On our new podcast, we interviewed @angie_rasmussen, one of the leading virologists, who has been a guiding light during the pandemic. Thread here to summarize, transcript and audio medscape.com/viewarticle/94… @cuttingforstone /1
Current status
"We're essentially experiencing the equivalent of a 9/11 every day in terms of number of deaths; our hospital systems are overburdened. ...We're going to be dealing w/ this for some time to come, even after people get the vaccine, certainly #LongCovid is real." /2
On her strong efforts for dispelling misinformation
"My philosophy about public health is that you can't have it without the engagement of the public. And my philosophy about communication is that information empowers people to decide for themselves" /3
The diagnosis of #SARSCoV2 reinfection is very challenging and Dr. Rasmussen provides the best and complete explanation for why that's the case. One dimension of that is being able to culture the virus in a BSL (biosafety level)-3 lab /4
Many are not familiar with what BSL-3 and 4 labs are all about. Great summary here from her extensive experience. More in podcast/transcript on her response in BSL-4./5
What about #LongCovid?
Angie reviewed parallels w/ ME/CFS
Because this is the 1st time we've had a pandemic w/ such broad effects on different organ systems ...try to understand how an acute viral infection can cause these complex, syndromic, long-term diseases like ME/CFS." /6
What about getting #SARSCoV2 from surfaces?
It's complicated. A master class here, starting with this, and will let you read on or listen to get the whole response, which gets into aerosols, too /7
Practical take away
"We needn't be bleaching everything in sight and disinfecting our produce, our groceries, and our mail and so forth. But we should still do good hand hygiene; we should still emphasize that we should disinfect common high-touch surfaces, such as doorknobs.../8
She's had so much experience w/ PAPR (picture) real deal fitted N95s working in BSL-3/4.
Translate:
"My feeling is that if risk reduction is additive, if all of these measures — masks, social distancing, and ventilation — add up and create the most exposure reduction possible"/9
PCR tests don't give back Cycle threshold (Ct) values. Should they? A great explanation of the intricacies and potential usefulness, just a bit of it here. And comments on rapid home tests /10
We were lucky about rapidly developing successful #SARScoV2 vaccines but that was an outgrowth of considerable experience w/ other viruses, including MERS and Ebola. Watch out for Nipah (movie Contagion). How to get ready for the next pandemic /11
Dr. Rasmussen will soon be moving to @VIDOInterVac in Canada. She is a remarkable resource, not just because of her knowledge base, but exquisite ability to communicate for all. A real gem. We've been so fortunate to learn from her and look forward to much more in the future /f

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More from @EricTopol

3 Jan
Connecting the dots between RSV, F, erection, S, and 2P's
1. The @McLellan_Lab work on RSV virus to stabilize the F protein (which may lead to successful vaccines)
From newyorker.com/magazine/2021/… @NewYorker by @lawrence_wright Image
2. The @ScienceMagazine paper in 2013 that was, in retrospect, a frontrunner for coronaviruses and #SARSCoV2 sharing the property of membrane fusion and the need to stabilized the fusion protein to get effective vaccines
science.sciencemag.org/content/sci/34… ImageImage
3. That was by X-ray crystallography which didn't enable visualization of the spike (S) protein of coronaviruses until this @nature publication by @WardLab1 @McLellan_Lab @KizzyPhD and colleagues in 2016 via cryo-EM nature.com/articles/natur… Image
Read 5 tweets
30 Dec 20
The Phase 3 @moderna_tx #SARSCoV2 vaccine trial is published @NEJM nejm.org/doi/full/10.10…
The historic cumulative event curve
Subgroup analysis, maintenance of efficacy across the board
Read 6 tweets
28 Dec 20
We interviewed @SteveFDA and Peter Marks @US_FDA about the new vaccines
webmd.com/coronavirus-in… w/ @drjohnwhyte @WebMD @Medscape
Key points that we covered:
1. The EUA tightening that got the trials to full efficacy completion and better read on safety
2. Operation/Project Warp Speed was invented by Peter Marks (a star trekkie) to streamline and accelerate the path to a successful vaccine
More on that here washingtonpost.com/health/coronav… by @lauriemcginley2
3. Why didn't the vaccine trials study transmission (mucosal impact/ sterilization immunity)?
The requirement of the participants for daily nasopharyngeal swabs would have been cumbersome and slowed down the trial's critical question of preventing illness
Read 9 tweets
26 Dec 20
Countries the B.1.1.7 variant has been found in:
UK, Denmark, Singapore, Australia, Netherlands, Sweden, Spain, Switzerland, Lebanon, France, Israel, Italy.
Hard to imagine it has not reached US by this time
Add: Japan, Iceland, Belgium, Germany
Now add Ontario, Canada in a couple with no history of travel
Read 4 tweets
24 Dec 20
We've now doubled the peak hospitalizations from the previous 2 US case surges.
And it's no wonder the death toll again today is nearly 3,500.
@COVID19Tracking
Sure the virus is hard to contain, but that's especially the case when so little is being done
The @HHSgov declared covid as a public health emergency on Jan 31st
And @WhiteHouse a national emergency March 13th whitehouse.gov/presidential-a…
If that was emergency, then what is this?
The actions we could take beyond financial support that still has not been approved......
1. Distribute high quality (surgical or K/N95) masks to all households [@USPS planned 650 million distribution in April, blocked by @WhiteHouse]
2. Make mask mandates a national policy with enforcement
3. Provide free rapid home covid tests to all households for daily use
Read 5 tweets
23 Dec 20
1. Structural biology has been a standout in the pandemic, mapping the virus, antibodies and vaccines atom by atom. So I had a conversation with one of its leaders, Andrew Ward @WardLab1, my @scrippsresearch colleague soundcloud.com/prescrippsions…
2. Back in 2016, Andrew and his colleagues were the first to see and publish the coronavirus spike protein, via cryo-electron microscopy (a common cold virus, HKU1) nature.com/articles/natur… @nature
Note the team, which proved to be formidable
@McLellan_Lab @KizzyPhD Barney Graham
3. In the podcast, Andrew reviews how they came together. A next act was the famous 2P (2 proline substitutions) paper that was rejected 5 times before being published @PNASNews
Subthread about that here:
Read 14 tweets

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