Still confused about the 2nd dose vaccine supply? Me too, but I think this is what happened: 🧵

Let’s go chronologically. Last Thursday, governors wrote a letter to @SecAzar requesting second doses not be held in reserve and instead immediately be made available:
2. Friday, CNN reported the Biden team planned to do just that:
3. Tuesday @SecAzar said OWS would make the change as well.

Azar: "We can now ship all of the doses, that had been held in physical reserve with second doses being supplied by doses coming off of manufacturing lines with quality control going forward."

4. @SecAzar also noted in that announcement:

"Each week, doses available would be released to first cover the needed second doses, and then cover additional first vaccinations." (4)
5. There was an expectation that with release of 2nd doses would come an immediate increase in # of doses states could order.

That... didn't happen: washingtonpost.com/health/2021/01…
6. Governors, especially those who wrote original letter to @SecAzar, were angry.

MN's @GovTimWalz at a press conference yesterday: "They were lying. They don't have any doses held back. There is no strategic supply for the 2nd dose."

@OregonGovBrown:
7. This sounds devastating. But wait... Pfizer says it still has ALL its second doses of previous shipments to the US? So... there is a reserve?
8. @SecAzar was asked by @LesterHoltNBC last night about a reserve.

Azar: "No, there's not a reserve stockpile. We did that in December to be extra cautious." Bc of more confidence in manufacturing, "we've made that available for states to order."
9. The wording around a reserve is confusing. Clearly, from Pfizer's statement, the 2nd doses to pair with the 1st exist. They will be used as 2nd doses, as we're now 1 month+ from 1st vaccines given, so many are now getting their 2nd shots.
10. Further, NYT reports it's all a big misunderstanding: nytimes.com/live/2021/01/1…
11. The change is that Operation Warp Speed is no longer putting half of newly made vaccines into reserve as 2nd doses.

Ok. But. It still doesn't 100% add up.

Let's think about this in simple numbers bc it all makes my brain hurt:
12. Let's say week 1, 5M doses were available from Pfizer. 2.5M shipped as 1st dose, 2.5M stored as second.

The data show, though, only 1/3 were administered. So, 330K used, 670K stored (by states).

Stored doses now = 3.17M. Way more than were given as first shots.
13. Next week, same thing happens. 5M made. 2.5M shipped, 2.5M stored.

But again only 1/3 administered, so another 670K stored by states. Stored doses in week 2 now (states & federal) = 6.34M. [Remember these are hypothetical numbers, me trying to puzzle out what's happening.]
14. HHS says states are only ordering 75% of what they could. We know CDC & state vaccination numbers have a lag, and more is getting used, but there seems to still be excess vaccine out there.

Did I say at the beginning of this thread I was going to clear this up? 🤷‍♀️
15. Finally, one thing @PresElectBiden pledged in his vaccine speech yesterday was transparency. Hope that is true bc it would help a lot (clearly).

Now, everyone tell me how I got this wrong (srsly) - what did I miss?

cc @walidgellad @CT_Bergstrom @jasonlschwartz
16. Actually one more thing, which was the impetus for me waking up on a Saturday AM & feeling like I HAD to write a 16-tweet thread:

This miscommunication had real implications for people trying to get vaccines. Oregon now says seniors will have to wait 2 more weeks:
17. We can argue over whose fault this miscommunication was (and that’s already happening between federal govt and states), but the bottom line is - this really sucks for people who desperately want vaccines.

We need much, much more clear communication on supply.
18. I did this before coffee and now realize my hypothetical math was all over the place (ie when I calculated 1/3 of hypothetical doses administered I did it out of 1M rather than 2.5M). So the hypothetical numbers are off, but they’re hypothetical so. Anyway more ☕️

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More from @megtirrell

7 Jan
.@NYGovCuomo : "If the UK spread catches on in NY, hospitalization rate goes up, hospital staff gets sick - then we have a real problem. Then we're at shutdown again."

