This week I thought I would share some terminology that you may or may not know!

#SubfieldWednesday (1/n)
Most of our followers probably already know how that the name "hippocampus" means "seahorse" in Greek.

#SubfieldWednesday (2/n) https://www.wbur.org/npr/505754756/the-seahorse-in-your-brai
What do you think? When it's dissected like this, I can definitely see the similarity!

#SubfieldWednesday (3/n) Hippocampus removed from the brain (left), in comparison to
What about the name, "subiculum"?

Well, it comes from the Latin word for "support." Duverony also calls it the "bed" of the hippocampus.

I guess this makes sense, when viewed coronally, the subiculum "supports" the DG and CA subfields.

#SubfieldWednesday (4/n) coronal image of human hippocampus, parvalbumin stained, fro
Some of you may wonder if there is a difference between the "fascia dentata" (labeled FD below) and the "dentate gyrus" (labeled DG below). They are two different names for the same structure!

#SubfieldWednesday (5/n) The same slice of the hippocampal body labeled by three diff
What about the "uncus"? That gets it's name from the Latin word for "hook". See the images below to visualize the hook shape.

#SubfieldWednesday (5/n) Figure 1 from Zeidman & Magure, 2016: a | A schematic showinFrom Figure 1 of Ding & Van Hoesen, 2015: Medial view of the
Some of the cornu ammonis (CA) subfields have special names. Sometimes CA1 is called the "Sommer sector", CA3 is called the "Spielmeyer sector", and CA4 is called the "Bratz sector"

#SubfieldWednesday (6/n)
Let's finish off this thread with a quiz! I think this one will be easier than the last.

Which subfield is called the "vulnerable sector" and which one is called the "resistant sector" ?

#SubfieldWednesday (end)

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More from @hipposubfields

25 Nov
Hello and happy #SubfieldWednesday! Today we are going to get a bit more familiar with how the hippocampal subfields differ in their composition of different cell types, cell sizes, and layer thickness. 🍤🔬

#SubfieldWednesday (1/n)
Here are some images taken from five different hippocampal subfields (CA1, CA2, CA3, dentate gyrus, and subiculum). Can you tell which number corresponds to which subfield? 🤔

#SubfieldWednesday (2/n) Five different screenshots of histology slices of five diffe
Because a Nissl stain was applied to these slices, the cell bodies appear dark purple. This allows neuroanatomists to characterize the size, shape, and relative spacing of the cells.

#SubfieldWednesday (3/n)
Read 12 tweets
11 Nov
Happy #SubfieldWednesday! After a two-week hiatus we are returning to our quiz about the mysterious transentorhinal cortex!

This quiz even stumped some of us at @hipposubfields headquarters! We had to contact a neuroanatomist to confirm which answer is correct! (or at least "the most correct")
Braak and Braak (1985) originally described the transentorhinal cortex as a 'transition region between entorhinal cortex and temporal isocortex. This rules out answer A (part of ERC) Figure 3. from Braak H, Bra...
Read 11 tweets
21 Oct
Last week we received over 100 (!) responses on our quiz about which hippocampal subfield accumulates tau pathology earliest in the disease.

#SubfieldWednesday (1/n)
This week we will explain that the correct answer for Alzheimer's disease (but not all types of dementia) is CA1!

#SubfieldWednesday (2/n)
Work from Braak & Braak (1991) showed that CA1 develops tau pathology before the other subfields.

#SubfieldWednesday (3/n) Cartoon drawing of the medi...
Read 9 tweets
8 Oct
Hello subfield-fans! Last week's #SubfieldWednesday topic was the layered composition of the hippocampal subfields. We learned that the subfields contain three major cellular layers which makes them a part of the allocortex.

#SubfieldWednesday (1/n) Table 1 from: Insausti, Ric...
@thomcat992 replied that the hippocampus is archicortex, which is also correct! Archicortex is a type of allocortex.

#SubfieldWednesday (2/n)
Now what about the entorhinal cortex (ERC)? The ERC has six layers, so does that make it neocortex (also known as the isocortex)?

#SubfieldWednesday (3/n)
Read 12 tweets
1 Oct
Better late than never! (It's still Wednesday in some timezones!) This week's #SubfieldWednesday will be a bit briefer than normal.

#SubfieldWednesday (1/n)
Some of you might have been surprised last week when we described the hippocampal subfields as layered structures.

#SubfieldWednesday (2/n)
Even though the hippocampus sometimes gets grouped together with subcortical structures like the thalamus and basal ganglia, the dentate gyrus, CA fields, and subiculum are all part of a special type of cortex called the allocortex!

#SubfieldWednesday (3/n)
Read 7 tweets
23 Sep
It's Wednesday...so you know what that means! It's time for #SubfieldWednesday! 🥳📢

(1/n)
Two weeks ago we posted about whether you can visualize subfields on in vivo MRI. Here is a link if you missed it!



#SubfieldWednesday (2/n)
You might recall that the hippocampus is a layered structure (just like the neocortex!) and that some of the layers have different contrast properties due to different amounts of myelination and cell densities

#SubfieldWednesday (3/n) post-mortem, ultra-high fie...Drawing of the different la...
Read 18 tweets

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