The US is reporting over 2000 deaths per day from Dec 1 and I believe will do so consistently throughout December based on daily case loads above 120k starting early November. 1/4
A drop in reporting over Thanksgiving weekend has made for some difficulty in directly comparing 7-day averaged deaths, but the trend is clear. Red bars are daily reported deaths from @COVID19Tracking and black line is 7-day sliding average. 2/4
The simple projection of 1.7% of reported cases into deaths 22 days later has remained largely accurate, although drop of reporting during Thanksgiving weekend is quite clear. We'll know soon whether 7-day average returns back to projection. 3/4
Today's 210k cases is a new record. If trend continues as it has, it's likely that ~3500 of these individuals will succumb to their disease and these deaths reported later in the month. 4/4
The authors do a careful serological investigation, but it necessarily suffers from testing a large number of samples with an assay that is not perfectly specific. 2/10
The ELISA used by the authors has a stated specificity of 99.3% and the authors tested 519 "true negative" blood samples collected from 2016 to 2019 from healthy adults and suspected hanta virus patients and observed 3 false positives (0.6%) matching this specificity. 3/10
Another update on #COVID19 circulation in the US. With today's report we're seeing an average of ~172k daily cases reported compared to ~157k a week ago, and we're seeing ~1650 daily deaths reported compared to ~1200 a week ago. 1/10
Although this is still a staggering amount of cases and growing daily, the rate of growth at the US level appears to be (at least temporarily) slowing. Here, I've plotted data from @COVID19Tracking, showing daily cases in the US on a log scale alongside 7-day moving average. 2/10
Throughout October we saw steady exponential growth of the US epidemic (indicated by linear-on-a-log-scale dynamics and shown in the graph as the dashed straight line). Early November outpaced this steady growth but has recently slowed. 3/10
When I ran these simple lagged case fatality rate (CFR) calculations last week I was surprised and troubled at how big the predicted numbers of deaths in the coming weeks were. Since then #COVID19 daily case counts have continued to rise. 1/10
@alexismadrigal and @whet describe in much better detail the simple logic behind this calculation here: theatlantic.com/science/archiv… and they do a thorough job investigating assumptions of the method. 2/10
Ryan Tibshirani with the Carnegie Mellon Delphi Research Group very helpfully did an independent replication of the method here: htmlpreview.github.io/?https://githu…. 3/10
One small note about these trials. It's often assumed that vaccines are only a proxy for immune response to natural infection. However, there's nothing that prevents vaccines from inducing better, more durable protection than natural infection. 3/8
The #COVID19 epidemic is rapidly growing throughout the US. What happens now? Here I try to make some predictions, but mostly try to explain how I think about the epidemic. 1/14
The US just reported ~170,000 cases in a day. However, there hasn't been a sudden increase in transmission. This is the same exponential growth process going on for weeks now. Rt has ticked up from a US average of ~1 in August to ~1.15. Data from rt.live. 2/14
This increase in Rt can be ascribed to seasonality of the virus. Seasonality of respiratory pathogens is (incredibly) not well understood but is thought to be due to a combination of indoor crowding and increased stability of viral particles in drier winter air. 3/14
A brief update on our work with the sequencing of the White House #COVID19 outbreak. Since posting on Nov 1, groups from all over the US have shared an additional 2798 #SARSCOV2 viral genomes via @gisaid and additional connections have emerged. 1/9
This sequencing has revealed additional viruses circulating in Virginia and collected between Aug and Oct that fall alongside the WH lineage, as well as three viruses from Michigan collected in Oct that are closely related to sequences from the White House outbreak. 2/9
These three viruses from Michigan possess 1 differentiating mutation and the two White House-associated viruses also possess 1 differentiating mutation. A molecular clock analysis places their common ancestor in Aug or Sep. Interactive figure at nextstrain.org/community/blab…. 3/9