5) I’m sometimes too sad to think about the alternate universe... in which we listened to science. So many #COVID19 deaths, hospitalizations, and #LongCovid could’ve been prevented.
6) Some people ask why did I put my science career on the line by shouting at the rooftops. Well, I consider my living on borrowed time. We all die someday—I am merely living because I survived a baseball sized tumor when I was young that took out my lung and other organs parts.
7) so as William Wallace says in Braveheart... “every man dies, but not every man really lives”. And because I got a second free chance at life, I wanted to help the world... so I became an epidemiologist... short story below 👇
BREAKING—Federal appeals court strikes down Trump EPA’s industry-friendly rule for power plants violates federal law, in a searing defeat for the Trump’s deregulatory agenda! Biden WH will have a clean slate for regulating power plant emissions. HUGE! news.bloomberglaw.com/environment-an…
2) The U.S. Court of Appeals for the District of Columbia Circuit vacated the Affordable Clean Energy rule and remanded it to the Environmental Protection Agency, giving the incoming
3) The decision undercuts Trump officials’ bid to leave a legacy of deregulation, tossing one of the administration’s highest-profile replacements of aggressive Obama-era environmental rules.
VENTILATION IS CRITICAL—“Being in a well ventilated space can reduce the risk of inhaling tiny airborne pathogens by 70%”, says @CathNoakes
My take—school cafeterias **must** be fully open-air ventilated or in outdoor tents until #COVID19 pandemic over. bbc.co.uk/sounds/play/m0…
2) Key is ventilation. Japan assumed it was airborne from the very beginning. Hence their mask culture and focus on air flow. Here is how to ventilate your school classrooms if unable to open the window. #COVID19
3) We often say in environmental health, "the solution to pollution is dilution". ventilation is the key air dilution and air replacement method.
BREAKING UPDATE—Trump travel rules to be reversed by Biden!! Spokesperson @jrpsaki says Biden “does not intend to lift these restrictions on 1/26. In fact, we plan to strengthen public health measures around international travel in order to further mitigate spread of #COVID19.”
2) Earlier, Trump issued a proclamation lifting COVID-19 travel restrictions barring entry to the US of foreign nationals from the UK, Ireland, much of Europe, and Brazil effective January 26 at 12:01 am.
3) Trump, who once bragged about his “great” travel bans to stop #COVID19, now lifts his restrictions on foreign nationals from UK 🇬🇧 Ireland 🇮🇪, much of EU, and Brazil (origins of all the #B117 and #P1 variants, where they are rampant). No lifting on China🇨🇳 travel restrictions.
WORRISOME ON *E484* MUTATION—New study from blood of 44 people infected in 1st wave in S Africa🇿🇦 was tested against new #SARSCoV2 variant #B1135 (501Y.V2)—found antibodies from **21 of 44 did not recognize** the new B1125 variant—Almost half! #COVID19 🧵
2) This new E484K study is by @nicd_sa - respected research group. That said, antibody immunity is not all of immunity. T cells also offer spike protein recognizing immunity too (not measured).
Meanwhile—other studies on E484K immune escape—it’s in both 🇿🇦 & Brazil 🇧🇷 variants.
3) Why are we so worried about E484K? In another recent study by @jbloom_lab, E484 mutation (inside the #SARSCoV2’s spike’s critical receptor binding domain) seemed to escape neutralizing antibodies in 9 of 11 patients, some with 10x reductions in neutralizing ability!
BREAKING—new #B117 variant & vaccine data from 🇬🇧 research lab shows mutations in B117’s spike protein yields a ~3.8x reduction in efficacy of vaccine-generated neutralization antibodies compared to wildtype (WT) #SARSCoV2 strain. 10 of 15 people had >3x lower neutralization. 🧵
2) Notably, @GuptaR_lab studied 15 people who had Pfizer mRNA vaccine against pseudo virus bearing Spike protein w/ mutations in B117 variant (del69/70, del 144/145, N501Y, A570D, P681H, T716I, S982A, D1118H). They found a modest reduction in efficacy.
3) paper pending—among 15 individuals with neutralisation activity 3 weeks after the Pfizer mRNA vaccine (immunity has already kicked in), 10 showed >3-fold reduction in efficacy of antibodies against B.1.1.7 mutant.
➡️The highest was *6x* reduction in neutralization. #COVID19