2) gene sequencing for finding the mutated virus is much slower and more expensive. But we need to test likely hundreds of thousands or millions to track down the new B117 variant. UK 🇬🇧 stumbled upon a short cut when it realized a special PCR can find mutated signal!
3) This special shortcut PCR test is called the Taqpath- and made by @thermofisher. They refuse to release the primer probe sequence to this shortcut test that can quickly find the 69-70 deletion of new B117 variant with the “S gene dropout” signal. @JoeBiden should invoke DPA.
4) Using Defense Production Act would force the formula of this TaqPath test from @thermofisher. But that is still weeks away.
We actually only discovered the Colorado B117 variant case because of this “S gene dropout” PCR test.
Hence lives being endangered by its withholding.
5) How easy is it? The genetic sequence code can literally fit inside one line of a tweet: @K_G_Andersen thinks it’s this genetic sequence fragment code for the primer probe. But @thermofisher won’t confirm or share this **literally one line** of code!
TGGAAAAGAAAGGTAAGAACAAGTCC
6) If we had the sequence, we can do dense mapping like this. But @thermofisher refuses to share for betterment of mankind. And remember they didn’t even design it for this, they found it by dumb luck accident. #thermofisherpandemicprofiteer
7) To be clear, @thermofisher did not “design” the TaqPath PCR test primers to the B117 variant. As @kakape points out, it was a “fortunate coincidence” it picked up the 69-70 deletion in the variant. Dumb luck basically. #thermofisherpandemicprofiteer
8) Tons of scientists are angry and complaining. Tons.
Fact is @thermofisher didn’t do anything novel to discover it, did not design it for variant, or optimize it for B117. They basically won a random lottery they didn’t buy a lottery ticket for. #thermofisherpandemicprofiteer
9) Good news is a Yale team has developed new PCR protocols and primer to detect the B117 variant. But he laments, “All of this would be a lot easier if @thermofisher just shared their sequences”, because Nathan doesn’t have B117 virus to test with. #thermofisherpandemicprofiteer
10) And do we have evidence @thermofisher has refused to help scientists? Oh yes, two scientists says that TF “wouldn’t tell us the target sequence of the probe” says @lea_starita, and TF “wouldn’t give us the probe sequence” says @NathanGrubaugh.
11) Ultimately, scientists will find a way and develop new PCR tests for the B117 variant. But the problem also is the time delay to validate a new test—since the TF one already has EUA. If TF shared, it would speed up worldwide detection of the more contagious variant. Shameful.
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2) “This increases the R number by between 0.4 & 0.8– current Tier 4 restrictions are unable to contain its spread, even w/ closure of schools & universities. The pandemic is now out of control, and the NHS is struggling, with some hospitals having to stop non-COVID activities.”
3) “The NHS is no longer being protected. For these reasons, there is a strong argument for maximising the coverage of the population with at least one dose of vaccine, even though this requires a change to the dosage schedule.”
BREAKING—U.S. govt is considering giving some people half-dose of Moderna's #COVID19 vaccine in order to speed vaccinations, says Moncef Slaoui, head of Operation Warp Speed, in talks w/ FDA. Bold, but maybe possible—let’s walkthrough the trial data. 🧵 reuters.com/article/us-hea…
2) "We know that for the Moderna vaccine, giving half of the dose to people between the ages of 18 and 55, two doses, half the dose, which means exactly achieving the objective of immunizing double the number of people with the doses we have," Slaoui said. #COVID19
3) “We know it induces identical immune response” to the full dose, he added.
...well, it is true that the full dose and half doses yielded roughly similar immune responses in Phase 1&2 trial/ of the vaccine. Though there are slight caveats. So let’s walk thru that data...
2) This 🇬🇧 report was done on Dec 17th, released on Dec 31, based on data before Dec 2nd. In other words, before new variant has dominated UK 🇬🇧 in Dec.
Good news is that kids are less susceptible—less likely to contract virus in the household. #COVID19 gov.uk/government/pub…
3) As for teachers, it seems positivity % is similar between teachers and other professions. This is neither good, nor bad. It just means teachers are no worse or safer as an occupation.
Airborne! OUTBREAK AT EMERGENCY DEPT—43 staffers infected at Kaiser ED in San Jose. All 43 #COVID19 positive in past week after party where one wore an air-powered costume and was asymptomatic. “Air-powered costumes will “obviously” no longer be allowed". sfchronicle.com/bayarea/articl…
2) Dr Fauci warned the #SARSCoV2 was airborne long ago in September.