💡New—VIRAL LOAD OF UK🇬🇧 b.1.1.7 VARIANT:
➡️New study by @OxfordViromics group indeed finds **higher viral load** for new variant w/ 501 mutation & 69-70 deletion.
📌How much higher? “Inferred viral loads were *3-fold higher* in people w/ new variant”.🧵
coronavirus-fraser-group.org/files/files/up…
➡️New study by @OxfordViromics group indeed finds **higher viral load** for new variant w/ 501 mutation & 69-70 deletion.
📌How much higher? “Inferred viral loads were *3-fold higher* in people w/ new variant”.🧵
coronavirus-fraser-group.org/files/files/up…
https://twitter.com/oxfordviromics/status/1341491766915198980
2) Outside Greater London, the variant has higher viral loads. Within Greater London, the new variant does not have significantly higher viral loads. But this could be due to demographics, such as a faster variant growth rate in particular age-groups.
3) So is it higher or not? Or is it some London / non-London effect? ➡️ it’s really higher.
➡️In a multivariable model (adjusting mutually), what won was the B.1.1.7 variant’s 501Y mutation as key—**higher viral load**
❌London/other region interaction effect not significant.
➡️In a multivariable model (adjusting mutually), what won was the B.1.1.7 variant’s 501Y mutation as key—**higher viral load**
❌London/other region interaction effect not significant.
4) More details on these mutations. I wrote a master explainer thread 🧵 with branching 🧵 to South Africa 🇿🇦 strain too.
https://twitter.com/drericding/status/1340911632147488768
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