As horrific as #COVID19 looks right now, it is almost certainly about to get worse—
“I’m very very concerned that we’ve now gone from a virus that we could control to a virus that we really can’t, unless we do something very dramatic,” said @K_G_Andersen. statnews.com/2021/01/14/mor…
2) “They’ve raced through South Africa, the United Kingdom, and, increasingly, elsewhere, and now, new, more infectious variants of the coronavirus have gained toeholds in the United States.
3) “If they take off here — which, with their transmission advantages, they will, unless Americans rapidly put a brake on their spread — it will detonate something of a bomb in the already deep, deep hole the country must dig out of to end the crisis.
4) “In other countries, scientists fear the variants will reignite outbreaks in places where the virus has already been tamped down. But in the U.S. the variants could accelerate what’s already exponential spread in certain areas, and make reining in epidemic all more difficult.
5) Here is my earlier thread on the Brazil 🇧🇷 discovered variant, now called P1 variant. It has the worrisome E484k mutation.
BREAKING UPDATE—Trump travel rules to be reversed by Biden!! Spokesperson @jrpsaki says Biden “does not intend to lift these restrictions on 1/26. In fact, we plan to strengthen public health measures around international travel in order to further mitigate spread of #COVID19.”
2) Earlier, Trump issued a proclamation lifting COVID-19 travel restrictions barring entry to the US of foreign nationals from the UK, Ireland, much of Europe, and Brazil effective January 26 at 12:01 am.
3) Trump, who once bragged about his “great” travel bans to stop #COVID19, now lifts his restrictions on foreign nationals from UK 🇬🇧 Ireland 🇮🇪, much of EU, and Brazil (origins of all the #B117 and #P1 variants, where they are rampant). No lifting on China🇨🇳 travel restrictions.
WORRISOME ON *E484* MUTATION—New study from blood of 44 people infected in 1st wave in S Africa🇿🇦 was tested against new #SARSCoV2 variant #B1135 (501Y.V2)—found antibodies from **21 of 44 did not recognize** the new B1125 variant—Almost half! #COVID19 🧵
2) This new E484K study is by @nicd_sa - respected research group. That said, antibody immunity is not all of immunity. T cells also offer spike protein recognizing immunity too (not measured).
Meanwhile—other studies on E484K immune escape—it’s in both 🇿🇦 & Brazil 🇧🇷 variants.
3) Why are we so worried about E484K? In another recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies in 9 of 11 patients, some with 10x reductions in neutralizing ability!
BREAKING—new #B117 variant & vaccine data from 🇬🇧 research lab shows mutations in B117’s spike protein yields a ~3.8x reduction in efficacy of vaccine-generated neutralization antibodies compared to wildtype (WT) #SARSCoV2 strain. 10 of 15 people had >3x lower neutralization. 🧵
2) Notably, @GuptaR_lab studied 15 people who had Pfizer mRNA vaccine against pseudo virus bearing Spike protein w/ mutations in B117 variant (del69/70, del 144/145, N501Y, A570D, P681H, T716I, S982A, D1118H). They found a modest reduction in efficacy.
3) paper pending—among 15 individuals with neutralisation activity 3 weeks after the Pfizer mRNA vaccine (immunity has already kicked in), 10 showed >3-fold reduction in efficacy of antibodies against B.1.1.7 mutant.
➡️The highest was *6x* reduction in neutralization. #COVID19
LET THIS SINK IN: So many people have died in Los Angeles that officials have suspended air-quality rules that limit cremations because current 2x deaths is “leading to hospitals, funeral homes & crematoriums exceeding capacity” unable to clear backlog of dead bodies. #COVID19
2) And the LA County order says there's another surge of deaths that's approaching, fueled by the gatherings that took place over the New Year's holiday.
The emergency order will be in effect for 10 days and can be extended, the agency said.
3) Same time, LA County has historically had bad air pollution which damages the lungs. But lung is also one thing COVID damages the most... thread 🧵 below...
LONG COVID—30% of hospital recovered #COVID19 patients end up back in hospital in <5 months; up to 12% die of complications. “we really need to prepare for #LongCovid. It’s a mammoth task to follow up w/ these patients, but monitoring needs to be arranged” telegraph.co.uk/news/2021/01/1…
2) “Researchers at the UK’s Leicester University and the Office for National Statistics found that out of 47,780 people discharged from the hospital, 29.4 percent were readmitted within 140 days, the Telegraph reported.
Of the total, 12.3 percent succumbed to the illness.
3) “Many people who suffer long-lasting effects of the coronavirus develop heart problems, diabetes and chronic liver and kidney conditions.
BREAKING—At 10:20am, Capitol Hill staffers received message:
“All buildings within the Capitol Complex: External security threat, no entry or exit is permitted, stay away from exterior windows, doors. If outside, seem cover. USCP”
➡️ Inauguration rehearsal also evacuated.
2) There is a fire, unclear if accident or something worse.