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Meg Tirrell Profile picture
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20 Dec, 6 tweets, 5 min read
CDC’s #ACIP just now reiterates OWS projections for #covid19 vaccine supply:

By end of Dec: enough for 20M people
End of Jan: enough for 30M more people
End of Feb: enough for 50M more people

(2 doses each)

We know Dec supply will stretch into 1st wk of Jan for administration
CDC’s #ACIP has not yet voted, but recs for groups next in line for #covid19 vaccines are people 75+ and frontline essential workers, including:
Firefighters, police
Teachers, support staff, daycare
Food & agriculture
Manufacturing
Corrections
Postal, public transit
Grocery store Image
CDC #ACIP’s considerations for next groups + how many in each for #covid19 vaccine prioritization (vote this afternoon):
Phase1a: healthcare workers, nursing home residents (24M)
1b: Frontline essential workers, 75+ (49M)
1c: 65-74, high-risk, other essential workers (129M) Image
More context on how CDC #ACIP is making recommendations on #covid19 vaccine prioritization: balancing goals of preventing morbidity & mortality (nursing home residents, 75+, 65-74, high-risk), and preserving functioning of society (health care workers, essential workers) Image
CDC #ACIP votes 13-1 in favor of recommendation to prioritize groups for #covid19 vaccine:
1b: 75+, frontline essential workers
1c: 65-74, high-risk, other essential workers Image
CDC #ACIP on what conditions may characterize someone as high risk (not exhaustive list; may include others):
Obesity
Type 2 diabetes
COPD
Heart condition
Chronic kidney disease
Cancer
Immunocompromised from organ transplant
Sickle cell
Pregnancy
Smoker (current/past) Image

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More from @megtirrell

Meg Tirrell Profile picture
7 Dec
.@NYGovCuomo asks Dr Fauci: When is 75-80% of population being vaccinated feasible?

Dr Fauci: Going to be entirely dependent on how well we do - how I do, you do - on getting message out about how important it is for people to get vaccinated. (1)
Dr Fauci to Cuomo on #covid19 vaccination timeline:

-By end of Dec, substantial proportion of health-care providers and people in nursing homes will be vaccinated

-By the time you get to beginning of April, you'll start to get people who have no high priority (2)
Dr Fauci: "In a full-court press," through April, May and June, by the time you get to the summer (w prime-boost doses & 7-10 days for immunity), by the "core of summer, end of summer, start of third quarter of 2021, we should be in good shape. That's what I'm hoping for." (3)
Read 4 tweets
Meg Tirrell Profile picture
3 Dec
This appears to be an explainer of a change that happened in Pfizer's #covid19 vaccine supply expectations between Sept. 9 and Nov. 9, which flew under the radar because Pfizer reduced the 2020 supply expectation in the same release it reported 90% efficacy for the vaccine (1)
In Aug & Sept, Pfizer was forecasting up to 100m doses of its #covid19 vaccine by the end of 2020, and up to 1.3B doses by the end of 2021: (2) Image
Nov 9, when Pfizer reported its first phase 3 efficacy data, it included the new (reduced) forecast for supply: (Link here bc the dateline isn’t visible in this photo: pfizer.com/news/press-rel…) (3) Image
Read 6 tweets
Meg Tirrell Profile picture
5 Oct
.@HallieJackson says Regeneron Chief Scientific Officer Dr George Yancopoulos coming up next with her on @MSNBC
@HallieJackson asks: What do you know about these 3 drugs together?

GDY: Our antibody cocktail essentially just mimics the normal immune system... theoretically there should not be any additional interactions with these other medications than you'd have with your own antibodies.
Yancopoulos also notes that bc Regeneron's antibody cocktail boosts the immune response, the concern about giving immunosuppressive dexamethasone earlier in course of disease may be lessened.
Read 4 tweets
Meg Tirrell Profile picture
8 Sep
AstraZeneca full statement here on clinical trial hold for its #COVID19 vaccine, scooped by ⁦@statnews⁩ statnews.com/2020/09/08/ast…
A few takeaways: it’s not clear what the issue is, if it will have a meaningful impact on AstraZeneca’s trial, or the trials of other #Covid19 vaccine makers.

(Though stocks are reacting at least in short term as if this is a boon for Moderna, Novavax etc)
Better takeaway here from @natashaloder, especially in this time of fear of a rushed vaccine:
Read 4 tweets
Meg Tirrell Profile picture
15 Jul
Dr Fauci, at an Atlantic event, was just asked about the criticisms coming at him from the Trump Administration:

Fauci: "It is a bit bizarre, I don't really fully understand it." (More)
Fauci on the list from Trump Administration circulated alleging what he got wrong on #COVID19: "If you sit down and talk to the people involved in that, they are taken aback by what a big mistake that was." (2)
Fauci: "If you talk to reasonable people from the White House, they realize it was a major mistake on their part bc it doesn't do anything but reflect poorly on them. I can't figure out in my wildest dreams why they would want to do that." (3)
Read 4 tweets
Meg Tirrell Profile picture
18 May
Moderna says it plans to start phase 3 #COVID19 vaccine trial in thousands of people in July, with phase 2 of 600 people expected to start soon (1)
Moderna’s plan to expedite clinical development of #COVID19 vaccine: start phase 2 with safety data from phase 1; phase 3 with safety of phase 2 + efficacy data from phase 1 to guide dose selection (2)
Moderna’s phase 2 #COVID19 vaccine trial will enroll 600 people and test doses of 50 and 100 micrograms; the planned high dose was revised (from 250 micrograms) based on phase 1 results (3)
Read 6 tweets

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