Discover and read the best of Twitter Threads about #physiology

Most recents (8)

𝙄𝙛 𝙮𝙤𝙪𝙧 𝘽𝙤𝙙𝙮 𝙎𝙮𝙨𝙩𝙚𝙢𝙨 𝙝𝙖𝙙 𝘽𝙧𝙖𝙣𝙙 𝘼𝙢𝙗𝙖𝙨𝙨𝙖𝙙𝙤𝙧𝙨 (INDIAN VERSION)
(A Thread)

#MedTwitter #MBBS #physiology
GIT ( Digestive System)
Nervous System
Read 9 tweets
The promised #Tweetorial on validation of #COVIDー19 phenotypes that we published @AnnalsATS

But before we start.

Disclosures:
- I'm a splitter and 💕 phenotypes
- If physiology can teach us; I'm all for it!
- But, data and physiology should converge

What we know:
- #ARDS can be split into #phenotypes
- But, uncertain therapeutic implications



- #COVID-19 might be split into phenotypes as well
- But, ☝️based on #physiology with little data to back it up.
Remember:
- H phenotype = ⬆️elastance (=⬇️compliance) + ⬆️ lung weight + ⬆️shunt + ⬆️recruitability. What we consider ARDS.
- L phenotype is opposite - not resembling most ARDS cases.. Would not benefit ⬆️PEEP, ⬆️TV?

Lung morphology is explained here:
Read 9 tweets
Prone positioning is not an airway clearance technique. It is used to correct ventilation to perfusion matching which is impaired in acute respiratory distress syndrome (ARDS).

Thread. #physiology #COVID2019 #cvpPT
Acute respiratory distress syndrome (ARDS) due to a viral infection (ex. COVID) is not an “airway clearance” problem. It’s a ventilation to perfusion problem due to changes in the epithelial layers of the type 1 alveolar cells and pulmonary capillary.
Normally those epithelial layers create a barrier that only permits at most a trace amount of fluid into the alveoli and the space between the layers. The space between the two layers is incredibly small, it is about 1 cell thick.
Read 15 tweets
We all learn in medical school to give calcium in hyperkalemia for ‘membrane stabilization’. But what does ‘membrane stabilization’ actually mean? 🤷‍♀️ #iforgot #medschool #nephtwitter #tweetorial #physiology #pleasecareeventhoughstep1ispassfail
2/
Trick question - because there are 2 answers! But before we tackle hyperkalemia, check out this brief but brilliant refresher on action potentials in the heart.
3/
Now, hyperkalemia raises the resting membrane potential of cardiac myocytes, shifting them closer to the threshold for activation.

This should make the myocytes more irritable and easily activated - which it does... at first!
Read 17 tweets
DOI: doi.org/10.1016/j.ijca…

Drs @SukhNijjer, @jerd10 and @RicardoPetraco. What are your views on @DavidLBrownMD fallacies of FFR?

As a budding interventional cardiologist, I like to hear all opinions and sides to the story :)
“In conclusion, FFR in isolation is of no proven clinical value in the evaluation of patients with suspected ischemia. The ESC guidelines continue to promote an outdated paradigm for the evaluation of suspected ischemia that focuses on the focal epicardial stenosis.”
The 4 fallacies

1/4 - The first fallacy is the foundational premise of FFR that ischemia caused by a focal obstructive epicardial coronary stenosis is on the direct pathway to death or MI and therefore should be a target of revascularization
Read 7 tweets
Another day on service and you are starting with answering a page from PACU. "Hi this is nephrology fellow returning your page". "Great! This is Ortho, and our patient post op has low potassium here; I believe you call it HYPOkalemia" #Loveourorthopods #Tweetorial #medthread
Join us for our electrolyte abnormality du jour and learn how to break it down! #nephtwitter #medtwitter #FOAMED See our full post @RenalFellowNtwk > renalfellow.org/2019/11/14/the…
59 yo F with a hx of HTN, and HLP admitted for a left femur fracture; she was found down by her neighbor 3 days after her fall; awake and in pain. Now, patient is post op; and on labs: (baseline cr: 0.51). UA unremarkable.
Read 19 tweets
Dear twitter,

After a loooong 2wks of conferencing at #SfAA2019 & #AAPA2019, & after a couple of speedbumps, I'm finally back home in Oregon & I have time to do something I've been trying to do since #AmAnth2018--

My ~Twitter Grant Proposal~! (Cue echo effect)

#DeStressMyDiss
I came up w/the idea of proposing my research to twitter last fall while attempting force my proposal to fit the requirements of a theory-heavy grant opportunity.

I often have to re-write what I *really* mean to account for the views/feels of my "peers" who "peer-review" my app.
But the thing is, they aren't my "peers," bc #Indigenous academics like me haven't been welcome in #Bioanth long enough for funding agencies to actually have enough of my peers available to peer-review.

So my work must be squished & squeezed to get Western scientists to like it.
Read 19 tweets
After long overdue, I am hopping on the #tweetorial bandwagon @tony_breu @AdamRodmanMD. So here goes nothing! #FOAMed #MedEd #Physiology
I’ve often been told not to order an ESR because it is a nonspecific test. In fact, our hospital doesn’t even run it anymore, it's a send-out!

So, what are the factors that influence ESR to make it non-specific?

(written alongside @AndyHale33 @FreedoBaggins)
In 1897, Polish pathologist Edmund Biernacki noticed that buckets of blood separated into the red blood cell (RBC) and plasma components at different rates in different disease states.

ncbi.nlm.nih.gov/pubmed/?term=K…
Read 23 tweets

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