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Eric Topol Profile picture
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14 Dec, 4 tweets, 1 min read
1 down, 200+ million to go
Why 200+ million (not 300), and how we could get there faster
The functionality of the health system CEO in this photo is striking 😉
Too bad he is getting cropped out in newspapers

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More from @EricTopol

Eric Topol Profile picture
13 Dec
Why 2 proline (P) substitutions will go down in history.
Introducing 2P's at the beginning of the central helix (CH) stabilized the spike protein's confirmation upon entering cells.
From the Jan 10 #SARSCoV2 sequence, this 2P Δ was incorporated into the mRNA vaccine designs /1
This was a result of elegant #3D structural biology work @NIH (Barney Graham), @scrippsresearch (Andrew Ward) and collaborators from a @PNASNews paper that was rejected 5 times! pnas.org/content/114/35… /2
Without the 2P design, the mRNA vaccines would have failed.
The remarkable story is told well by @Carolynyjohnson
washingtonpost.com/health/2020/12… /3
Read 7 tweets
Eric Topol Profile picture
12 Dec
The United States has an ambitious plan to get to population level immunity, but it doesn't have the vaccines to accomplish it (no less the buy in of Americans)
@WSJgraphic by @ErikBrynildsen @joshulick @TaylorUmlauf
@toddlindeman /1
Before the vaccine problems with Sanofi-GSK (wrong dose) and Astra Zeneca/Oxford (? dose) the US was already short in covering its population
nature.com/articles/d4158… /2
Here the US ranks #32 as compared with other countries
bloomberg.com/news/articles/… @bloomberg @ArmstrongDrew @tsrandall /3
Read 11 tweets
Eric Topol Profile picture
10 Dec
We have the FDA (VRBPAC) external view 77% affirmative vote.
Not sure what the 18% who voted no or 5% abstaining were thinking.
But expect final FDA EUA approval for the 1st vaccine for the US in a very short time. 👍👍👏👏
The "no" concerns about age 16-17 are not consistent with the protocol inclusion criteria, even though the number of participants < 18 were low.
The number of participants by age, 95 were age 16 or 17
Read 4 tweets
Eric Topol Profile picture
6 Dec
Key science behind the success of the mRNA #SARSCoV2 vaccines
—A paper that was *rejected 5 times* finally published in 2017
"Full spike plus 2P" @PNASNews
pnas.org/content/114/35… w/ @scrippsresearch
—1990 @ScienceMagazine mRNA in vivo -> protein
science.sciencemag.org/content/247/49…
Important backstory of the basic science over many years that culminated in the 11 month "astonishing" success
washingtonpost.com/health/2020/12… by @Carolynyjohnson featuring @kkariko's work and @NIAIDNews Barney Graham @NIH
Meant to post the @PNAS paper (not the same one twice)
Read 4 tweets
Eric Topol Profile picture
5 Dec
10 countries, 1 outlier
That was 8; here's the 10
10 more in countries w/ >10 million population
Read 4 tweets
Eric Topol Profile picture
5 Dec
It's the 3rd hump—its apex and duration yet unknown—that is breaking the backs of America's health workforce along with the nightmarish number of new infections and fatalities recorded each day.
adapted from @COVID19Tracking data
At just over 100,000 hospitalizations, we have already past the breaking point @TheAtlantic
theatlantic.com/health/archive… @yayitsrob @alexismadrigal
We can't handle the patients now.
The ones that would be admitted.
They are getting sent home now.
New records today for cases 225,000
Hospitalizations 101, 276
and very high number of deaths 2,563
Read 5 tweets

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