Based off of Run the List Episode 24, here is a #tweetorial on💘Tachyarrhythmias💘

🎧Full episode: bit.ly/3b6svs0

Let's start with an EKG 👇 (@medicine_strong). For more practice, check out: bit.ly/35mxD7P

Thanks to @Gurleen_Kaur96 for this week's edition! Image
❓What tachyarrhythmia is shown on that EKG above❓

Keep these things in mind when interpreting:
🔶Rate
🔶Regularity
🔶Width of QRS complex
🔶Relationship of P wave to QRS complex

And continue reading this 🧵 for the correct answer...
First, let's review some 🔑 principles:

🥇Always assess if patient is hemodynamically stable!

✅Hypotension
✅Altered Mental Status
✅Chest pain
✅Shortness of breath

If unstable ➡️ cardioversion or defibrillation Image
Now an aside on terminology:

💓Tachycardia💓 = HR >100, physiologic or pathologic

💘Tachyarrhythmia💘 = Heart rhythm disorder causing *pathologic* tachycardia

If sinus rhythm:
➡️P before each QRS wave
➡️QRS following each P
➡️P wave upright in lead II
Then ⏩ Sinus Tachycardia ImageImageImage
🧠Let's develop a diagnostic framework for tachyarrhythmias

QRS complex on EKG is 💯

🔹Narrow complex (QRS <120ms): SVT

🔷Wide complex (QRS >120ms): SVT w/ aberrancy or ventricular tachycardia (V. tach)

Check out this ⤵️schema from @CPSolvers Image
SVT 🆚 V. tach

Quick tricks to identify V. tach on EKG:

✏️Concordance of precordial leads (all QRS complexes ➕ or all ➖)

✏️QRS complex ➖ in all inferior leads (II, III, aVF)

✏️AV dissociation w/ capture (QRS of normal duration) or fusion beats

Brugada Algorithm ⤵️ ImageImageImageImage
For *narrow* complex, next determine if irregular or regular

RTL schema by @haematognomist ⤵️

--
Ways to differentiate?

🪚Sawtooth pattern in inferior leads – A flutter

🌌Ectopic p wave – Atrial tachycardia

❎No p waves – A fib

🌈Irregularly regular, 3+ p waves – MAT ImageImageImageImage
Now, back to the earlier EKG...

Answer❓ Multifocal Atrial Tachy (MAT)!

♦️Unknown MoA, triggered activity from delayed afterdepolarizations

Etiologies:
🫁COPD exacerbation, pneumonia, pulmonary embolism
💘CHF exacerbation
💊theophylline

♦️No one predominant P wave morphology! Image
🪂Now, let's take a deeper dive into AVNRT🪂

🔷Most common SVT
🔷More common in younger women
🔷Spontaneous events or by ☕️🤸🍵
🔷AV node re-entry circuit

90% Typical:
-slow AV pathway for anterograde
-fast path. for retrograde

10% Atypical:
-fast anterograde
-slow retrograde ImageImageImage
For typical AVNRT:

Retrograde ⬅️ conduction typically occurs in the fast 🚀 pathway

Atria are activated either simultaneously with or just after the ventricles so P wave is in the ST segment or *buried* within the QRS complex

🔥So on EKG, the RP interval < PR interval🔥 ImageImage
We've covered a lot! Hopefully you're not😴

Let's hit it home with the treatment of SVT 🎯

Acute: Vagal stimulation (carotid sinus massage, Valsalva maneuver) or adenosine

💊Beta-blockers or calcium channel blockers can also suppress AVNRT event by blocking/slowing the AV node Image
⁉️ Modified Valsalva ⁉️

The REVERT study from 🇬🇧 randomized patients presenting w/ SVT to either modified or standard Valsalva

Conclusion:
-Modified Valsalva should be considered as first-line treatment!

Video of Modified Valsalva: bit.ly/3hJuaVN ImageImage
Radiofrequency catheter ablation 🔪 is first-line therapy for symptomatic chronic AVNRT (palpitations, SOB, neck pulsations)

📢 Large registry studies report >95% success rates of slow-pathway ablation (preferred 🎯), with a <1% risk of AV block

🧊Cryoablation is alternative🧊 Image
💥Summary/pearls for Tachyarrhythmias💥

1. Assess hemodynamic instability
2. EKG is 🗝️ - wide or narrow QRS
3. If narrow, determine if regular or irregular rhythm

Other labs/imaging: BMP, TSH, Troponin, BNP, urine toxicology, Echo

RTL Episode Handout: bit.ly/35cEAbw Image
REFs (1/3):
[1,8]
[3]uptodate.com/contents/overv…
[4,7,10] Mikhail Torosoff & Steven A. Fein. "I Read ECGs An interactive practical guide to the electrocardiogram interpretation".
[5]clinicalproblemsolving.com/dx-schema-supr…
[6]litfl.com/vt-versus-svt-…
REFs (2/3):
[6]Dale Dubin "Rapid Interpretation of EKGs". 6th edition.
[7] litfl.com/atrial-tachyca…
[9]osmosis.org/learn/AV_reent…
[9]litfl.com/supraventricul…
[9]aafp.org/afp/2010/1015/…
REFs (3/3):
[9] Baltazar RF. Supraventricular Tachycardia due to Reentry. In: Basic and Bedside Electrocardiography. 1st ed.; 2009. doctorlib.info/cardiology/ele….
[10]ucsfmed.wordpress.com/2017/07/18/mof…
[11,13]ahajournals.org/doi/full/10.11…
[12]thelancet.com/journals/lance…

