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Eric Topol Profile picture
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17 Dec, 5 tweets, 4 min read
You have one guess for what is @ScienceMagazine's Breakthrough of the Year, 2020 😉
The new issue is full of insightful, useful content on the pandemic
This "Year like No Other" timeline is the best I've seen so far
@ScienceVisuals
science.sciencemag.org/content/370/65…
science.sciencemag.org/content/370/65…
Vaccines. The hope. @sciencecohen reviews the vaccine landscape, the 95% efficacy in context, and gets personal about his mother
The Divisiveness. @kakape reviews the forces that took our response off track, the politicization, anti-science.
Starts off w/ @angie_rasmussen, one of my favorite virologists (podcast coming soon), and her memorable response to Scott Atlas, who played a major role in US response
The upbeat editorial by @hholdenthorp on the monumental achievement of such high efficacy and safe vaccines, so incredibly fast.
"This breakthrough is a triumph for all of science."

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More from @EricTopol

Eric Topol Profile picture
18 Dec
1. There are limited data about the vaccines for people who have had covid. But we can learn from the @pfizer @biontech and @Moderna trials which had 3% and 2.2% participants respectively confirmed at baseline (via FDA briefing docs)
2. In the Pfizer trial there were 9 reinfections among 670 participants (1.3%) who received placebo which was the same rate as those without prior infection (259 of 19,818 participants, 1.3%).
Only 1 reinfection in the vaccine group (after ≥ 7 days) for those w/ prior infection
3. We need to learn more about this with so many people with prior infections getting vaccinated. But this finding suggests vaccine-induced immune response may add protection to the natural response and adds another layer to the superhuman concept 👇
Read 4 tweets
Eric Topol Profile picture
18 Dec
How do you get to over 240,000 covid cases in one day?
Ask the USA.
An unabated virus.
A rudderless country.
Today @COVID19Tracking
With more than 114,000 Americans hospitalized Image
Our status in San Diego and LA.
Hope yours is better
Image
Read 4 tweets
Eric Topol Profile picture
14 Dec
1 down, 200+ million to go
Why 200+ million (not 300), and how we could get there faster
The functionality of the health system CEO in this photo is striking 😉
Read 4 tweets
Eric Topol Profile picture
13 Dec
Why 2 proline (P) substitutions will go down in history.
Introducing 2P's at the beginning of the central helix (CH) stabilized the spike protein's confirmation upon entering cells.
From the Jan 10 #SARSCoV2 sequence, this 2P Δ was incorporated into the mRNA vaccine designs /1
This was a result of elegant #3D structural biology work @NIH (Barney Graham), @scrippsresearch (Andrew Ward) and collaborators from a @PNASNews paper that was rejected 5 times! pnas.org/content/114/35… /2
Without the 2P design, the mRNA vaccines would have failed.
The remarkable story is told well by @Carolynyjohnson
washingtonpost.com/health/2020/12… /3
Read 7 tweets
Eric Topol Profile picture
12 Dec
The United States has an ambitious plan to get to population level immunity, but it doesn't have the vaccines to accomplish it (no less the buy in of Americans)
@WSJgraphic by @ErikBrynildsen @joshulick @TaylorUmlauf
@toddlindeman /1
Before the vaccine problems with Sanofi-GSK (wrong dose) and Astra Zeneca/Oxford (? dose) the US was already short in covering its population
nature.com/articles/d4158… /2
Here the US ranks #32 as compared with other countries
bloomberg.com/news/articles/… @bloomberg @ArmstrongDrew @tsrandall /3
Read 11 tweets
Eric Topol Profile picture
10 Dec
We have the FDA (VRBPAC) external view 77% affirmative vote.
Not sure what the 18% who voted no or 5% abstaining were thinking.
But expect final FDA EUA approval for the 1st vaccine for the US in a very short time. 👍👍👏👏
The "no" concerns about age 16-17 are not consistent with the protocol inclusion criteria, even though the number of participants < 18 were low.
The number of participants by age, 95 were age 16 or 17
Read 4 tweets

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