Increased transmission of new UK 🇬🇧 variant among kids?

➡️Early analysis "hints a higher propensity to infect children", says Neil Ferguson of @MRC_Outbreak.

"If (proven) true, might explain significant proportion, maybe majority, of increase” #COVID19
bbc.com/news/uk-554069…
2) “Prof Wendy Barclay said the mutations to the virus appeared to be making it easier to walk through the doorways that were there.

She said this could be putting children on a "more level playing field" with adults as the virus was "less inhibited" in children.
3) “Therefore children are equally susceptible, perhaps, to this virus as adults, and therefore given their mixing patterns, you would expect to see more children being infected."

Work to understand the new variant is taking place at lightning speed—still much uncertainty.
4) “Prof Julian Hiscox, chair in infection and global health, from the University of Liverpool, told the BBC there wasn't any evidence "at the moment" that the new variant is able to infect kids more efficiently. He said this would be looked at closely by scientists over Xmas”
5) It is now thought the new variant spreads 50% to 70% faster than other forms of the virus.

R of the new virus in UK now thought to be currently 1.2... At the same time the R number was 0.8 for the other forms of the virus during lockdown and they were in decline.
6) But were kids at lower risk than adults to begin with usual common strain?

A recent study of schools found that levels of virus in school-age children reflected levels in the local community, ie that closing schools would only have a temporary effect. bbc.co.uk/news/health-55…
7) More details on the latest findings on the mutation and implications for therapy in this other thread 🧵 below 👇

8) For more technical details on the mutations in UK 🇬🇧 and South Africa 🇿🇦 , read this detailed thread 🧵
9) And the biggest vaccine question... the founder of the Pfizer/BioNTech vaccine says this... see thread 🧵 below for details. Likely it’ll be fine for the vaccine but 2 weeks to know.

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More from @DrEricDing

24 Dec
On the brink—

📌Over 2 in 5 U.S. hospitals with intensive care units have reached occupancy levels of >=85%.

📌Contrast with early Oct, just 1 in 4 that full. #COVID19

📌The 85% occupancy’ is the threshold to trigger regional stay-at-home orders.
nytimes.com/interactive/20… Image
2) “When patients get really sick with Covid, they’re in the hospital for weeks,” said Dr. Arghavan Salles, a physician who has worked in I.C.U.s in New York and Arizona over the course of the pandemic. Image
3) “When patients get really sick with Covid, they’re in the hospital for weeks,” said Dr. @arghavan_salles, a physician who has worked in I.C.U.s in New York and Arizona over the course of the pandemic. Image
Read 5 tweets
23 Dec
BIOLOGICAL SIGNIFICANCE B.1.1.7 🇬🇧 variant #SARSCoV2:

Read these 4 key circled sentences from @CovidGenomicsUK on why the mutations are worrisome.

Experts don’t think it will strongly affect vaccines, but some say maybe slightly.

See 🧵 for details. cogconsortium.uk/wp-content/upl… Image
2) This table also explains how much the variant B.1.1.7 has been seen recently. Notice how much of the total within last 28 days. Image
3) brand new details on the viral load.
Read 6 tweets
23 Dec
💡New—VIRAL LOAD OF UK🇬🇧 b.1.1.7 VARIANT:

➡️New study by @OxfordViromics group indeed finds **higher viral load** for new variant w/ 501 mutation & 69-70 deletion.

📌How much higher? “Inferred viral loads were *3-fold higher* in people w/ new variant”.🧵
coronavirus-fraser-group.org/files/files/up… Image
2) Outside Greater London, the variant has higher viral loads. Within Greater London, the new variant does not have significantly higher viral loads. But this could be due to demographics, such as a faster variant growth rate in particular age-groups. Image
3) So is it higher or not? Or is it some London / non-London effect? ➡️ it’s really higher.

➡️In a multivariable model (adjusting mutually), what won was the B.1.1.7 variant’s 501Y mutation as key—**higher viral load**

❌London/other region interaction effect not significant. Image
Read 4 tweets
23 Dec
📍Huge blow—UK had halted plans to open rapid-turnaround #COVID19 tests across England amid concerns about the accuracy. Huge blow to UK’s £100bn “Operation Moonshot” mass-testing plan, to increase daily tests from 430k to 10mil. Poor 🇬🇧 case surging too.
theguardian.com/world/2020/dec… Image
2) Experts in testing and understand immunology like @michaelmina_lab think the test is good in capturing **INFECTIOUS** virus, which is key.
3) it indeed caught the critical high viral cases
Read 10 tweets
23 Dec
Welp—Pastor who told parishioners not to fear pandemic—parents then die of COVID after Thanksgiving.

🔥“I’m not wearing a mask—There will be no social distancing CDC. Faith over fear!”

➡️A few weeks later, both parents died of #COVID19 in Fort Worth 🏥.
dallasnews.com/news/public-he… Image
2) Pastor Todd Dunn had been preaching “Faith over fear!” since the COVID-19 pandemic started. Before Thanksgiving, he posted a message on Facebook dismissing precautionary measures by CDC to keep wearing masks and avoid gatherings w/ family members who don’t live in same house. Image
2) “Dunn, who is the pastor of 2nd Mile Church in north Fort Worth where his parents were members, admitted that he was surprised by the sudden surge in COVID cases in recent weeks in Tarrant County.”

.. SURPRISED THAT EPIDEMIOLOGISTS ARE RIGHT??? 🤦🏻‍♂️
Read 6 tweets
23 Dec
NOT EVEN REMOTELY TRUE:

Donald Trump Jr. claims “red states” had fewer #COVID19 transmissions than “blue states” due to “common sense.”

2) Which of these are red states and blue states again @DonaldJTrumpJr? Are my eyes kinda bloodshot or is it the figure just red? Image
3) I swear my eyes must be bleeding red or some reason @DonaldJTrumpJr. Image
Read 5 tweets

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