1/ New guidelines from the @US_HAEA Advisory Board are now available @JACIInPractice. We provide an update on classification, diagnosis, on-demand/prophylactic tx with special considerations for women/children along with guidance on development of a comprehensive management plan.
2/#HAE can be broadly divided into #HAE due to C1INH deficiency (type 1 and type 2) and HAE with normal labs (4 mutations now identified - factor XII, plasminogen,
angiopoetin-1, and kininogen). Early diagnosis is critical. If you suspect send C4, C1INH level and function.
3/All patients with #HAE must have ready access to effective on-demand medication and trained in self-administration. Encourage on-demand treatment of all #HAE attacks. Four FDA approved on-demand treatments available (ecallantide, icatibant, pdC1INH, or rhC1INH)
4/Long-term prophylactic treatment of HAE due to C1INH deficiency should include first-line treatments (IV or SC C1INH or #lanadelumab). Oral #kallikrein inhibitor (#berotralstat) FDA approved Dec 2020! Decision on long-term prophylaxis should reflect needs of individual patient.
5/Management plans should be individualized to lessen the burden of illness and aim to provide patients with #HAE with a normal quality of life. @mghaifellows @mghallergy jaci-inpractice.org/action/showPdf…

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More from @AleenaBanerjiMD

1 Jan
1/ As #Allergists, built upon the recommendations of U.S. regulatory agencies, we can provide clear steps to the medical community on how to safely administer both doses of the #COVID vaccine in individuals with #allergic histories. #AIMedEd jaci-inpractice.org/article/S2213-…
2/ Neither the #PfizerBioNTech nor #Moderna #COVID19 mRNA vaccines are formulated with any food, drugs, or latex, but both contain the excipient #PEG. However, to date, confirmation that PEG is the cause of reactions to #CovidVaccines is lacking.
3/ Complement-activation-related pseudoallergy, vasovagal reactions (well known cause of hypotension), anxiety symptoms or vocal cord dysfunction can mimic symptoms of severe allergic reactions. Serum #tryptase, complement studies, and #PEG antibodies may be helpful.
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