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9 Feb
#Rheumatology Fun

Let’s take a deep dive into a unique subset of rheumatic diseases 👇

This week's RTL guest tweetorial from @MithuRheum! Image
CASE 1:

🔹A 52 yo male presents to clinic w/ 6 months of hand ulcerations on the dorsal surface of the hands & elbow, oral ulcers, a violaceous periorbital rash and mild arthralgias

🔸CT chest demonstrates nodular opacities Image
Based on the clinical presentation and photograph of the ulcers, which of the following is the most likely diagnosis?

🤔
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⁉️Did you know the left atrial appendage can be described as chicken wing🍗, cactus 🌵, windsock, & cauliflower morphology⁉️

Full 🧵on 💘Atrial Fibrillation💘

🎧RTL Ep. 23: bit.ly/3b6svs0

Thanks to @Gurleen_Kaur96 for this week's tweetorial!

🥇First, let's review the basics of atrial fibrillation (A.fib)

✨Most common cardiac arrhythmia✨

Etiology:
-🎆Rapid firing from foci in pulmonary vein triggers reentrant waves🎆

EKG:
-RR intervals have no pattern ➡️ irregularly irregular
-No distinct P waves
An aside on terminology 📅:

🔹Paroxysmal: self-terminated in < 7 days

🔹Persistent: > 7 days or need cardioversion

🔹Long-standing persistent: > 1 year

🔹Permanent: no attempt to restore/maintain sinus rhythm

🔹A.fib with rapid ventricular response (RVR): >110-120 bpm
Read 24 tweets
29 Dec 20
Based on Run The List 📝 Episode 48, here goes nothing with a #tweetorial on lymphadenopathy (LAD)

Thanks to Kushal (@k_vaishnani) for this week's RTL edition! Image
What’s 🔑 in narrowing down the etiology of lymphadenopathy?

🔸LOCATION of LAD (axillary, supraclavicular, inguinal)

🔸Detailed HISTORY (including exposures, travel, constitutional symptoms)

Below is a helpful list of exposures & associated LAD 👇 Image
Physical characteristics of LAD also provide hints:

🔹SIZE - greater than size of last phalanx of pinkie is a good rule of 👍; clinically significant!

🔹TENDERNESS - due to inflammatory process, suppuration (pus formation), or hemorrhage into necrotic center of a malignant node
Read 25 tweets
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Let's HIT the topic 💊 Heparin-induced Thrombocytopenia (HIT)🩸!

This #tweetorial is a deep dive into Episode 43 of Run the List (RTL) on Thrombocytopenia: bit.ly/32feVfQ

Thanks @LeelaChock for covering this week’s topic!
Thrombocytopenia is a broad topic!

In Ep. 43 of RTL, Dr. Robert Stern, @NavinKumarMD, & @sonorato11 go over a general approach to thrombocytopenia 👇

Broadly, there are THREE umbrellas:

1. ⬆️ destruction

2. Splenic sequestration 💪

3. ⬇️ production

runthelistpodcast.com/s/RTL_Thromboc…
HIT (Heparin-induced thrombocytopenia), is classified under “⬆️ destruction”

HIT in-depth:

✨It is *common*, occurring in 1 out of 5,000 hospitalized patients✨

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Read 18 tweets
29 Oct 20
Factor V Leiden 🦁 & Protein C/S deficiency 🐯 & VTE 🐻, oh my!

In this #tweetorial, we're going to tackle Thrombophilia & Anticoagulation

Thanks @_blake_smith for this week's edition
ICYMI

🎶catch Episode 47: Thrombophilia & Anticoagulation here: apple.co/2XhpRIU

In it, hematology expert Dr. Jean Connors @connors_md begins with a review of hemostasis🩸(coagulation)
1⃣PRIMARY hemostasis:

initial vessel damage ➡️

exposure of sub-endothelial collagen ➡️

von Willebrand Factor (vWF) from ECs binds collagen ➡️

exposed vWF binds to GpIb receptor on platelets (plts) ➡️

plt adhesion! 💥
Read 20 tweets
15 Jun 20
Who's ready for another #tweetorial?!

This week on HYPOCALCEMIA 🥺🥛

ICYMI, listen to our "Episode 35: Hypocalcemia" pod: apple.co/2XhpRIU
In the episode, Dr. OP Hamnvik @ohamnvik drops an early pearl & teaches us that the clinical manifestations of hypocalcemia occur depending on:

1) TEMPO

2) DEGREE of hypocalcemia

How quickly did the Ca drop & by how much?

If there's been a gradual⬇️ -> pt can be asymptomatic
Remember from last week, that Ca is tightly regulated in the blood (nl = 8.6-10.2 mg/dL). HypoCa = <8.6 mg/dL; tempo & level matter!

Calcium can be found in:

BONES (99% of body's Ca, stored as hydroxyapatite)

PROTEIN (bound to albumin)

FREE (ionized, regulates PTH level)

[1]
Read 23 tweets

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