2/ Individuals receiving anticoagulant therapy or those with a bleeding disorder that would contraindicate intramuscular injection, should not be given the vaccine unless the potential benefit clearly outweighs the risk of administration.
3/ Immunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to the vaccine. No data are available about concomitant use of immunosuppressants.
4/ There is no or limited amount of data from the use of COVID-19 mRNA Vaccine BNT162b2 in persons that have previously received a full or partial vaccine series with another COVID-19 vaccine.
5/ There is no data available on the interchangeability of COVID-19 mRNA Vaccine BNT162b2 with other COVID-19 vaccines to complete the vaccination series.
Animal reproductive toxicity studies have not been completed. COVID-19 mRNA
6/ Vaccine BNT162b2 is not recommended during pregnancy.
For women of childbearing age, pregnancy should be excluded before vaccination.
In addition, women of childbearing age should be advised to avoid pregnancy for at least 2 months after their second dose.
7/ COVID-19 mRNA Vaccine BNT162b2 should not be used during breast-feeding.
It is unknown whether COVID-19 mRNA Vaccine BNT162b2 has an impact on fertility.
8/ There were no meaningful clinical differences in overall vaccine efficacy in participants who were at risk of severe COVID-19 disease including those with one or more comorbidities that increase the risk of severe COVID-19 disease (eg asthma, BMI ≥ 30 kg / m2, COPD, diabetes)
9/ Confirmed cases were determined by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and at least 1 symptom consistent with COVID-19 disease.
10/ Case definition (at least 1 of): fever, new or increased cough, new or increased shortness of breath; chills, new or increased muscle pain, new loss of taste or smell, sore throat, diarrhea or vomiting.
AAR 0.84
NNT 119
The vaccine prevents 1 mild case in 119 vaccinated. Therefore, 118 vaccinated suffer the possible adverse effects without any benefit.
12/ There is no data on the effect on the transmission of the disease.
Apparently 7,379 patients were "lost" (efficacy data are given for 36,621 out of 44,000)
Safety data are given for only 19,067 patients (not 36,621)
and 13/
Healthy individuals over 12 years old were included, but the results are only given in those over 16 years old.
There is no efficacy data in the prevention of serious disease (hospitalizations, ICU admission) or mortality #vaccine#covid19@pfizer assets.publishing.service.gov.uk/government/upl…
1/ Información profesionales sanitarios. #vacuna#covid19@Pfizer BioNTech
REG 174 INFORMATION FOR UK HEALTHCARE PROFESSIONALS assets.publishing.service.gov.uk/government/upl…
RESUMEN
Aún no se ha establecido la seguridad y eficacia de la vacuna de ARNm de COVID-19 BNT162b2 en niños menores de 16 años.
2/ Las personas que reciben terapia anticoagulante o aquellas con un trastorno hemorrágico que contraindicaría la inyección intramuscular no deben recibir la vacuna a menos que el beneficio potencial supere claramente el riesgo de administración.
3/ Las personas inmunodeprimidas, incluidas las personas que reciben terapia inmunosupresora, pueden tener una respuesta inmunitaria disminuida a la vacuna.
No se dispone de datos sobre el uso concomitante de inmunosupresores.
#covid19#vaccine@pfizer
Number Needed to Treat: 279 (to avoid an infection, not a death, neither a severe case).
NNT Número de Pacientes a Tratar 279 (para evitar una infección, no una muerte, ni un caso grave).
NNH Number Needed to Harm: Unknown
#covid19#vacuna#vaccine
Riesgo relativo: 90% Relative risk: 90%
Riesgo absoluto: 0,35% Absolute risk: 0,35%
Respecto a tener la enfermedad, no a evitar complicaciones ni muertes. In preventing the disease, not deaths, neither complications.
- How well does the vaccine prevent severe disease? ¿Impacto en prevención de enfermedad grave? NOT KNOWN
- How well does the vaccine prevent infection? ¿Impacto en prevención de la enfermedad? 0,35%
1/ "Non sensus consensus"
P Skrabanek
Lancet. 1990 Jun 16;335(8703):1446-7. doi: 10.1016/0140-6736(90)91460-r 2/ Better population immunity than herd immunity 3/ If population immunity isn't possible, a vaccine "solution" is possible? 4/ Sensus fidelium
"Las estrategias de salud pública que confían en la inmunidad de grupo para combatir la pandemia de Covid-19 son una "falacia peligrosa", alerta un grupo de 80 científicos internacionales en @TheLancet . diariodemallorca.es/vida-y-estilo/…
“Scientific consensus on the #COVID19 pandemic: we need to act now”
Conflict of interests:
Es falso lo de "Este año, debido a la convivencia de la #gripe con la #COVID19 es más importante que nunca que los grupos de riesgo y las personas con las que conviven se vacunen contra la gripe". La vacuna de la gripe no crea inmunidad de grupo, no protege a otros, ni a nadie.