📍NEW—BioNTech founder—“The vaccine contains >1270 amino acids, & only 9 of them changed—so 99% of the [spike] protein is still same”, says Şahin.
➡️He also points out #SARSCoV2 vaccine’s immune response is *polyclonal*, so antibodies & T cells attack multiple sites on protein.
➡️He also points out #SARSCoV2 vaccine’s immune response is *polyclonal*, so antibodies & T cells attack multiple sites on protein.
2) BioNTech #COVID19 vaccine is aka the Pfizer vaccine.
➡️He also adds, “scientifically it is highly likely that the immune response by this vaccine also can deal with the new virus”
➡️He predicts vaccine response studies completed in 2 weeks. 👀
➡️He also adds, “scientifically it is highly likely that the immune response by this vaccine also can deal with the new virus”
➡️He predicts vaccine response studies completed in 2 weeks. 👀
3) Latest UK 🇬🇧 #SARSCoV2 mutation updates overnight.
https://twitter.com/drericding/status/1341231738249486337
4) The new UK 🇬🇧 and South Africa 🇿🇦 mutations are worrisome though, especially their implications for convalescent plasma and monoclonal antibodies. Detailed discussion why below in this master thread 🧵 👇
https://twitter.com/DrEricDing/status/1340911632147488768
5) one mutation creates an amino acid change at 501, which lies within the critical RECEPTOR BINDING DOMAIN (ie the “docking sites” on the spike to human receptor). Look 👀 in 3D where the damn N501Y mutation is—right *inside a docking site*!
Functional mutation? Unclear yet.
Functional mutation? Unclear yet.
6) The N501Y mutation is problematic for other reasons too (see thread 🧵 branches above in #2 and #3 for more). And the 69-70 amino acid deletions also tricky—it’s near the critical N-terminal domain, and near where monoclonal antibodies (think MAB drugs like Regeneron) binds.
7) Meanwhile... look on the bright side... at least you don’t have COVID here...
https://twitter.com/drericding/status/1341359740857819136
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