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Michael Griksaitis Profile picture
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2 Dec, 5 tweets, 5 min read
Hector Wong discusses the clinical application of biomarkers in #sepsis

Starts with how can biomarkers help us...

#PedsICU #WFPICCS20
A great picture showing how the aim of biomarkers is to allow precision medicine - but you need to understand the concept of enrichment first!

#PedsICU #WFPICCS20 #Sepsis
The development of AKI is independently associated with morbidity and mortality in #sepsis

Combining this with additional biomarker activity is helpful

#PedsICU #WFPICCS20
Using genomics Hector Wong’s team have demonstrated that the use of steroids in some groups of #sepsis with specific endotype phenotypes increase mortality.

Does this account for the heterogeneity we see in #steroid trials?

#PedsICU #WFPICCS20
Research is now going on (SHIPSS trial) to help try and identify if we can work out which children will benefit from steroids in #sepsis using biomarkers...

The future in #sepsis is exciting!

#PedsICU #WFPICCS20

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More from @MJGriksaitis

Michael Griksaitis Profile picture
2 Dec
Sharon Y Irving on ‘early enteral #nutrition: timing is more important than initial volume’

Starting with what is early enteral nutrition... definitions are vague 👇 but generally within 24hrs is recommended

#PedsICU #WFPICCS20 Image
Need to consider the metabolic response of critical illness on #nutrition - this is multi factorial

But it’s key to remember that this response is not predictable, will vary with the illness and hard to assess

#PedsICU #WFPICCS20 Image
The blood flow to the splanchnic & GI tract circulation can be varied during resuscitation and critical illness - all this can lead to impact to the ability to tolerate enteral #nutrition

#PedsICU #WFPICCS20 ImageImage
Read 6 tweets
Michael Griksaitis Profile picture
2 Dec
Suchitra Ranjit discusses multimodal monitoring during #sepsis to help decode the physiological diagnosis and personalise therapy

Opening message is that cardiac output is difficult to assess at the bedside

#PedsICU #WFPICCS20
MAP is often used as a proxy of CO - is this reasonable?

There is not a strong relationship between them in post-cardiac surgical children

#PedsICU #WFPICCS20 Image
What happens when fluid is given in #sepsis?

Again: v weak correlation between CI & MAP

Interestingly almost 50% of patients did not respond to fluid & significant % of patients had a fall in BO/CI!

48% of children needed more inotrope after the fluid

#PedsICU #WFPICCS20 ImageImageImageImage
Read 5 tweets
Michael Griksaitis Profile picture
2 Dec
Joe Carcillo discusses clinical phenotypes & outcomes of #sepsis

He says mortality was reduced in the emergency department by protocols using early antibiotics/fluids

Yet some children who end up on #PedsICU develop multiorgan failure despite following protocols

#WFPICCS20
Four clinical phenotypes have been associated with progressive multiorgan failure in #sepsis

All of these phenotypes end with macrophage activation syndrome.

Research is going on to target therapies against each phenotype (eg, TAMOF with plasma exchange)

#PedsICU #WFPICCS20
Children can have one or more of these phenotypes and some are more common than others.

This data is important when planning #research trials for targeted #sepsis therapies

But also this data has implications for clinical outcomes...

#PedsICU #WFPICCS20
Read 5 tweets
Michael Griksaitis Profile picture
2 Dec
Steven E. Wolf now talks about #PedsICU #airway #burns

Airway burns is something I always worry about. Looking forward to his insights in this topic

#WFPICCS20 #PedsAnes
Airway probs can occur from:
- direct burns
- inhalation injury (10-20% of all burns pts)
- trauma from other injuries
- 3rd spacing oedema during fluid resuscitation
- long term intubation (eg subglottic stenosis)

#PedsICU #PedsAnes #WFPICCS20
Don’t forget carbon monoxide poisoning in airway burns!

#PedsICU #PedsAnes #WFPICCS20
Read 5 tweets
Michael Griksaitis Profile picture
2 Dec
Prof. Bettina Vom Dessauer now talks about the #burns patient as a critically ill patient with systemic problems.

#PedsICU #WFPICCS20
Outcomes in #burns patient associated with:
- early admission to hospital
- care in a specialised burns unit
- control of infections
- early nutrition

These children are often healthy before the injury and this results in the whole homeostasis being altered

#PedsICU #WFPICCS20
The pathophysiology of #burns patients is multi systemic and occur at a cellular level

What we see clinically is distributive shock.

#PedsICU #WFPICCS20 #physiology
Read 7 tweets
Michael Griksaitis Profile picture
2 Dec
Catching up on #burns patients on the #PedsICU - first up Steven E. Wolf discussing specialised burns care by the surgical team

He starts by discussing the ultimate goals of paediatric burn care:
- no deaths
- no scars
- no pain

We are improving but not there yet

#WFPICCS20
‘Burns are as bad as they are going to get at the start; they can only get better - burns are different to chronic diseases’ - Steven E. Wolf, burns surgeon/Intensivist

#PedsICU #WFPICCS20
What are the strategies for management of the #burn wound?

The key is fix and heal the wound. Then de-intensify the patient as soon as possible.

Remember: #burns wounds will have organisms cultured - but are they causing infection?

#PedsICU #WFPICCS
Read 8 tweets

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