The problem with capacity now is staff shortage, he says. "We have beds, we have equipment." Primarily nurses.
Cuomo: Very worried about UK strain. Still just 1 case confirmed in NY, but believe we have more. Notes spread in UK only took about 3 weeks.

Says this concern + staff shortages at hospitals is why such a push for faster vaccination of health-care workers.
Cuomo: "We have seen a dramatic increase" in performance of vaccinations.

Were doing 10k per day for first several wks

On Monday, went to 30k

Tuesday, a little over 30k

Wednesday, went to 50k

And today going to be in excess of 50k

"That's 5 times the rate they were doing."
Read 11 tweets
6 Jan
J&J’s CEO, Alex Gorsky, on events in Washington: Image
.@steveubl of @PhRMA on events in Washington: Image
Pfizer CEO @AlbertBourla letter to employees on events in Washington: Image
Read 4 tweets
6 Jan
"Certainly it's had a rocky beginning," @NIHDirector tells @washingtonpost Live of #covid19 vaccine rollout. "Maybe we shouldn't be too shocked that it didn't go like clockwork," but says "things are starting to pick up." Says 1M injections per day "is good benchmark to reach."
Collins declines to make a specific estimate for herd immunity, but says "let's go for 80-85%; that ought to be sufficient for achieving herd immunity."

"Talking in the neighborhood of 300M... getting immunized in the coming months."

(How do we do that w/o vaccinating kids?)
"There's a pretty clear path for getting where we need to be by summer," @NIHDirector tells #postlive of #covid19 vaccine rollout. Says processes are falling into place.
Read 5 tweets
20 Dec 20
CDC’s #ACIP just now reiterates OWS projections for #covid19 vaccine supply:

By end of Dec: enough for 20M people
End of Jan: enough for 30M more people
End of Feb: enough for 50M more people

(2 doses each)

We know Dec supply will stretch into 1st wk of Jan for administration
CDC’s #ACIP has not yet voted, but recs for groups next in line for #covid19 vaccines are people 75+ and frontline essential workers, including:
Firefighters, police
Teachers, support staff, daycare
Food & agriculture
Manufacturing
Corrections
Postal, public transit
Grocery store Image
CDC #ACIP’s considerations for next groups + how many in each for #covid19 vaccine prioritization (vote this afternoon):
Phase1a: healthcare workers, nursing home residents (24M)
1b: Frontline essential workers, 75+ (49M)
1c: 65-74, high-risk, other essential workers (129M) Image
Read 6 tweets
7 Dec 20
.@NYGovCuomo asks Dr Fauci: When is 75-80% of population being vaccinated feasible?

Dr Fauci: Going to be entirely dependent on how well we do - how I do, you do - on getting message out about how important it is for people to get vaccinated. (1)
Dr Fauci to Cuomo on #covid19 vaccination timeline:

-By end of Dec, substantial proportion of health-care providers and people in nursing homes will be vaccinated

-By the time you get to beginning of April, you'll start to get people who have no high priority (2)
Dr Fauci: "In a full-court press," through April, May and June, by the time you get to the summer (w prime-boost doses & 7-10 days for immunity), by the "core of summer, end of summer, start of third quarter of 2021, we should be in good shape. That's what I'm hoping for." (3)
Read 4 tweets
3 Dec 20
This appears to be an explainer of a change that happened in Pfizer's #covid19 vaccine supply expectations between Sept. 9 and Nov. 9, which flew under the radar because Pfizer reduced the 2020 supply expectation in the same release it reported 90% efficacy for the vaccine (1)
In Aug & Sept, Pfizer was forecasting up to 100m doses of its #covid19 vaccine by the end of 2020, and up to 1.3B doses by the end of 2021: (2) Image
Nov 9, when Pfizer reported its first phase 3 efficacy data, it included the new (reduced) forecast for supply: (Link here bc the dateline isn’t visible in this photo: pfizer.com/news/press-rel…) (3) Image
Read 6 tweets

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