1. If you thought yesterday's more than 4,400 deaths will be the worst of the American pandemic, or the previous >300,000 cases in a day, you're not paying attention.
We're already approaching 1% B.1.1.7 strain
2. This strain's destiny is to become dominant here in the weeks ahead. That mean's going vertical. Look at Ireland with >40% B.1.1.7
3. We're not doing the vital things we need to do to go to full prevent mode
4. Regarding the last point, there are preliminary signs from Israel that their aggressive vaccination strategy is having a favorable impact on hospitalizations, via @asafpeer @jacksonlab
5. We were able to get to 1.2 million vaccinations in 1 day here (@BNODesk). That needs to be 2.5 or more million every day, 7 days a week
6. If there ever were a time for the United States to pull out all the stops, this is it.

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More from @EricTopol

8 Jan
Why it is time (never too late) to get super-serious
1. Holiday surge after holiday surge is small potatoes compared with a superspreader strain.
B.1.1.7 is here, <1%, but will be dominant in the weeks ahead
It is a strain, by definition:
2. The "superspreader" strains B.1.1.7 and 501Y.V2
Because they are more infectious (X%, but much more than D614G ,which had only a modest transmission ⬆️)
More people will get sick
More people will get hospitalized
More people will get #LongCovid
More people will die
3. Over the next several weeks, these new strains will become the dominant ones in the United States, just as they have in the UK and other countries. Exponential spread. Why we need to contain the virus and vaccinate 24/7 like there's no tomorrow.
Read 6 tweets
6 Jan
If you want to know about #SARSCoV2 as it started and where it is going, you talk to @edwardcholmes, a leading evolutionary virologist @Sydney_Uni
medscape.com/viewarticle/94… @Medscape video and transcript
a 🧵 /1
Eddie's Jan 10th tweet that will go down in history since the virus sequence led to the design of mRNA vaccines 2 days later /2
Prof Holmes has been studying viruses for 30 years, in recent years a lot of metagenomic sequencing, the technique used to identify #SARSCoV2, and a major collaboration with Prof Zhang in Shanghai
time.com/collection/100… /3
Read 14 tweets
3 Jan
Connecting the dots between RSV, F, erection, S, and 2P's
1. The @McLellan_Lab work on RSV virus to stabilize the F protein (which may lead to successful vaccines)
From newyorker.com/magazine/2021/… @NewYorker by @lawrence_wright
2. The @ScienceMagazine paper in 2013 that was, in retrospect, a frontrunner for coronaviruses and #SARSCoV2 sharing the property of membrane fusion and the need to stabilized the fusion protein to get effective vaccines
3. That was by X-ray crystallography which didn't enable visualization of the spike (S) protein of coronaviruses until this @nature publication by @WardLab1 @McLellan_Lab @KizzyPhD and colleagues in 2016 via cryo-EM nature.com/articles/natur…
Read 6 tweets
1 Jan
On our new podcast, we interviewed @angie_rasmussen, one of the leading virologists, who has been a guiding light during the pandemic. Thread here to summarize, transcript and audio medscape.com/viewarticle/94… @cuttingforstone /1
Current status
"We're essentially experiencing the equivalent of a 9/11 every day in terms of number of deaths; our hospital systems are overburdened. ...We're going to be dealing w/ this for some time to come, even after people get the vaccine, certainly #LongCovid is real." /2
On her strong efforts for dispelling misinformation
"My philosophy about public health is that you can't have it without the engagement of the public. And my philosophy about communication is that information empowers people to decide for themselves" /3
Read 12 tweets
30 Dec 20
The Phase 3 @moderna_tx #SARSCoV2 vaccine trial is published @NEJM nejm.org/doi/full/10.10…
The historic cumulative event curve
Subgroup analysis, maintenance of efficacy across the board
Read 6 tweets
28 Dec 20
We interviewed @SteveFDA and Peter Marks @US_FDA about the new vaccines
webmd.com/coronavirus-in… w/ @drjohnwhyte @WebMD @Medscape
Key points that we covered:
1. The EUA tightening that got the trials to full efficacy completion and better read on safety
2. Operation/Project Warp Speed was invented by Peter Marks (a star trekkie) to streamline and accelerate the path to a successful vaccine
More on that here washingtonpost.com/health/coronav… by @lauriemcginley2
3. Why didn't the vaccine trials study transmission (mucosal impact/ sterilization immunity)?
The requirement of the participants for daily nasopharyngeal swabs would have been cumbersome and slowed down the trial's critical question of preventing illness
Read 9 tweets

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