS-CoV-2, wouldn't all have 1+ sample from each case? N=185(Vac),11(Plac) (Moderna);162(V),8(P) (Pfizer/BioNtech)?
@nataliexdean @mlipsitch
These aren't huge sample sizes for the vaccinated group, but I'm betting there have been more cases in both groups since these results were reported & big effects could be detected even with smallish sample sizes. Given importance of reducing transmission this is big Q.
More explanation: we still have no data on whether Pfizer/Moderna vaccines reduce infection/infectiousness. All we know is it reduces chance of symptomatic infection. If they don't reduce infectiousness, then they don't protect pop around vaccinated person.
Read 5 tweets
27 Nov
This tool to calculate risk of becoming infected w/ COVID19 is being promoted by some loud (& not well informed) folks. It gives ridiculously precise probabilities & data simply do not exist to quantify things this precisely.
Short thread
zeit.de/wissen/gesundh…
Tool allows you to adjust 1 or more: size of room, duration, # people, ventilation (4 levels!), masks (3 kinds!), speaking duration&volume. Online tool then gives prob of becoming infected & # infected through aerosols w/ precision (e.g. 21%, 2 people infected).
It then gives examples of risk calculation for 5 settings (classroom, restaurant, choir, office, living room). 4 shown here.
Read 9 tweets
3 Nov
Interesting new preprint trying to assess surface transmission of COVID-19/SARS-CoV-2.

tl;dr RNA is everywhere but in very low amounts; surface sampling could be useful for surveillance. Risk of infection unknown b/c study didn't look at live/infectious virus.
Short thread
Background
One of the huge early questions about transmission of SARS-CoV-2 was if the virus could be easily transmitted on surfaces. We all heard 1000s of times how much we should wash our hands, in part, to protect us against surface transmission. But...
Epidemiological evidence rarely suggested surface transmission was major issue. The best evidence for the absence of its importance (which is a hard thing to study!) was that (nearly?) all early cases in some locations (e.g. Singapore) could be traced back to known close contact.
Read 14 tweets
31 Oct
New paper showing very high household transmission of COVID-19 in US. I haven't seen detailed summary, so here's one. There's a ton here to think about. Kids, culture, COVID.
Thread.
cdc.gov/mmwr/volumes/6…
Background
Transmission of SARS-CoV-2 occurs primarily through sustained close contact. Certainly there are rarer more distant spreading events, but study after study shows that close contacts have an order of magnitude higher chances of becoming infected.
In case you want refs for this very well supported claim, here's a couple (& some data):
wwwnc.cdc.gov/eid/article/26…
thelancet.com/action/showPdf…
Read 24 tweets
29 Oct
How many SARS-CoV-2 infections are there per COVID-19 case now?
Early estimates & guesses suggested there were 10 infections for every case, but these estimates were done when testing capacity was very low. With higher testing capacity & better engagement where are we now?
Thread
Background
It's well known that confirmed COVID-19 cases are only a fraction of all infections. Infections can be missed because people are asymptomatic, have mild enough symptoms that they don't get tested, or can't get tested even if they want to due to accessibility.
In Mar-Apr underascertainment of infections was so large & uncertain it led to claims that there may have been hundreds of infections per confirmed case. A famous example is paper suggesting 1/2 of UK MAY have been infected by Mar
ft.com/content/5ff646… medrxiv.org/content/10.110…
Read 23 tweets
26 Oct
Very provocative new paper by @dylanhmorris @jlloydsmith on effects of temp & humidity on survival of SARS-CoV-2 on surfaces. Need to be careful in interpreting most novel aspects of this paper.
Thread.
Background
Effects of temperature & humidity on survival of viruses is potentially of huge importance as it can influence transmission b/w people & has been argued to be key mechanism driving flu seasonality. See perspective by @mlipsitch C Viboud pnas.org/content/106/10…
New paper suggests that viral survival on surfaces declines w/ temp & is lowest at intermediate humidity. If robust, could guide how to reduce risk of indoor transmission - warmer & 40-60% RH best. Indoor risk v important for next 4-6 mo. But... Image
Read 18 tweets

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