We've now doubled the peak hospitalizations from the previous 2 US case surges.
And it's no wonder the death toll again today is nearly 3,500. @COVID19Tracking
Sure the virus is hard to contain, but that's especially the case when so little is being done
The @HHSgov declared covid as a public health emergency on Jan 31st
And @WhiteHouse a national emergency March 13th whitehouse.gov/presidential-a…
If that was emergency, then what is this?
The actions we could take beyond financial support that still has not been approved......
1. Distribute high quality (surgical or K/N95) masks to all households [@USPS planned 650 million distribution in April, blocked by @WhiteHouse] 2. Make mask mandates a national policy with enforcement 3. Provide free rapid home covid tests to all households for daily use
4. Set up a digital multi-layered dashboard for all Americans that includes mobility, risk zones, wastewater surveillance of all municipalities, wearable sensor support for temp, resting heart rate and other parameters to get ahead of outbreaks. The weather report for each of us.
5. Support scale-up of genomic surveillance to stay ahead of new variants (graph via @trvrb)
I'll stop here. There's a long list......
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1. Structural biology has been a standout in the pandemic, mapping the virus, antibodies and vaccines atom by atom. So I had a conversation with one of its leaders, Andrew Ward @WardLab1, my @scrippsresearch colleague soundcloud.com/prescrippsions…
2. Back in 2016, Andrew and his colleagues were the first to see and publish the coronavirus spike protein, via cryo-electron microscopy (a common cold virus, HKU1) nature.com/articles/natur…@nature
Note the team, which proved to be formidable @McLellan_Lab@KizzyPhD Barney Graham
3. In the podcast, Andrew reviews how they came together. A next act was the famous 2P (2 proline substitutions) paper that was rejected 5 times before being published @PNASNews
Subthread about that here:
The B.1.1.7 variant has 23 mutations
I spoke to Andrew Ward (@WardLab1) @ScrippsResearch today (podcast coming) about its structural biology. He thinks the N501Y (in common w/ South Africa variant) is the driver for increased transmission; he's not concerned re: vaccine efficacy
On @CNN@wolfblitzer, @NYGovCuomo just said the new variant transmits 70-fold the D614G and that it accounted for Europe’s 2nd wave. Both are wrong!
While the B.1.1.7 variant is thought to have been derived from accelerated evolution in an immunocompromised patient with covid (see examples in these 2 @NEJM reports), if the functional culprit is indeed N501Y, that might turn out to be a red herring
1. There are limited data about the vaccines for people who have had covid. But we can learn from the @Pfizer@BioNTech and @moderna trials which had 3% and 2.2% participants respectively confirmed at baseline (via FDA briefing docs)
2. In the Pfizer trial there were 9 reinfections among 670 participants (1.3%) who received placebo which was the same rate as those without prior infection (259 of 19,818 participants, 1.3%).
Only 1 reinfection in the vaccine group (after ≥ 7 days) for those w/ prior infection
3. We need to learn more about this with so many people with prior infections getting vaccinated. But this finding suggests vaccine-induced immune response may add protection to the natural response and adds another layer to the superhuman concept 👇