We have the FDA (VRBPAC) external view 77% affirmative vote.
Not sure what the 18% who voted no or 5% abstaining were thinking.
But expect final FDA EUA approval for the 1st vaccine for the US in a very short time. 👍👍👏👏
The "no" concerns about age 16-17 are not consistent with the protocol inclusion criteria, even though the number of participants < 18 were low.
The number of participants by age, 95 were age 16 or 17
If there is a biological reason for a difference in the immune response to a vaccine for a 16-year-old vs an 18-year-old, I’ll be interested to hear it.
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Why 2 proline (P) substitutions will go down in history.
Introducing 2P's at the beginning of the central helix (CH) stabilized the spike protein's confirmation upon entering cells.
From the Jan 10 #SARSCoV2 sequence, this 2P Δ was incorporated into the mRNA vaccine designs /1
The United States has an ambitious plan to get to population level immunity, but it doesn't have the vaccines to accomplish it (no less the buy in of Americans)
@WSJgraphic by @ErikBrynildsen@joshulick@TaylorUmlauf @toddlindeman /1
Before the vaccine problems with Sanofi-GSK (wrong dose) and Astra Zeneca/Oxford (? dose) the US was already short in covering its population nature.com/articles/d4158… /2
It's the 3rd hump—its apex and duration yet unknown—that is breaking the backs of America's health workforce along with the nightmarish number of new infections and fatalities recorded each day.
adapted from @COVID19Tracking data